Sex-specific habenular dysconnectivity in patients with late-life depression DOI Creative Commons
Ting Su,

Ben Chen,

Qin Liu

et al.

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 4, 2025

There are significant sex differences in the prevalence, symptom presentation, treatment response and brain abnormalities of patients with late-life depression (LLD). The functional connectivity habenula has been associated depressive symptoms cognitive impairments LLD. However, habenular patterns among LLD remain unclear. One hundred fourteen 75 healthy controls (HCs) were included present study. Resting-state magnetic resonance imaging was used to analyse static dynamic (sFC dFC) habenula. interactions between diagnosis (LLD vs. HCs) for dFC left insula, precentral gyrus, angular middle frontal gyrus right temporal gyrus. Pairwise comparisons revealed a trend HC males > females < connections Conversely, found pole. Furthermore, there interaction sFC fusiform trends females, males, females. Regression analysis that habenular-left insular long-delay memory working males; habenular-right pole information processing speed Sex moderated relationships function (global cognition, delay-recalled memory) insula. In conclusions, this study sex-specific alterations patients, these various functions manner. These findings provide neurobiological basis understanding patients.

Language: Английский

Sex-specific differences in peripheral blood metabolites and biological functions in major depressive disorder: a systematic review and meta-analysis DOI
Zhengyang Wang, Yajie Xiang,

Ruozhi Dang

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 170, P. 106052 - 106052

Published: Feb. 5, 2025

Language: Английский

Citations

0
Sex-specific habenular dysconnectivity in patients with late-life depression DOI Creative Commons
Ting Su,

Ben Chen,

Qin Liu

et al.

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 4, 2025

There are significant sex differences in the prevalence, symptom presentation, treatment response and brain abnormalities of patients with late-life depression (LLD). The functional connectivity habenula has been associated depressive symptoms cognitive impairments LLD. However, habenular patterns among LLD remain unclear. One hundred fourteen 75 healthy controls (HCs) were included present study. Resting-state magnetic resonance imaging was used to analyse static dynamic (sFC dFC) habenula. interactions between diagnosis (LLD vs. HCs) for dFC left insula, precentral gyrus, angular middle frontal gyrus right temporal gyrus. Pairwise comparisons revealed a trend HC males > females < connections Conversely, found pole. Furthermore, there interaction sFC fusiform trends females, males, females. Regression analysis that habenular-left insular long-delay memory working males; habenular-right pole information processing speed Sex moderated relationships function (global cognition, delay-recalled memory) insula. In conclusions, this study sex-specific alterations patients, these various functions manner. These findings provide neurobiological basis understanding patients.

Language: Английский

Citations

0