Marine Phytoplankton Bioactive Lipids and Their Perspectives in Clinical Inflammation DOI Creative Commons
Edoardo Andrea Cutolo, Rosanna Campitiello, Valeria Di Dato

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(2), P. 86 - 86

Published: Feb. 17, 2025

Marine phytoplankton is an emerging source of immunomodulatory bioactive lipids (BLs). Under physiological growth conditions and upon stress challenges, several eukaryotic microalgal species accumulate lipid metabolites that resemble the precursors animal mediators inflammation: eicosanoids prostaglandins. Therefore, marine could serve as a biotechnological platform to produce functional BLs with therapeutic applications in management chronic inflammatory diseases other clinical conditions. However, be commercially competitive, lipidic precursor yields should enhanced. Beside tailoring cultivation native producers, genetic engineering feasible strategy accrue production introduce heterologous biosynthetic pathways hosts. Here, we present state-of-the-art research on from discuss synthetic biology approaches boost their light-driven biosynthesis.

Language: Английский

Marine Phytoplankton Bioactive Lipids and Their Perspectives in Clinical Inflammation DOI Creative Commons
Edoardo Andrea Cutolo, Rosanna Campitiello, Valeria Di Dato

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(2), P. 86 - 86

Published: Feb. 17, 2025

Marine phytoplankton is an emerging source of immunomodulatory bioactive lipids (BLs). Under physiological growth conditions and upon stress challenges, several eukaryotic microalgal species accumulate lipid metabolites that resemble the precursors animal mediators inflammation: eicosanoids prostaglandins. Therefore, marine could serve as a biotechnological platform to produce functional BLs with therapeutic applications in management chronic inflammatory diseases other clinical conditions. However, be commercially competitive, lipidic precursor yields should enhanced. Beside tailoring cultivation native producers, genetic engineering feasible strategy accrue production introduce heterologous biosynthetic pathways hosts. Here, we present state-of-the-art research on from discuss synthetic biology approaches boost their light-driven biosynthesis.

Language: Английский

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