The imprint of viral oncoproteins on the variable clinical behavior among human papilloma virus-related oropharyngeal squamous cell carcinomas DOI Creative Commons
Malay K. Sannigrahi,

Lovely Raghav,

Ahmed Diab

et al.

Tumour Virus Research, Journal Year: 2024, Volume and Issue: 18, P. 200295 - 200295

Published: Nov. 1, 2024

Human papilloma virus-related (HPV+) oropharyngeal squamous cell carcinomas (OPSCCs) are variable in their progression, immune landscape, treatment responses, and clinical outcomes. Their behavior is impacted not only by differences host genomic alterations but also diversity levels activity of HPV-encoded oncoproteins. Striking HPV mRNA found among HPV+ OPSCCs likely derive part from variations the structurally diverse mix integrated episomal genomes they often contain. Viral oncoprotein function differential splicing two long polycistronic transcripts HPV16, type within most OPSCCs. Further variation viral arises distinct lineages sub-lineages which encode polymorphisms functionally important portions oncogenes. Here we review limited current knowledge linking expression to that influence OPSCC behavior. We summarize evolving understanding HPV16 physical genome state genetic variants potential contributions function. Addressing considerable remaining challenges defining quantitative qualitative imprint oncoproteins on each holds promise guide personalization therapy for this disease.

Language: Английский

How human papillomavirus (HPV) targets DNA repair pathways for viral replication: from guardian to accomplice DOI
Arushi Vats, Laimonis A. Laimins

Microbiology and Molecular Biology Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

SUMMARY Human papillomaviruses (HPVs) are small DNA viruses that responsible for significant disease burdens worldwide, including cancers of the cervix, anogenital tract, and oropharynx. HPVs infect stratified epithelia at a variety body locations link their productive life cycles to differentiation host cell. These have evolved sophisticated mechanisms exploit cellular pathways, such as damage repair (DDR), regulate cycles. activate key DDR pathways ATM, ATR, FA, which critical maintaining genomic integrity but often dysregulated in cancers. Importantly, these essential HPV replication undifferentiated cells amplification upon differentiation. The ability modulate not only enables persistence also contributes transformation. In this review, we discuss recent advances understanding by manipulates how depend enhanced topoisomerase activity R-loop formation. Furthermore, strategies manipulate utilized high-risk compared with those used other exhibit similarities distinct differences.

Language: Английский

Citations

0
Human Papillomavirus, Human Immunodeficiency Virus, and Oral Microbiota Interplay in Nigerian Youth (HOMINY): A Prospective Cohort Study Protocol DOI Creative Commons
Esosa Osagie,

Paul Akhigbe,

Nosakhare Lawrence Idemudia

et al.

BMJ Open, Journal Year: 2025, Volume and Issue: 15(2), P. e091017 - e091017

Published: Feb. 1, 2025

Introduction Persistent oral infections with high-risk human papillomavirus (HR-HPV) are a potential cause of most oropharyngeal cancers (OPCs). Oral HR-HPV infection and persistence significantly higher in people living HIV (PLWH). Most data on PLWH come from developed countries or adult cohorts. This study aims to investigate susceptibility among children adolescents (CALHIV) understand the roles perinatal exposure, infection, antiretroviral treatment, microbiome. Methods analysis prospective cohort is ongoing at University Benin Teaching Hospital (UBTH), Nigeria, involving mother-child pairs followed 6-month intervals for 2 years. Participants include aged 9–18 their mothers 18 above. The targets 690 three groups: 230 CALHIV, HIV-exposed but uninfected HIV-unexposed uninfected. rinse, saliva, buccal swabs supragingival plaque samples collected each visit. Blood tested HIV, Hepatitis B virus (HBV) C (HCV), CD4, CD8 full blood counts performed. HPV assessed incidence, persistence, clearance. Statistical analyses look associations between baseline characteristics findings will be conducted using univariable multivariable models repeated high-dimensional microbiome data. All statistical tests two-sided; p value <0.05 indicate significance. Multiple comparisons adjusted False Discovery Rate (FDR) correction control Type I error. Ethics dissemination was approved by Rutgers State (Pro2022000949) UBTH (ADM/E22/A/VOL. VII/14813674). Informed consent obtained all parents/guardians.

Language: Английский

Citations

0
A direct comparative analysis of HPV DNA with single molecule RNA and p16INK4a protein expression in lichen sclerosus: implications for diagnostics and pathogenesis DOI Creative Commons
Georgios Kravvas,

Xue Bo-yu,

Clarisse Gânier

et al.

JID Innovations, Journal Year: 2025, Volume and Issue: unknown, P. 100367 - 100367

Published: March 1, 2025

Language: Английский

Citations

0
Prevalence of Oral Human Papilloma virus infection in an East African HIV/AIDS cohort: A cross-sectional study DOI
Ian Guyton Munabi, Adriane Kamulegeya,

Dunstan Kalanzi

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Background Little is known about the prevalence of Oral Human Papilloma Virus (OHPV) in people living with HIV (PLWHIV) East African region. The objective this study was to document and types OHPV infection a large cohort PLWHIV attending an urban clinic Eastern Africa Methods This cross-sectional among 1,715 participants Makerere University Joint AIDS Program clinic, located Kampala, Uganda, Africa. A salivary sample collected from which DNA extracted subjected Polymerase Chain Reaction (PCR) based typing. Data analysis carried out complete data (n = 1,243) relied on descriptive statistics (frequencies, percentages), bivariate testing multivariate regression modeling, using conventional p < 0.05 statistical significance threshold. Results Participants had mean age 45 (SD 10) years, most (69%) were female, 67% HPV positive. There no association between participants' or gender likelihood them being diagnosed study. type frequently (16%) identified HPV, while 18 (5%) 16 (2.3%) less identified. Most positive samples more than one detected. Conclusion highlights high PLWHIV, detected type, smaller frequencies vaccine targeted 18. Our findings highlight need for continued surveillance typing circulating strains, particularly inform evidence-based preventive strategies. Clinical trial number: not applicable.

Language: Английский

Citations

0
Human papilloma virus (HPV) mediated cancers: an insightful update DOI Creative Commons

Sadaf Khursheed Baba,

Shahad Shahdad Eissa Alblooshi,

R. Yaqoob

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 29, 2025

Language: Английский

Citations

0
The Display between HPV Infection and Host Immunity in Cervical Cancer DOI Creative Commons
Yuanyuan Gu, Tingting Li,

Menglei Zhang

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(12)

Published: Dec. 24, 2024

Most cervical cancers are related to the persistent infections of high-risk Human Papillomavirus (HPV) infections. Increasing evidence has witnessed immunosuppressive effectiveness HPV in oncogenesis steps and progression steps. Here we review immune response HPV-related malignancies discuss crosstalk between HPVs host response. Furthermore, describe identification development current immunotherapies cancer. Above all, hope provide a novel insight display system.

Language: Английский

Citations

1
Distribution of HPV genotypes in Mashhad, Iran: insights from a 2022–2023 study DOI Creative Commons
Arash Letafati,

Masoomeh Noroozi,

Tina Fallah

et al.

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: Oct. 7, 2024

Human papillomavirus (HPV), is one of the main causes cervical cancer and also most common sexually transmitted infections (STIs). HPV responsible for almost all cases plays a principal role in causing other cancers including oropharynx, penis, larynx, oral cavity, anus, vulva, vagina. The study aims to investigate prevalence distribution genotypes among patients referred private laboratories Mashhad, located northeast Iran.

Language: Английский

Citations

0
Apoptotic Caspases Suppress Expression of Endogenous Retroviruses in HPV31+ Cells That Are Associated with Activation of an Innate Immune Response DOI Creative Commons
Caleb J. Studstill, Ning Huang,

Susan A. Sundstrom

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(11), P. 1695 - 1695

Published: Oct. 30, 2024

Avoidance of an immune response is critical to completion the human papillomavirus (HPV) life cycle, which occurs in stratified epithelium and linked epithelial differentiation. We previously demonstrated that high-risk HPVs use apoptotic caspases suppress antiviral innate during productive phase cycle. found caspase-8 caspase-3 a type I IFN-β III IFN-λ by disabling MDA5/MAVS double-stranded RNA (dsRNA) sensing pathway, indicating immunogenic RNAs increase upon differentiation HPV+ cells. In this study, we demonstrate caspase inhibition results aberrant transcription subset endogenous retroviruses (ERVs) have been shown activate IFN through dsRNA-sensing pathways. show ERV accompanied enrichment dsRNA formation. Additionally, robust expression requires activation JAK/STAT-signaling ERVs IFN-inducible. Overall, these suggest model activity blocks reactivation JAK/STAT protecting cells from dsRNAs otherwise would trigger inhibits viral replication.

Language: Английский

Citations

0
The imprint of viral oncoproteins on the variable clinical behavior among human papilloma virus-related oropharyngeal squamous cell carcinomas DOI Creative Commons
Malay K. Sannigrahi,

Lovely Raghav,

Ahmed Diab

et al.

Tumour Virus Research, Journal Year: 2024, Volume and Issue: 18, P. 200295 - 200295

Published: Nov. 1, 2024

Human papilloma virus-related (HPV+) oropharyngeal squamous cell carcinomas (OPSCCs) are variable in their progression, immune landscape, treatment responses, and clinical outcomes. Their behavior is impacted not only by differences host genomic alterations but also diversity levels activity of HPV-encoded oncoproteins. Striking HPV mRNA found among HPV+ OPSCCs likely derive part from variations the structurally diverse mix integrated episomal genomes they often contain. Viral oncoprotein function differential splicing two long polycistronic transcripts HPV16, type within most OPSCCs. Further variation viral arises distinct lineages sub-lineages which encode polymorphisms functionally important portions oncogenes. Here we review limited current knowledge linking expression to that influence OPSCC behavior. We summarize evolving understanding HPV16 physical genome state genetic variants potential contributions function. Addressing considerable remaining challenges defining quantitative qualitative imprint oncoproteins on each holds promise guide personalization therapy for this disease.

Language: Английский

Citations

0