Expanding the role of exosomes in drug, biomolecule, and nanoparticle delivery
Life Sciences,
Journal Year:
2025,
Volume and Issue:
368, P. 123499 - 123499
Published: Feb. 22, 2025
Language: Английский
Recent advances in pharmacological treatments of proliferative vitreoretinopathy
Current Opinion in Ophthalmology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Purpose
of
review
Proliferative
vitreoretinopathy
(PVR)
is
a
severe
complication
retinal
detachment
and
trauma,
posing
significant
challenges
to
surgical
success
visual
prognosis.
Despite
advancements
in
vitreoretinal
surgery,
PVR
incidence
remains
unchanged,
this
presents
synthesis
the
principal
clinical
preclinical
research
findings
from
recent
years.
Recent
has
focused
on
anti-inflammatory,
antiproliferative,
antifibrotic
agents.
Corticosteroids,
such
as
triamcinolone
dexamethasone,
show
promise
reducing
inflammation
but
have
inconsistent
results.
Methotrexate
mitomycin
C
demonstrate
efficacy
select
scenarios.
Anti-vascular
endothelial
growth
factor
agents
immunotherapies,
like
infliximab,
shown
limited
benefits
despite
promising
data.
Novel
approaches,
including
CB2
receptor
agonists,
exosome-based
drug
delivery,
nuclear
kappa
B
pathway
inhibitors,
are
gaining
traction.
Additionally,
RNA-based
multitargeted
therapies
highlight
importance
addressing
inflammation,
fibrosis,
proliferation
simultaneously.
Summary
Effective
management
requires
multifaceted
targeting
its
complex
pathogenesis.
While
current
treatments
limited,
ongoing
precision
delivery
combination
offers
hope
for
improved
outcomes.
Future
strategies
should
focus
translating
into
robust
applications.
Language: Английский
Engineered Cell Membrane Coating Technologies for Biomedical Applications: From Nanoscale to Macroscale
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 24, 2025
Cell
membrane
coating
has
emerged
as
a
promising
strategy
for
the
surface
modification
of
biomaterials
with
biological
membranes,
serving
cloak
that
can
carry
more
functions.
The
cloaked
inherit
diverse
intrinsic
biofunctions
derived
from
different
cell
sources,
including
enhanced
biocompatibility,
immunity
evasion,
specific
targeting
capacity,
and
immune
regulation
regenerative
microenvironment.
characteristics
biomimicry
biointerfacing
have
demonstrated
versatility
technology
on
variety
biomaterials,
thus,
furthering
research
into
wide
range
biomedical
applications
clinical
translation.
Here,
preparation
coatings
is
emphasized,
sizes
coated
nanoscale
to
macroscale
well
engineering
strategies
introduce
additional
are
summarized.
Subsequently,
utilization
biomimetic
membrane-cloaked
in
discussed,
drug
delivery,
imaging
phototherapy,
cancer
immunotherapy,
anti-infection
detoxification,
implant
modification.
In
conclusion,
latest
advancements
preclinical
studies,
along
multiple
benefits
membrane-coated
nanoparticles
(NPs)
systems,
elucidated.
Language: Английский