Hierarchical Pathways from Sensory Processing to Cognitive, Clinical, and Functional Impairments in Schizophrenia

Schizophrenia Bulletin, Journal Year: 2020, Volume and Issue: 47(2), P. 373 - 385

Published: Aug. 3, 2020

Abstract Cognitive impairment is a hallmark of schizophrenia and robust predictor functional outcomes. Impairments are found in all phases the illness only moderately attenuated by currently approved therapeutics. Neurophysiological indices sensory discrimination (ie, mismatch negativity (MMN) P3a amplitudes) gamma-band auditory steady-state response (ASSR; power phase locking) translational biomarkers widely used development novel therapeutics for neuropsychiatric disorders. It unclear whether laboratory-based EEG measures add explanatory to well-established models that use cognitive, clinical, outcome measures. Moreover, it if ASSR uniquely contribute putative causal pathways linking discrimination, neurocognition, negative symptoms, outcomes schizophrenia. To answer these questions, hierarchical associations among processing, clinical were assessed via structural equation modeling large sample patients (n = 695) healthy comparison subjects 503). The results showed neurophysiologic both significantly yield unique hierarchical, “bottom-up” effects on functioning. Measures direct neurocognition while had effect patients. Continued investigation neural mechanisms underlying abnormal networks MMN/P3a needed clarify pathophysiology therapeutic interventions.

Language: Английский

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Predictive waves in the autism-schizophrenia continuum: A novel biobehavioral model

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 132, P. 1 - 22

Published: Nov. 11, 2021

Language: Английский

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Cortical Microcircuit Mechanisms of Mismatch Negativity and Its Underlying Subcomponents

Frontiers in Neural Circuits, Journal Year: 2020, Volume and Issue: 14

Published: March 31, 2020

In the neocortex, neuronal processing of sensory events is significantly influenced by context. For instance, responses in cortices are suppressed to repetitive or redundant stimuli, a phenomenon termed "stimulus-specific adaptation" (SSA). However, context which that same stimulus novel, deviates from expectations, augmented. This augmentation "deviance detection" (DD). contextual modulation neural fundamental for how brain efficiently processes world guide immediate and future behaviors. Notably, deficient some neuropsychiatric disorders such as schizophrenia (SZ), quantified reduced "mismatch negativity" (MMN), an electroencephalography waveform reflecting combination SSA DD cortex. Although role NMDA-receptor function other neuromodulatory systems on MMN established, precise microcircuit mechanisms its underlying components, DD, remain unknown. When coupled with animal models, development powerful precision neurotechnologies over past decade carries significant promise making new progress into understanding neurobiology previously unreachable spatial resolution. Currently, rodent models represent best tool mechanistic study due vast genetic tools available. While quantifying human-like waveforms rodents not straightforward, "oddball" paradigms used it humans subcomponents (SSA/DD) highly translatable across species. Here we summarize efforts published so far, focus cortically measured animals maintain relevance classically MMN, has cortical origins. studies measure contrast both components sparse, synthesize potential set existing rodent, primate, human literature. likely reflect several multiple regions, important step understand whole. We hypothesize reflects adaptations occurring at synapses along sensory-thalamocortical pathways, while depends inherited afferent inputs resulting disinhibition non-adapted neurons arising distinct physiology wiring properties local interneuronal subpopulations function.

Language: Английский

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A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia

Frontiers in Psychiatry, Journal Year: 2020, Volume and Issue: 11

Published: July 8, 2020

Mismatch negativity (MMN) is a widely used biological marker for schizophrenia research. Previous studies reported that MMN amplitude was reduced in and associated with cognitive impairments poor functional outcome schizophrenia. However, the neurobiological mechanisms underlying remain unclear. Recent suggest may reflect altered predictive coding In this paper, we reviewed new paradigms computational modeling to investigate Studies using roving oddball paradigm modified revealed effects of conditional probability were impaired omission many-standards prediction error, but not adaptation, A study local-global hierarchical structures at both local global levels Furthermore, dynamic causal neural networks These findings indicate underlies there are several unsolved questions about optimal procedures, association among paradigms, heterogeneity Future solve these questions, lead clarifying pathophysiology development individualized treatments

Language: Английский

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Unique contributions of sensory discrimination and gamma synchronization deficits to cognitive, clinical, and psychosocial functional impairments in schizophrenia

Schizophrenia Research, Journal Year: 2021, Volume and Issue: 228, P. 280 - 287

Published: Jan. 22, 2021

Language: Английский

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Change detection in the primate auditory cortex through feedback of prediction error signals

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Nov. 13, 2023

Although cortical feedback signals are essential for modulating feedforward processing, no error signal across hierarchical areas has been reported. Here, we observed such a in the auditory cortex of awake common marmoset during an oddball paradigm to induce duration mismatch negativity. Prediction errors deviant tone presentation were generated as offset calcium responses layer 2/3 neurons rostral parabelt (RPB) higher-order cortex, while non-deviant tones strongly suppressed. Within several hundred milliseconds, propagated broadly into 1 primary (A1) and accumulated locally on top incoming signals. Blockade RPB activity prevented deviance detection A1. Optogenetic activation following nonlinearly enhanced A1 response. Thus, is critical automatic unpredicted stimuli physiological processing may serve backpropagation-like learning.

Language: Английский

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Abnormal Effective Connectivity Underlying Auditory Mismatch Negativity Impairments in Schizophrenia

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2020, Volume and Issue: 5(11), P. 1028 - 1039

Published: June 5, 2020

Language: Английский

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Auditory Mismatch Negativity Under Predictive Coding Framework and Its Role in Psychotic Disorders

Frontiers in Psychiatry, Journal Year: 2020, Volume and Issue: 11

Published: Sept. 10, 2020

Traditional neuroscience sees sensory perception as a simple feedforward process. This view is challenged by the predictive coding model in recent years due to robust evidence researchers had found on how our prediction could influence perception. In first half of this article, we reviewed concept brain and some empirical visual auditory processing. The function along pathway was mainly studied mismatch negativity (MMN) – response an unexpected disruption regularity. We summarised range MMN paradigms discussed they contribute theoretical development neural network mechanism adaptation deviance detection. Such methodological conceptual evolution sharpen tool better understand structural functional abnormality for neuropsychiatric disorder such schizophrenia.

Language: Английский

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EEG, MEG and neuromodulatory approaches to explore cognition: Current status and future directions

Brain and Cognition, Journal Year: 2021, Volume and Issue: 148, P. 105677 - 105677

Published: Jan. 22, 2021

Neural oscillations and their association with brain states cognitive functions have been object of extensive investigation over the last decades. Several electroencephalography (EEG) magnetoencephalography (MEG) analysis approaches explored oscillatory properties identified, in parallel technical computational advancement. This review provides an up-to-date account how EEG/MEG contributed to understanding cognition. Methodological challenges, recent developments translational potential, along future research avenues, are discussed.

Language: Английский

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Longitudinal relationships between mismatch negativity, cognitive performance, and real-world functioning in early psychosis

Schizophrenia Research, Journal Year: 2021, Volume and Issue: 228, P. 385 - 393

Published: Feb. 1, 2021

Language: Английский

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