Microsporidian infection of mosquito larvae changes the host-associated microbiome towards the synthesis of antimicrobial factors

Parasites & Vectors, Journal Year: 2025, Volume and Issue: 18(1)

Published: May 17, 2025

Language: Английский

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The Role of Noncoding RNA in the Transmission and Pathogenicity of Flaviviruses

Viruses, Journal Year: 2024, Volume and Issue: 16(2), P. 242 - 242

Published: Feb. 2, 2024

Noncoding RNAs (ncRNAs) constitute a class of RNA molecules that lack protein-coding capacity. ncRNAs frequently modulate gene expression through specific interactions with target proteins or messenger RNAs, thereby playing integral roles in wide array cellular processes. The Flavivirus genus comprises several significant members, such as dengue virus (DENV), Zika (ZIKV), and yellow fever (YFV), which have caused global outbreaks, resulting high morbidity mortality human populations. life cycle arthropod-borne flaviviruses encompasses their transmission between hematophagous insect vectors mammalian hosts. During this process, complex three-way interplay occurs among the pathogen, vector, host, exerting critical regulatory influence. not only crucial mechanism has emerged from coevolution viruses hosts but also hold potential antiviral targets for controlling flavivirus epidemics. This review introduces biogenesis flavivirus-derived summarizes viral replication, vector-mediated transmission, innate immunity, pathogenicity. A profound comprehension will help formulate efficacious prophylactic therapeutic strategies against flavivirus-related diseases.

Language: Английский

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Comprehensive Profiling of Bacterial Microbiota in Aedes aegypti and Culex quinquefasciatus Mosquitoes from Odisha, India Using Full-Length 16S rRNA Gene Sequencing

Indian Journal of Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Language: Английский

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Ixodiphagus hookeri (Hymenoptera: Encyrtidae) and Tick-Borne Pathogens in Ticks with Sympatric Occurrence (and Different Activities) in the Slovak Karst National Park (Slovakia), Central Europe

Pathogens, Journal Year: 2024, Volume and Issue: 13(5), P. 385 - 385

Published: May 7, 2024

Ticks are involved in the transmission a plethora of pathogens. To effectively control ticks and mitigate risks associated with tick-borne diseases, it is important to implement tick measures. These may include use acaricides as well development implementation an alternative, environmentally friendly management program that practices such habitat modification or establishing biological control. Ixodiphagus hookeri Howard tick-specific parasitoid wasp predates on several species ixodid could contribute population. This work aimed detect presence wasps (Ixodidae) using genetic approaches. Several genera Ixodes, Haemaphysalis, Dermacentor, sympatric occurrence Slovak Karst National Park southeastern Slovakia, were screened for genus Ixodiphagus. The DNA parasitoids was detected four from three genera. presents first molecular detection two Dermacentor species, identification Ixodes ricinus Haemaphysalis concinna area. In given area, observed I. H. hyper-parasitized by wasps. Moreover, here can parasitize some which less significance human animal health (as they transmit fewer pathogens).

Language: Английский

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Role of Gut Microbiota in Dengue

Reviews in Medical Virology, Journal Year: 2024, Volume and Issue: 34(5)

Published: Aug. 30, 2024

ABSTRACT Dengue is a disease caused by flavivirus (DENV) and transmitted the bite of mosquito, primarily Aedes aegypti albopictus species. Previous studies have demonstrated relationship between host gut microbiota evolution dengue. It seems to be bidirectional relationship, in which DENV can affect inducing alterations related intestinal permeability, leading release molecules from dysbiosis that influence The role angiotensin II (Ang II) microbiota/dengue not well understood, but it known renin‐angiotensin system (RAS) present tract interacts with microbiota. possible effect Ang on microbiota/Ang II/dengue summarised as follows: presence induced hypertension, increase angiotensinogen, chymase, microRNAs during disease, induction vascular dysfunction, production trimethylamine N‐oxide brain/microbiota all are elements dengue could part interactions. These findings suggest potential use synthesis blockers AT1 receptor antagonists therapeutic drugs

Language: Английский

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Aedes Mosquito Virome in Southwestern Cameroon: Lack of Core Virome, but a Very Rich and Diverse Virome in Ae. Africanus Compared to Other Aedes Species

Published: June 14, 2024

In Cameroon, Aedes mosquitoes transmit various arboviruses, posing significant health risks. We aimed to characterize the virome in southwestern Cameroon and identify potential core viruses which might be associated with vector competence. A total of 398 were collected from four locations (Bafoussam, Buea, Edea Yaounde). albopictus dominated all sites except for Bafoussam where africanus prevailed. Metagenomic analyses grouped per species into 54 pools revealed notable differences eukaryotic viromes between Ae. albopictus, former exhibiting greater richness diversity. Thirty-seven virus 16 families identified, including six novel near complete genome sequences. Seven further quantified individual via qRT-PCR. Although none them could identified as viruses, Guangzhou sobemo-like mosquito solemovirus highly prevalent regionally africanus, respectively. This study highlights diverse Cameroon. Despite their shared Genus, exhibit limited viral sharing, varying abundance prevalence across locations. an understudied vector, harbors a rich virome, suggesting implications arbovirus

Language: Английский

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Microbiota profile in organs of the horseflies (Diptera: Tabanidae) in Northeastern China

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 24, 2024

Tabanids, commonly known as horseflies and belonging to the family Tabanidae, are blood-feeding arthropods (BFA) found worldwide. They for their ability mechanically biologically transmit various animal pathogens. Tabanids potential vectors diseases such

Language: Английский

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Starving the Beast: Limiting Coenzyme A Biosynthesis to Prevent Disease and Transmission in Malaria

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 13915 - 13915

Published: Sept. 10, 2023

Malaria parasites must acquire all necessary nutrients from the vertebrate and mosquito hosts to successfully complete their life cycle. Failure these can limit or even block parasite development presents a novel target for malaria control. One such essential nutrient is pantothenate, also known as vitamin B5, which cannot synthesize de novo required synthesis of coenzyme A (CoA) in parasite. This review examines pantothenate CoA biosynthesis pathway human–mosquito–malaria triad explores possible approaches leverage both human hosts. includes discussion sources mosquito, human, parasite, examining diverse strategies used by substrates across stages host resource pools drugs alternative being studied disrupt The latter antimalarial analogs, pantothenamides, that have been developed this during erythrocytic stages. In addition parasite-targeted drugs, we studies mosquito-targeted allosteric enzymatic regulators pantazines an approach availability subsequently deprive nutrient.

Language: Английский

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Orthoflavivirus Lammi in Russia: Possible Transovarial Transmission and Trans-Stadial Survival in Aedes cinereus (Diptera, Culicidae)

Viruses, Journal Year: 2024, Volume and Issue: 16(4), P. 527 - 527

Published: March 28, 2024

In the last few years, there has been a dramatic increase in number of discovered viruses that are transmitted by arthropods. Some them pathogenic for humans and mammals, potential others is unknown. The genus

Language: Английский

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Host skin immunity to arthropod vector bites: from mice to humans

Frontiers in Tropical Diseases, Journal Year: 2024, Volume and Issue: 5

Published: May 1, 2024

Infections caused by vector-borne pathogens impose a significant burden of morbidity and mortality in global scale. In their quest for blood, hematophagous arthropods penetrate the host skin may transmit bite. These are deposited along with saliva complex mixture vector derived factors. Hematophagous arthopod vectors have evolved array adaptations to modulate immune response at bite site primary goal improve blood feeding, which been exploited throughout evolution these enhance infection establishment host. While this paradigm has firmly established mouse models, comparable data from human studies scarce. Here we review how bites animal models is hijacked microbes promote pathogenesis. We mainly explored four distinct vector-pathogen pairs health importance: sand flies Leishmania parasites, Ixodes scapularis ticks Borrelia burgdorferi , Aedes aegypti mosquitoes arboviruses, Anopheles gambiae mosquitos Plasmodium parasites. Finally, outline critical it field biology shift rodent clinical focused on interface vector-pathogen-host system push further frontiers knowledge field.

Language: Английский

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