Update on the correlation between mitochondrial function and osteonecrosis of the femoral head osteocytes DOI Creative Commons
Chengming Li,

Hangyu Ji,

Suyang Zhuang

et al.

Redox Report, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 18, 2025

Mitochondrial health is maintained in a steady state through mitochondrial dynamics and autophagy processes. Recent studies have identified healthy mitochondria as crucial regulators of cellular function survival. This process involves adenosine triphosphate (ATP) synthesis by oxidative phosphorylation (OXPHOS), regulation calcium metabolism inflammatory responses, intracellular stress management. In the skeletal system, they participate behaviors responses osteoblasts, osteoclasts, chondrocytes, osteocytes to external stimuli. Indeed, damage or dysfunction occurs development few bone diseases. For example, may lead an imbalance osteoblasts resulting osteoporosis, osteomalacia, poor production, chondrocyte death infiltration osteoarthritis are main causes cartilage degeneration due damage. However, opposite exists for osteosarcoma, where overactive able accelerate proliferation migration osteosarcoma cells, which major disease feature. Bone dynamic organ play fundamental role all regions tissue involved regulating integrity. review examines impact physiological on osteocyte summarizes microscopic molecular mechanisms underlying its effects. It highlights that targeted therapies focusing be beneficial survival, providing new insight diagnosis, prevention, treatment diseases associated with death.

Language: Английский

Bibliometric mapping of mesenchymal stem cell therapy for bone regeneration from 2013 to 2023 DOI Creative Commons
Qianqian Chen, Yiqi Su, Zhen Yang

et al.

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 6, 2025

Mesenchymal stem cells (MSCs) have shown significant potential in bone regeneration and regenerative medicine recent years. With the advancement of tissue engineering, MSCs been increasingly applied repair regeneration, their clinical application has grown through interdisciplinary approaches involving biomaterials genetic engineering. However, there is a lack systematic reviews summarizing applications regeneration. To address this gap, we analyzed latest research on for published from 2013 to 2023. Using Web Science Core Collection, conducted literature search December 2024 employed bibliometric tools like CiteSpace VOSviewer comprehensive analysis key trends. Our findings focus development cell highlighting advantages, limitations, future prospects MSC These insights aim enhance understanding MSC-based inspire new directions, facilitate translation research.

Language: Английский

Citations

3
Development of an innovative cylindrical carbon nanofiber/gelatin-polycaprolactone hydrogel scaffold for enhanced bone regeneration DOI
Eman Serag, Ahmed Maher Eltawila,

Emad A. Salem

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141250 - 141250

Published: Feb. 1, 2025

Language: Английский

Citations

2
Update on the correlation between mitochondrial function and osteonecrosis of the femoral head osteocytes DOI Creative Commons
Chengming Li,

Hangyu Ji,

Suyang Zhuang

et al.

Redox Report, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 18, 2025

Mitochondrial health is maintained in a steady state through mitochondrial dynamics and autophagy processes. Recent studies have identified healthy mitochondria as crucial regulators of cellular function survival. This process involves adenosine triphosphate (ATP) synthesis by oxidative phosphorylation (OXPHOS), regulation calcium metabolism inflammatory responses, intracellular stress management. In the skeletal system, they participate behaviors responses osteoblasts, osteoclasts, chondrocytes, osteocytes to external stimuli. Indeed, damage or dysfunction occurs development few bone diseases. For example, may lead an imbalance osteoblasts resulting osteoporosis, osteomalacia, poor production, chondrocyte death infiltration osteoarthritis are main causes cartilage degeneration due damage. However, opposite exists for osteosarcoma, where overactive able accelerate proliferation migration osteosarcoma cells, which major disease feature. Bone dynamic organ play fundamental role all regions tissue involved regulating integrity. review examines impact physiological on osteocyte summarizes microscopic molecular mechanisms underlying its effects. It highlights that targeted therapies focusing be beneficial survival, providing new insight diagnosis, prevention, treatment diseases associated with death.

Language: Английский

Citations

0