Utilization of SuperCYPsPred Software for Predicting Drug Interactions Mediated by Cytochrome P450 Isoenzymes in Elderly Patients Receiving Polypharmacy DOI Creative Commons
Furqan M. Abdulelah, Ali Hamid AbdulHussein, Mohamed Abdul Wahab Alwardi

et al.

Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ), Journal Year: 2025, Volume and Issue: 8(1), P. 236 - 242

Published: March 19, 2025

Background: Increasing polypharmacy and complicated prescription regimens raise the likelihood of CYP-mediated drug-drug interactions (DDIs) in older people. Objective: To assess incidence DDIs people with examine correlation between medication dispensation these this high-risk group. Methods: A cross-sectional 17-week analysis was performed, including consecutive new patients aged 65 years over who were undergoing (defined as use more than five medications) at a community pharmacy. The profiles individuals evaluated using SuperCYPsPred software UpToDate® Lexidrug. frequency possible evaluated. pharmacists' judgments to suggest adjustments based on documented. Results: prevalence identified among 220 persons 84.5%. Moderate severity predominant significant kind interaction (2.70±3.157). linear regression performed predict drug number drugs. association has been (F(1,14)= 67.789, p<0.001). CYP isoenzyme CYP3A4 34.6%, followed by CYP2C9 21.4% CYP2D6 15.7%, no notable gender differences. Conclusion: have least one DDI. Elderly adults taking or medicines require frequent care owing fourfold greater chance interactions.

Language: Английский

Utilization of SuperCYPsPred Software for Predicting Drug Interactions Mediated by Cytochrome P450 Isoenzymes in Elderly Patients Receiving Polypharmacy DOI Creative Commons
Furqan M. Abdulelah, Ali Hamid AbdulHussein, Mohamed Abdul Wahab Alwardi

et al.

Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ), Journal Year: 2025, Volume and Issue: 8(1), P. 236 - 242

Published: March 19, 2025

Background: Increasing polypharmacy and complicated prescription regimens raise the likelihood of CYP-mediated drug-drug interactions (DDIs) in older people. Objective: To assess incidence DDIs people with examine correlation between medication dispensation these this high-risk group. Methods: A cross-sectional 17-week analysis was performed, including consecutive new patients aged 65 years over who were undergoing (defined as use more than five medications) at a community pharmacy. The profiles individuals evaluated using SuperCYPsPred software UpToDate® Lexidrug. frequency possible evaluated. pharmacists' judgments to suggest adjustments based on documented. Results: prevalence identified among 220 persons 84.5%. Moderate severity predominant significant kind interaction (2.70±3.157). linear regression performed predict drug number drugs. association has been (F(1,14)= 67.789, p<0.001). CYP isoenzyme CYP3A4 34.6%, followed by CYP2C9 21.4% CYP2D6 15.7%, no notable gender differences. Conclusion: have least one DDI. Elderly adults taking or medicines require frequent care owing fourfold greater chance interactions.

Language: Английский

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