Plant and animal-derived fusion nanovesicles rescue inflammation-compromised osteogenic potential of periodontal ligament stem cells DOI Creative Commons

Jingxiong Lin,

Manchun Li, Linglu Wang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 27, 2025

Periodontitis is a chronic inflammatory disease affecting the supporting tissues of teeth and has emerged as global public health issue. Current therapies primarily address pathogenic factors alleviate symptoms, with limited options available for complete restoration reconstruction already absorbed periodontal bone tissue. In this study, we developed nanotherapeutic strategy utilizing fusion nanovesicles (FVs) to modulate microenvironment create regenerative niche ligament stem cells (PDLSCs), which play crucial role in tissue repair. The FVs are composed Scutellaria baicalensis (SBNVs) anti-Porphyromonas gingivalis (P. gingivalis) anti-inflammatory properties, combined PDLSC membrane-derived genetically engineered express TNFR1. These preserved biological activity SBNVs immunomodulatory function PDLSCs. Additionally, effectively captured cleared TNF-α from through Moreover, alleviated response PDLSCs induced by P. gingivalis-LPS (Pg-LPS) TNF-α, restoring their proliferation, migration, osteogenic differentiation capabilities. Hence, holds great potential treating periodontitis.

Language: Английский

Plant and animal-derived fusion nanovesicles rescue inflammation-compromised osteogenic potential of periodontal ligament stem cells DOI Creative Commons

Jingxiong Lin,

Manchun Li, Linglu Wang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 27, 2025

Periodontitis is a chronic inflammatory disease affecting the supporting tissues of teeth and has emerged as global public health issue. Current therapies primarily address pathogenic factors alleviate symptoms, with limited options available for complete restoration reconstruction already absorbed periodontal bone tissue. In this study, we developed nanotherapeutic strategy utilizing fusion nanovesicles (FVs) to modulate microenvironment create regenerative niche ligament stem cells (PDLSCs), which play crucial role in tissue repair. The FVs are composed Scutellaria baicalensis (SBNVs) anti-Porphyromonas gingivalis (P. gingivalis) anti-inflammatory properties, combined PDLSC membrane-derived genetically engineered express TNFR1. These preserved biological activity SBNVs immunomodulatory function PDLSCs. Additionally, effectively captured cleared TNF-α from through Moreover, alleviated response PDLSCs induced by P. gingivalis-LPS (Pg-LPS) TNF-α, restoring their proliferation, migration, osteogenic differentiation capabilities. Hence, holds great potential treating periodontitis.

Language: Английский

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