Tissue and Cell, Journal Year: 2024, Volume and Issue: 91, P. 102611 - 102611
Published: Nov. 10, 2024
Language: Английский
Theranostics, Journal Year: 2024, Volume and Issue: 14(11), P. 4198 - 4217
Published: Jan. 1, 2024
The utilization of extracellular vesicles (EVs) in wound healing has been well-documented.However, the direct administration free EVs via subcutaneous injection at sites may result rapid dissipation bioactive components and diminished therapeutic efficacy.Functionalized hydrogels provide effective protection, as well ensure sustained release bioactivity during process, making them an ideal candidate material for delivering EVs.In this review, we introduce mechanisms by which accelerate healing, then elaborate on construction strategies engineered EVs.Subsequently, discuss synthesis application delivery systems to enhance complicated healing.Furthermore, face wounds, functionalized with specific microenvironment regulation capabilities, such antimicrobial, anti-inflammatory, immune regulation, used loading EVs, potential approaches addressing these challenges.Ultimately, deliberate future trajectories outlooks, offering a fresh viewpoint advancement artificial intelligence (AI)-energized materials 3D bio-printed multifunctional hydrogel-based dressings biomedical applications.
Language: Английский
Citations
14
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 836 - 836
Published: Jan. 20, 2025
Extracellular vesicles (EVs) are lipid bilayer particles released by virtually all cells, with prominent roles in both physiological and pathological processes. The size, number, molecular composition of EVs correlate to the cells origin, modulated cell’s environment pathologic state. proteins, DNA, RNA, protein cargo carried protected degradation, a role targeted intercellular signaling. These properties make salient targets as carriers biomarkers potential therapeutic delivery vehicles. majority EV research has focused on blood, urine, saliva, cerebrospinal fluid due easy accessibility. have also been identified studied ocular biofluids, including vitreous humor, aqueous tear film, study disease is new, promising, underexplored direction unique challenges considerations. This review covers recent advances diagnostic use EVs, focus human applications key preceding vitro vivo animal studies. We discuss future directions based other organ systems sates.
Language: Английский
Citations
0
Burns, Journal Year: 2025, Volume and Issue: 51(4), P. 107443 - 107443
Published: March 7, 2025
Language: Английский
Citations
0
Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
Language: Английский
Citations
0
Regenerative Biomaterials, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 1, 2025
Wound defects pose a substantial challenge in clinical practice, often resulting prolonged healing times and an elevated risk of infection. Insufficient vascularization is critical factor that adversely affects wound healing. Exosomes obtained from bone mesenchymal stem cells (BMSC-exos) have demonstrated significant promise accelerating tissue repair by promoting angiogenesis. However, their limited yield suboptimal biological functions impede widespread application enhancing Prior research has indicated 3D cultures can boost exosome secretion when compared to conventional 2D cultures. the currently prevalent culture methods necessitate expensive equipment or cumbersome procedures. This study investigates cost-effective user-friendly system developed using gelatin methacrylate (GelMA). Our findings indicate 5% concentration GelMA provides optimal environment for BMSCs. Furthermore, we observed significantly delays senescence BMSCs, thereby creating favorable conditions sustained production exosomes. Additionally, cultivation potential enhance angiogenic capabilities. In vivo experiments further confirmed BMSC-exos exhibit enhanced capabilities promote These results suggest GelMA-based offer novel strategy both industrial
Language: Английский
Citations
0
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 11213 - 11233
Published: Nov. 1, 2024
Abstract: Burn wounds pose intricate clinical challenges due to their severity and high risk of complications, demanding advanced therapeutic strategies beyond conventional treatments. This review discusses the application nanoparticle-based therapies for optimizing burn wound healing. We explore critical phases healing, including inflammation, proliferation, remodeling, while summarizing key that influence these processes optimize Various nanoparticles, such as metal-based, polymer-based, extracellular vesicles, are evaluated distinctive properties mechanisms action, antimicrobial, anti-inflammatory, regenerative effects. Future directions highlighted, focusing on personalized integration sophisticated drug delivery systems, emphasizing transformative potential nanoparticles in enhancing treatment. Keywords: nanomedicine, burns, wound, regeneration, therapy
Language: Английский
Citations
2
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 669, P. 125089 - 125089
Published: Dec. 16, 2024
Language: Английский
Citations
2
Tissue and Cell, Journal Year: 2024, Volume and Issue: 91, P. 102611 - 102611
Published: Nov. 10, 2024
Language: Английский
Citations
0