International Journal of Biology Pharmacy and Allied Sciences,
Journal Year:
2023,
Volume and Issue:
12(10 (SPECIAL ISSUE))
Published: Oct. 12, 2023
This
systematic
review
highlights
the
potential
of
antioxidants
as
therapeutic
intervention
in
dry
eye
disease.Preclinical
reports
assessing
effect
plant
based
and
synthetic
against
disease
was
collected
from
online
electronic
databases
like
Scopus,
PubMed,
Science
direct,
DOAJ,
Jgate.The
protocol
registered
on
PROSPERO,
registration
no.CRD42023420934.The
followed
PRISMA
approach
for
including
all
were
appraised
risk
bias
using
SYRCLE's
RoB
tool.From
search
results
26
articles
met
inclusion
criteria
review.These
analyzed
rodent
species
strain
used,
which
improved
tear
volume,
restore
conjunctival
goblet
cells,
amelioration
inflammatory
cytokines
TNF-α,
IL-1β,
NLRP3
reduction
oxidative
stress.The
studies
reported
this
insinuates
target
their
mechanism
action
stress,
corneal
irregularity,
ocular
surface
inflammation
apoptosis
secretion.These
repots
compositely
suggest
that
can
ameliorate
negative
effects
improve
secretion
to
maintain
homeostasis.
Critical Reviews in Environmental Science and Technology,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 21
Published: Nov. 20, 2024
Microplastics
(MPs)
have
been
detected
in
human
tissues
and
body
fluids,
triggering
obvious
toxicity
to
health.
However,
the
adverse
effects
of
MPs
on
ocular
surface
were
usually
ignored,
but
receiving
increasing
attention
now.
The
surface,
outermost
layer
eye,
acts
as
mechanical
barrier
exotic
substances
minimize
interior
damage.
Daily
exposure
was
considered
increase
risks
corneal
injury.
In
this
review,
we
summarized
sources
which
are
most
likely
enter
explored
potential
detrimental
impact
their
adherent
contaminants,
well
factors
influencing
proposed
strategies
reduce
MPs.
results
showed
that
air,
personal
care
products,
contact
lenses
main
Furthermore,
additives
adsorbents
contribute
more
toxicities,
causing
some
diseases
like
dry
pterygium,
conjunctivitis,
keratitis.
polymer
type,
size,
degree
aging,
activities
nature,
affect
Reducing
plastic
consumption,
eliminating
environmental
MPs,
strengthening
protection
important
ways
toxicity.
Collectively,
review
provides
new
insights
into
health
risk
prevention
control.
International Journal of Biology Pharmacy and Allied Sciences,
Journal Year:
2023,
Volume and Issue:
12(10 (SPECIAL ISSUE))
Published: Oct. 12, 2023
This
systematic
review
highlights
the
potential
of
antioxidants
as
therapeutic
intervention
in
dry
eye
disease.Preclinical
reports
assessing
effect
plant
based
and
synthetic
against
disease
was
collected
from
online
electronic
databases
like
Scopus,
PubMed,
Science
direct,
DOAJ,
Jgate.The
protocol
registered
on
PROSPERO,
registration
no.CRD42023420934.The
followed
PRISMA
approach
for
including
all
were
appraised
risk
bias
using
SYRCLE's
RoB
tool.From
search
results
26
articles
met
inclusion
criteria
review.These
analyzed
rodent
species
strain
used,
which
improved
tear
volume,
restore
conjunctival
goblet
cells,
amelioration
inflammatory
cytokines
TNF-α,
IL-1β,
NLRP3
reduction
oxidative
stress.The
studies
reported
this
insinuates
target
their
mechanism
action
stress,
corneal
irregularity,
ocular
surface
inflammation
apoptosis
secretion.These
repots
compositely
suggest
that
can
ameliorate
negative
effects
improve
secretion
to
maintain
homeostasis.
