MicroRNAs in Hepatocellular Carcinoma Pathogenesis: Insights into Mechanisms and Therapeutic Opportunities
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9393 - 9393
Published: Aug. 29, 2024
Hepatocellular
carcinoma
(HCC)
presents
a
significant
global
health
burden,
with
alarming
statistics
revealing
its
rising
incidence
and
high
mortality
rates.
Despite
advances
in
medical
care,
HCC
treatment
remains
challenging
due
to
late-stage
diagnosis,
limited
effective
therapeutic
options,
tumor
heterogeneity,
drug
resistance.
MicroRNAs
(miRNAs)
have
attracted
substantial
attention
as
key
regulators
of
pathogenesis.
These
small
non-coding
RNA
molecules
play
pivotal
roles
modulating
gene
expression,
implicated
various
cellular
processes
relevant
cancer
development.
Understanding
the
intricate
network
miRNA-mediated
molecular
pathways
is
essential
for
unraveling
complex
mechanisms
underlying
hepatocarcinogenesis
developing
novel
approaches.
This
manuscript
aims
provide
comprehensive
review
recent
experimental
clinical
discoveries
regarding
role
miRNAs
influencing
hallmarks
HCC,
well
their
promising
utility
potential
targets.
Language: Английский
A circuit for secretion‐coupled cellular autonomy in multicellular eukaryotic cells
Molecular Systems Biology,
Journal Year:
2023,
Volume and Issue:
19(4)
Published: March 1, 2023
Cancers
represent
complex
autonomous
systems,
displaying
self-sufficiency
in
growth
signaling.
Autonomous
is
fueled
by
a
cancer
cell's
ability
to
"secrete-and-sense"
factors
(GFs):
poorly
understood
phenomenon.
Using
an
integrated
computational
and
experimental
approach,
here
we
dissect
the
impact
of
feedback-coupled
GTPase
circuit
within
secretory
pathway
that
imparts
secretion-coupled
autonomy.
The
assembled
when
Ras-superfamily
monomeric
Arf1,
heterotrimeric
Giαβγ
their
corresponding
GAPs
GEFs
are
coupled
GIV/Girdin,
protein
known
fuel
aggressive
traits
diverse
cancers.
One
forward
two
key
negative
feedback
loops
create
closed-loop
control,
allow
GTPases
coregulate
each
other,
convert
expected
switch-like
behavior
Arf1-dependent
secretion
into
unexpected
dose-response
alignment
sensing
secretion.
Such
translates
cell
survival
self-sustained
stimulus-proportionate
Proteomic
studies
protein-protein
interaction
network
analyses
pinpoint
GFs
(e.g.,
epidermal
GF)
as
stimuli
for
such
self-sustenance.
Findings
highlight
how
enhanced
coupling
biological
switches
cells
critical
multiscale
control
achieve
autonomy
factors.
Language: Английский
ANTICANCER LIPID-BASED DRUG DELIVERY SYSTEMS: BASIC KNOWLEDGE AND RECENT APPLICATIONS
Nano TransMed,
Journal Year:
2024,
Volume and Issue:
unknown, P. 100054 - 100054
Published: Oct. 1, 2024
Language: Английский
Interlinked switch circuits of biological intelligence
Trends in Biochemical Sciences,
Journal Year:
2024,
Volume and Issue:
49(4), P. 286 - 289
Published: Feb. 9, 2024
Eukaryotic
cells
learn
and
adapt
via
unknown
network
architectures.
Recent
work
demonstrated
a
circuit
of
two
GTPases
used
by
to
overcome
growth
factor
scarcity,
encouraging
our
view
that
artificial
biological
intelligence
share
strikingly
similar
design
principles
function
as
deep
reinforcement
learning
(RL)
agents
in
uncertain
environments.
Language: Английский
In vitro evidence for the potential of EGFR inhibitors to decrease the TGF-β1-induced dispersal of circulating tumour cell clusters mediated by EGFR overexpression
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Aug. 28, 2024
Most
cancer-related
deaths
are
due
to
the
spread
of
tumour
cells
throughout
body-a
process
known
as
metastasis.
While
in
vasculature,
these
referred
circulating
(CTCs)
and
can
be
found
either
single
or
clusters
(often
including
platelets),
with
latter
having
highest
metastatic
potential.
However,
biology
CTC
is
poorly
understood,
there
no
therapies
that
specifically
target
them.
We
previously
developed
an
vitro
model
system
for
proposed
a
new
extravasation
involves
cluster
dissociation,
adherence,
single-cell
invasion
response
TGF-β1
released
by
platelets.
Here,
we
investigated
TGF-β1-induced
gene
expression
changes
this
model,
focusing
on
genes
which
targeted
drugs
available.
In
addition
upregulation
signalling
pathway,
(i)
EGF/EGFR
those
coding
EGFR
several
ligands,
were
also
induced,
(ii)
Erlotinib
Osimertinib,
two
therapeutic
EGFR/tyrosine
kinase
inhibitors,
decreased
adherence
cluster-like
line
despite
expressing
wild-type
EGFR.
Overall,
suggest
inhibitors
have
potential
decrease
dispersal
respond
overexpress
(irrespective
its
status)
thus
could
improve
patient
survival.
Language: Английский
A Multiomic Analysis Reveals How Breast Cancers Disseminated to the Bone Marrow Acquire Aggressive Phenotypes through Tumor-Stroma Tunnels
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2023,
Volume and Issue:
unknown
Published: March 21, 2023
Estrogen
receptor-positive
(ER+)
breast
cancer
commonly
disseminates
to
bone
marrow,
where
interactions
with
mesenchymal
stromal
cells
(MSCs)
shape
disease
trajectory.
We
modeled
these
tumor-MSC
co-cultures
and
used
an
integrated
transcriptome-proteome-network-analyses
workflow
identify
a
comprehensive
catalog
of
contact-induced
changes.
Conditioned
media
from
MSCs
failed
recapitulate
genes
proteins,
some
borrowed
others
tumor-intrinsic,
induced
in
by
direct
contact.
Protein-protein
interaction
networks
revealed
the
rich
connectome
between
'borrowed'
'intrinsic'
components.
Bioinformatics
prioritized
one
components,
Language: Английский