Akkermansia muciniphila Protects Against Trinitrobenzene Sulfonic Acid Induced Colitis by Inhibiting IL6/STAT3 Pathway DOI
Mingshan Jiang,

Yongbin Jia,

Chunxiang Ma

et al.

Inflammatory Bowel Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Background Inflammatory bowel disease is a long-standing inflammatory disorder that influences the intestinal tract. The intent of this research to explore whether relative abundance Akkermansia muciniphila related IL6/STAT3 pathway and fundamental molecular mechanisms A. on trinitrobenzene sulfonic acid (TNBS)-induced enteritis mouse model, including expression cytokines proteins in signaling pathway. Methods association between was investigated by using mucosal biopsies fecal samples. TNBS-induced colitis models were performed elucidate underlying mechanisms. alteration microbiota organized 16s rRNA sequencing. Results In Crohn’s patients, level STAT3 IL-6 presented negative relationship with muciniphila. IL-6, p-STAT3, downregulated A.m+TNBS group, indicating may inhibit vivo. To investigate potential defensive role supplementation vivo enteritis, 16S sequencing analyze changes composition. results revealed marked increase microbial diversity within muciniphila-treated suggesting beneficial modulation gut microbiome associated supplementation. Conclusions Our findings declared alleviates gastrointestinal inflammation through IL-6/STAT3 This protective effect mediated downregulation STAT3, highlighting mechanism which modulates responses. work disclosed demonstrates influence against vivo, proposing it qualified as unique therapeutic focusing modulating or p-STAT3 treatment colitis.

Language: Английский

Gut virome and its implications in the pathogenesis and therapeutics of inflammatory bowel disease DOI Creative Commons

Yushan Wu,

Rui Cheng, Hao Lin

et al.

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 26, 2025

Language: Английский

Citations

0
Akkermansia muciniphila Protects Against Trinitrobenzene Sulfonic Acid Induced Colitis by Inhibiting IL6/STAT3 Pathway DOI
Mingshan Jiang,

Yongbin Jia,

Chunxiang Ma

et al.

Inflammatory Bowel Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Abstract Background Inflammatory bowel disease is a long-standing inflammatory disorder that influences the intestinal tract. The intent of this research to explore whether relative abundance Akkermansia muciniphila related IL6/STAT3 pathway and fundamental molecular mechanisms A. on trinitrobenzene sulfonic acid (TNBS)-induced enteritis mouse model, including expression cytokines proteins in signaling pathway. Methods association between was investigated by using mucosal biopsies fecal samples. TNBS-induced colitis models were performed elucidate underlying mechanisms. alteration microbiota organized 16s rRNA sequencing. Results In Crohn’s patients, level STAT3 IL-6 presented negative relationship with muciniphila. IL-6, p-STAT3, downregulated A.m+TNBS group, indicating may inhibit vivo. To investigate potential defensive role supplementation vivo enteritis, 16S sequencing analyze changes composition. results revealed marked increase microbial diversity within muciniphila-treated suggesting beneficial modulation gut microbiome associated supplementation. Conclusions Our findings declared alleviates gastrointestinal inflammation through IL-6/STAT3 This protective effect mediated downregulation STAT3, highlighting mechanism which modulates responses. work disclosed demonstrates influence against vivo, proposing it qualified as unique therapeutic focusing modulating or p-STAT3 treatment colitis.

Language: Английский

Citations

0