Multifunctional hydrogel microspheres regulate the balance of osteoblastic-osteoclastogenesis to treat osteoporotic bone defects by the NFATc1/RANKL/MAPK signaling

Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112195 - 112195

Published: Feb. 1, 2025

Language: Английский

---

Atomic-scale study of lattice distortion and oxygen-rich environment impact on the surface degradation dynamics of zinc-based alloys

Computational Materials Science, Journal Year: 2025, Volume and Issue: 252, P. 113797 - 113797

Published: March 3, 2025

Language: Английский

---

Degradation behavior of porous magnesium alloy scaffold under the low-intensity pulsed ultrasound intervention and their effect on bone defects repair

Regenerative Biomaterials, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 1, 2025

Abstract Biodegradable porous magnesium alloy (pMg) scaffolds hold significant potential for repair of bone defects owing to favorable mechanical properties and biocompatibility. However, a critical challenge remains in matching the degradation rate pMg with pace regeneration. Low-intensity pulsed ultrasound (LIPUS) has emerged as promising therapeutic strategy enhance repair. In this study, femoral Sprague–Dawley rats were implanted scaffolds, LIPUS was applied defect sites post-operatively. This study primarily investigated behavior vivo experiments, well their reparative effects on under intervention. analysis revealed that intervention accelerated by loosening layer, making it more susceptible erosion. Concurrently, enhanced accumulation beneficial calcium phosphorus compounds surface scaffolds. Furthermore, + group exhibited formation mineralization around site compared alone, attributed increasing osteocalcin (OCN) type I collagen (COL-I) reduction osteolysis LIPUS-induced osteogenesis effect. At 24-week post-surgery, hardness value (HV) regeneration had 15% increase approached HV healthy bone. conclusion, promotion tissue growth conjunction offers novel clinical defects.

Language: Английский

---

Toxicity, Irritation, and Allergy of Metal Implants: Historical Perspective and Modern Solutions

Coatings, Journal Year: 2025, Volume and Issue: 15(3), P. 361 - 361

Published: March 20, 2025

The widespread adoption of metal implants in orthopaedics and dentistry has revolutionized medical treatments, but concerns remain regarding their biocompatibility, toxicity, immunogenicity. This study conducts a comprehensive literature review traditional biomaterials used orthopaedic surgery traumatology, with particular focus on historical development biological interactions. Research articles were gathered from PubMed Web Science databases using keyword combinations such as “toxicity, irritation, allergy, biomaterials, corrosion, implants, surgery, biocompatible materials, steel, alloys, material properties, applications, implantology, surface modification”. An initial pool 400 was screened by independent reviewers based predefined inclusion exclusion criteria, resulting 160 relevant covering research 1950 to 2025. paper explores the electrochemical processes metals like iron, titanium, aluminium, cobalt, molybdenum, nickel, chromium post-implantation, which cause ion release wear debris formation. These ions interact molecules, triggering localized inflammatory responses, immune-mediated hypersensitivity. Unlike existing reviews, this highlights how metal–protein interactions can form antigenic complexes, contributing delayed hypersensitivity complications peri-implant osteolysis implant failure. While titanium is traditionally considered bioinert, emerging evidence suggests that under certain conditions, even inert induce adverse effects. Furthermore, emphasizes role oxidative stress, illustrating systemic toxicity contribute long-term health risks. It also uncovers underappreciated genotoxic cytotoxic effects cellular metabolism, shedding light potential repercussions. By integrating rigorous methodological approach an in-depth exploration metal-induced offers more nuanced perspective complex interplay between human biology, advancing discourse safety innovation.

Language: Английский

---

Impact of Zn/Sn Variations on the Microstructure, Mechanical Properties, and Biocorrosion of T4-Treated Mg-0.5Ca-Zn-(Sn) Alloys for Orthopaedic Implants

Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown, P. 130834 - 130834

Published: April 1, 2025

Language: Английский

---

Microstructural Control of Zn Alloy by Melt Spinning - A Novel Approach Towards Fabrication of Advanced Biodegradable Biomedical Materials

Materials Science and Engineering A, Journal Year: 2025, Volume and Issue: unknown, P. 148347 - 148347

Published: April 1, 2025

Language: Английский

---

3D‐Printed Scaffolds for Cranial Bone Regeneration: A Systematic Review of Design, Materials, and Computational Optimization

Biotechnology and Bioengineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

ABSTRACT Cranial bone defects from trauma, congenital conditions, or surgery are challenging to treat due the skull's limited regeneration. Traditional methods like autografts and allografts have drawbacks, including donor site issues poor integration. 3D‐printed scaffolds provide a patient‐specific alternative, improving regeneration This review evaluates advancements in for cranial regeneration, focusing on fabrication techniques, material innovations, structural optimization while assessing their preclinical clinical potential. A systematic literature search (2014–2024) was conducted using PubMed other databases. Studies addressing scaffold properties such as porosity, pore interconnectivity, mechanical stability were included, non‐cranial studies excluded. Advances 3D printing enabled with optimized architecture enhance support, nutrient transport. Bioceramics, polymers, composites mimic native properties, bioactive coatings further improve osteogenesis. However, translation insufficient customization remain challenges. Further trials crucial overcoming barriers fabrication, bridging gap between research applications.

Language: Английский

---

Mechanical and Computational Fluid Dynamic Models for Magnesium-Based Implants

Materials, Journal Year: 2024, Volume and Issue: 17(4), P. 830 - 830

Published: Feb. 8, 2024

Today, mechanical properties and fluid flow dynamic analysis are considered to be two of the most important steps in implant design for bone tissue engineering. The behavior is characterized by Young’s modulus, which must have a value close that human bone, while from dynamics point view, permeability wall shear stress parameters directly linked cell growth, adhesion, proliferation. In this study, we proposed simple geometries with three-dimensional pore network dedicated manufacturing route based on titanium wire waving procedure used as an intermediary step Mg-based fabrication. Implant deformation under different static loads, von Mises stresses, safety factors were investigated using finite element analysis. was computed Darcy’s law following computational simulations and, pressure drop, numerically estimated. It concluded both models exhibited trabecular reduced stresses within biological range. As general finding, could useful orthopedics defect treatment numerical analyses because they mimic properties.

Language: Английский

---

Surface engineering of pure magnesium in medical implant applications

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e31703 - e31703

Published: May 23, 2024

This review comprehensively surveys the latest advancements in surface modification of pure magnesium (Mg) recent years, with a focus on various cost-effective procedures, comparative analyses, and assessments outcomes, addressing merits drawbacks Mg its alloys. Diverse economically feasible methods for modification, such as hydrothermal processes ultrasonic micro-arc oxidation (UMAO), are discussed, emphasizing their exceptional performance enhancing properties. The attention is directed towards biocompatibility corrosion resistance Mg, underscoring remarkable efficacy techniques Ca-deficientca-deficient hydroxyapatite (CDHA)/MgF

Language: Английский

---

Challenges and Pitfalls of Research Designs involving Magnesium-Based Biomaterials: An Overview

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6242 - 6242

Published: June 5, 2024

Magnesium-based biomaterials hold remarkable promise for various clinical applications, offering advantages such as reduced stress-shielding and enhanced bone strengthening vascular remodeling compared to traditional materials. However, ensuring the quality of preclinical research is crucial development these implants. To achieve implant success, an understanding cellular responses post-implantation, proper model selection, good study design are crucial. There several challenges reaching a safe effective translation laboratory findings into practice. The utilization Mg-based biomedical devices eliminates need biomaterial removal surgery post-healing mitigates adverse effects associated with permanent implantation. high corrosion rate implants poses unexpected degradation, structural failure, hydrogen evolution, alkalization, cytotoxicity. biocompatibility degradability materials based on magnesium have been studied by many researchers in vitro; however, evaluations addressing impact material vivo still be improved. Several animal models, including rats, rabbits, dogs, pigs, explored assess potential magnesium-based Moreover, strategies alloying coating identified enhance degradation transform opportunities. This review aims explore Mg across applications within (in vitro) vivo) models.

Language: Английский

---