The causal relationship between hepatitis B, immunophenotypes and liver cancer: a Mendelian randomization study DOI Creative Commons

Zhili Cao,

Chunyu Zhang, Shan Chen

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 5, 2025

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths globally, and infection with hepatitis B virus (HBV) one major risk factors for development HCC. However, definitive causal relationship between HBV liver cancer has not been clearly established. In this study, we employed Mendelian randomization (MR) to estimate effect on hepatocellular by using genetic variations as instrumental variables. We obtained summary statistics from genome-wide association studies (GWAS) related B. conducted analysis, variants associated variables cancer. our MR inverse variance weighted (IVW) method performed sensitivity analyses robustness assessments Egger regression median method. Our analysis revealed a significant association, indicating that leads (IVW odds ratio = 2.233, 95% confidence interval 1.844-2.703, P < 0.001). Sensitivity confirmed effect, no evidence horizontal pleiotropy. Similar results were observed across different methods, supporting strong risk. Specifically, CD25 IgD-CD38- cell subset (β 1.15, CI 1.07-1.24, 3.0 × 10^- 4). Additionally, five immune phenotypes significantly HCC risk: HLA DR + monocytes. This study demonstrates risk, highlighting potential factor in carcinoma.

Language: Английский

The causal relationship between hepatitis B, immunophenotypes and liver cancer: a Mendelian randomization study DOI Creative Commons

Zhili Cao,

Chunyu Zhang, Shan Chen

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 5, 2025

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths globally, and infection with hepatitis B virus (HBV) one major risk factors for development HCC. However, definitive causal relationship between HBV liver cancer has not been clearly established. In this study, we employed Mendelian randomization (MR) to estimate effect on hepatocellular by using genetic variations as instrumental variables. We obtained summary statistics from genome-wide association studies (GWAS) related B. conducted analysis, variants associated variables cancer. our MR inverse variance weighted (IVW) method performed sensitivity analyses robustness assessments Egger regression median method. Our analysis revealed a significant association, indicating that leads (IVW odds ratio = 2.233, 95% confidence interval 1.844-2.703, P < 0.001). Sensitivity confirmed effect, no evidence horizontal pleiotropy. Similar results were observed across different methods, supporting strong risk. Specifically, CD25 IgD-CD38- cell subset (β 1.15, CI 1.07-1.24, 3.0 × 10^- 4). Additionally, five immune phenotypes significantly HCC risk: HLA DR + monocytes. This study demonstrates risk, highlighting potential factor in carcinoma.

Language: Английский

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