ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(16)

Published: April 1, 2025

Abstract Tissue engineering aiming to develop and manufacture bioactive tissue or organ substitutes has been extensively studied. As an ideal scaffold material, the microsphere‐hydrogel combination system (MHCS), which combines excellent functionalities of hydrogels unique structural advantages microspheres, widely used in development biological for engineering. With adjustable mechanical properties, MHCS can simulate extracellular matrix‐like microstructure microenvironment conducive cell growth. These properties endow with repair, leading significant progress regeneration bone, skin, blood vessels, nerves, other tissues. In this paper, we reviewed latest construction based on natural polymers, synthetic inorganic materials, their composites. We also classified raw materials that were utilized microspheres discussed applications MHCS. Finally, challenges perspectives emphasized pointed out direction future development, such as conducted advanced processing technologies multidisciplinary cooperation solve limitations uneven microsphere distribution mismatched degradation rates, thus providing a reference design fabrication field

Language: Английский