Mussel-inspired adhesive drug-loaded hydrogels for oral ulcers treatment

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 187, P. 98 - 109

Published: Aug. 28, 2024

Language: Английский

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Mechanism of Curcumin in the Treatment of Intrauterine Adhesions Based on Network Pharmacology, Molecular docking, and Experimental Validation

Biochemical Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Language: Английский

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Biomaterials for neuroengineering: Applications and challenges

Regenerative Biomaterials, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 1, 2025

Abstract Neurological injuries and diseases are a leading cause of disability worldwide, underscoring the urgent need for effective therapies. Neural regaining enhancement therapies seen as most promising strategies restoring neural function, offering hope individuals affected by these conditions. Despite their promise, path from animal research to clinical application is fraught with challenges. Neuroengineering, particularly through use biomaterials, has emerged key field that paving way innovative solutions It seeks understand treat neurological disorders, unravel nature consciousness, explore mechanisms memory brain’s relationship behavior, tissue engineering, interfaces targeted drug delivery systems. These including both natural synthetic types, designed replicate cellular environment brain, thereby facilitating repair. This review aims provide comprehensive overview biomaterials in neuroengineering, highlighting functional across basic practice. covers recent developments biomaterial-based products, 2D 3D bioprinted scaffolds cell organoid culture, brain-on-a-chip systems, biomimetic electrodes brain–computer interfaces. also explores artificial synapses networks, discussing applications modeling microenvironments repair regeneration, modulation manipulation integration traditional Chinese medicine. serves guide role advancing neuroengineering solutions, providing insights into ongoing efforts bridge gap between innovation application.

Language: Английский

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Current advances in understanding endometrial epithelial cell biology and therapeutic applications for intrauterine adhesion

Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 25, 2024

The human endometrium is a highly regenerative tissue capable of undergoing scarless repair during the menstruation and postpartum phases. This process mediated by endometrial adult stem/progenitor cells. During healing injuries, swift reepithelization results in rapid covering wound surface facilitates subsequent restoration. involvement endogenous epithelial stem cells, stromal bone marrow-derived cells regeneration epithelium has been subject prolonged debate. Increasing evidence suggests that mainly relies on rather than Currently, no consensus established identity compartment. Several markers, including stage-specific embryonic antigen-1 (SSEA-1), sex-determining region Y-box 9 (SOX9), neural-cadherin (N-cadherin), leucine-rich-repeat-containing G-protein-coupled receptor 5 (LGR5), CD44, axis inhibition protein 2 (Axin2), aldehyde dehydrogenase 1A1 (ALDH1A1), have suggested as potential candidate markers for identification contributes to our understanding offers new therapeutic insights into diseases characterized defects endometrium, such intrauterine adhesion. review explores different perspectives origins mouse It summarizes locations, hierarchies both endometrium. also discusses cell-based treatments adhesion, hoping inspire further research clinical application

Language: Английский

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Suture-Mediated Delivery System Reduces the Incidence of Uterine Scarring Through the TGF-β Pathway

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(2), P. 52 - 52

Published: Feb. 7, 2025

In recent years, factors such as the postponement of childbearing and relaxation policy have led to an increase in proportion cesarean sections other intrauterine surgeries among pregnant women, further increasing incidence uterine scars. Currently, there is a lack effective clinical treatment methods for this study, suture loaded with gene medicine was designed repair Specifically, non-viral vector Lipo8000 first used form complex solution plasmid TGF-β3. Then, it mixed adsorbed surgical sutures pretreated recombinant human type III collagen (RhCol III). vitro experiments confirmed that RhCol were successfully onto could be released expressed. vivo carried out using rat model simulating The section results showed compared scar group, expression level TGF-β3 III+TGF-β3 group increased by 39%, TGF-β1 decreased 62.8%, fibrosis rate 16.8%, which has positive effect on prevention This study integrates therapeutic into sutures, ensuring can come contact wound site after suturing. Moreover, work synergistically promote wounds.

Language: Английский

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Advances in synthetic strategies and applications of polymeric hydrogels

Polymer Engineering and Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract Hydrogels are three‐dimensional networks of hydrophilic polymers capable absorbing and retaining a significant amount water while maintaining their structural integrity. Their biocompatibility, tunable physical characteristics, resemblance to the extracellular matrix make them highly versatile in biomedical engineering. This paper provides comprehensive overview hydrogels, covering historical development, classification, synthetic fabrication strategies tailored for specific applications. widespread use spans biomedical, industrial, environmental fields, driven by high retention, responsiveness external stimuli. In biomedicine, hydrogels play crucial role drug delivery, wound healing, tissue engineering, biosensing, bioprinting, with applications extending cardiac regeneration neural growth. Additionally, they function as smart materials sensors actuators contribute advancements flexible electronics energy storage. Finally, current trends, challenges, opportunities hydrogel have been summarized. Highlights New (HG) elucidated. Enhanced biocompatibility boosts HG life sciences. haspotential uses field, controlled delivery release. Advanced HGs characteristics needed various

Language: Английский

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Rheological Characterization of Genipin-Based Crosslinking Pigment and O-Carboxymethyl Chitosan–Oxidized Hyaluronic Acid In Situ Formulable Hydrogels

Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2615 - 2615

Published: Sept. 15, 2024

The aim of this study was to develop a material capable rapidly absorbing bodily fluids and forming resilient, adhesive, viscoelastic hydrogel in situ prevent post-surgical adhesions. This formulated using O-carboxymethyl chitosan (O-CMCS), oxidized hyaluronic acid (OHA), crosslinking pigment derived from genipin glutamic (G/GluP). Both crosslinked (O-CMCS/OHA-G/GluP) non-crosslinked hydrogels (O-CMCS/OHA) were evaluated HAAKE™ MARS™ rheometer for their potential as barriers. A rheological analysis, including dynamic oscillatory measurements, revealed that the exhibited significantly higher elastic moduli (G′), indicating superior gel formation mechanical stability compared hydrogels. G/GluP crosslinker enhanced by increasing separation between G′ G″ achieving lower loss tangent (tan δ < 1.0), robustness under physiological conditions. rapid hydration gelation properties underscore effectiveness physical Furthermore, O-CMCS/OHA-G/GluP demonstrated self-healing efficient application via spraying or spreading, with tissue adherence viscoelasticity facilitate movement tissues organs, effectively preventing Additionally, proved be both cost effective scalable, highlighting its clinical applications aimed at

Language: Английский

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