Sulfation pathways in times of change DOI Creative Commons
Jonathan Wolf Mueller, Daniela Fietz, Irundika H.K. Dias

et al.

Essays in Biochemistry, Journal Year: 2024, Volume and Issue: 68(4), P. 379 - 382

Published: Dec. 1, 2024

Abstract Sulfation pathways are an essential part of overall sulfur metabolism. mainly about sulfate activation, and the making breaking biological esters. This special issue features some extended reflection on what was presented at SUPA 2023 meeting Pathways. Novel insights into synthesis analytics sulfate, sulfated conjugates, protein persulfides presented. Oxysterol sulfates as emerging sulfo-metabolites. enzymes discussed in various disease settings. also presents polysaccharide sulfotransferases their functional characterization. Finally, cytoplasmic highlighted with regards to impact DNA-modification, context endocrine disruptors. All all, thought-provoking findings, potential guide stimulate future research field sulfation beyond.

Language: Английский

Genome-wide identification and transcriptome-based expression profiling of Sulfotransferase superfamily genes in Mus musculus DOI Creative Commons
Junaid Habib Khan,

Samra Farooq,

S Shafqat

et al.

Published: April 1, 2025

Language: Английский

Citations

0
Design and synthesis of spiro[pyrrolidine-3,3'-quinoline]-2,2'-dione derivatives as novel antifungal agents targeting chitin synthase DOI

Yan Long,

Xinglong Yang,

Yajie Xu

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 279, P. 116895 - 116895

Published: Sept. 19, 2024

Language: Английский

Citations

2
Sulphotransferase-mediated toxification of chemicals in mouse models: effect of knockout or humanisation of SULT genes DOI Creative Commons
Hansruedi Glatt, Walter Meinl

Essays in Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Abstract Cytosolic sulphotransferase (SULT) enzymes catalyse reactions involved in xenobiotic elimination and hormone regulation. However, SULTs can also generate electrophilic reactive intermediates from certain substrates, including the activation of carcinogens. Here, we review toxicological studies mouse strains with SULT status altered by genetic modification. Knockout have been constructed for Sult1a1, 1d1, 1e1, 2b1 4a1. In addition, transgenic are available human SULT1A1/2. Among knockout strains, reduced fertility (Sult1e1) early postnatal death (Sult4a1) were observed. contrast, Sult1a1 or Sult1d1 knockouts SULT1A1/2 transgenics healthy showed no obvious deficiencies. These used 13 chemicals. Manipulation system dramatically adverse effects many compounds; thus, very large differences levels DNA adducts formed liver other tissues seen some chemicals – up to 99.2% decreases 83-fold increases transgenics. cases, these changes restricted which corresponding expressed, arguing local activation. compounds, kidney was an important target tissue, due active transfer that organ, via circulation, sulphuric acid esters.

Language: Английский

Citations

1
Sulfation pathways in times of change DOI Creative Commons
Jonathan Wolf Mueller, Daniela Fietz, Irundika H.K. Dias

et al.

Essays in Biochemistry, Journal Year: 2024, Volume and Issue: 68(4), P. 379 - 382

Published: Dec. 1, 2024

Abstract Sulfation pathways are an essential part of overall sulfur metabolism. mainly about sulfate activation, and the making breaking biological esters. This special issue features some extended reflection on what was presented at SUPA 2023 meeting Pathways. Novel insights into synthesis analytics sulfate, sulfated conjugates, protein persulfides presented. Oxysterol sulfates as emerging sulfo-metabolites. enzymes discussed in various disease settings. also presents polysaccharide sulfotransferases their functional characterization. Finally, cytoplasmic highlighted with regards to impact DNA-modification, context endocrine disruptors. All all, thought-provoking findings, potential guide stimulate future research field sulfation beyond.

Language: Английский

Citations

0