Schizophrenia Bulletin,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 22, 2024
Abstract
Objective
This
study
investigated
the
relationships
between
baseline
peptide
antigen-related
IgG
levels
and
8-week
antipsychotic
drug
(APD)
treatment
response
rates
one-year
outcomes,
as
well
changes
in
first-episode
schizophrenia
(FES)
patients.
Methods
Sixteen
IgGs
from
proteins
encoded
by
schizophrenia-related
genes
were
selected
on
basis
of
several
selection
criteria
a
2022
genome-wide
association
study.
Novel
measured
drug-naïve
FES
patients
at
(n
=
155)
plasma
samples
60
healthy
controls
(HCs).
At
follow-up,
57
completed
both
symptom
autoantibody
assessments.
Statistical
analyses
included
t
tests,
Pearson
correlation
analysis,
linear
regression
mixed-effects
models,
simple
slope
analysis.
Results
Anti-MOB4
anti-PDIA3
significantly
lower
compared
to
HCs
showed
negative
with
excitement
factor
scores.
Baseline
anti-EMB
associated
response,
whereas
anti-MAD1L1
correlated
outcomes
The
trajectory
anti-FURIN
IgG,
anti-MAPK3
anti-ACTR1B
was
related
remission.
Conclusion
revealed
that
had
autoimmune
abnormalities,
different
being
short-term
or
long-term
efficacy,
these
antibody
regulated
APDs.
BMC Psychiatry,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Oct. 16, 2024
Schizophrenia
(SCZ)
shares
high
clinical
relevance
with
the
immune
system,
and
potential
interactions
of
psychopharmacological
drugs
system
are
still
an
overlooked
area.
Here,
we
aimed
to
identify
whether
second-generation
antipsychotics
(SGA)
monotherapy
or
combined
therapy
SGA
other
psychiatric
medications
influence
routine
blood
immunity
biomarkers
patients
SCZ.
Brain Sciences,
Journal Year:
2024,
Volume and Issue:
14(7), P. 725 - 725
Published: July 19, 2024
Background.
The
majority
of
deaths
in
patients
with
schizophrenia
and
other
severe
mental
illnesses
(SMIs)
are
caused
by
natural
causes,
such
as
cardiovascular
diseases
(CVDs).
increased
risk
CVD
somatic
SMIs
cannot
be
fully
explained
the
contribution
traditional
factors,
behavioral
patients’
lifestyle
peculiarities,
influence
antipsychotics.
present
review
has
following
main
objectives:
(1)
to
aggregate
evidence
that
neurodevelopmental
disorders
basis
SMIs;
(2)
provide
a
studies
have
addressed
shared
genetic
architecture
SMI
disease;
(3)
propose
substantiate
consideration
independent
endophenotypes
SMIs,
which
will
make
it
possible
place
research
within
framework
concepts
“neurodevelopmental
continuum
gradient”
“endophenotype”.
Methods.
A
comprehensive
literature
search
was
performed
on
1
July
2024.
using
PubMed
Google
Scholar
databases
up
June
Results.
current
reveals
considerable
overlap
between
susceptibility
loci
for
CVDs.
We
observed
can
considered
distinct
physical
health-related
endophenotypes.
Conclusions.
In
this
narrative
review,
results
recent
CVDs
summarized.
Reframing
multisystem
disease
should
contribute
activation
new
SMIs.
BMC Psychiatry,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Nov. 15, 2024
Immune
dysregulation
has
been
identified
as
a
contributing
factor
in
the
pathophysiology
of
schizophrenia.
This
study
aimed
to
investigate
variations
specific
immune
regulators
and
their
correlation
with
psychopathology
cognitive
functions
male
patients
chronic
Employing
cross-sectional
design,
this
included
72
The
Positive
Negative
Syndrome
Scale
(PANSS)
Repeatable
Battery
for
Assessment
Neuropsychological
Status
were
utilized
assess
functions,
respectively.
Serum
levels
interleukin
(IL)-4,
IL-10,
IL-12p40,
IL-13,
monocyte
chemoattractant
protein-1
(MCP-1)
measured.
There
significantly
increased
IL-4,
MCP-1,
alongside
decreased
IL-10
compared
controls
(all
P
<
0.05).
IL-4
showed
significant
negative
association
PANSS
positive
symptoms
(beta=-0.222,
=
0.042).
After
controlling
antipsychotic
medication,
BMI,
smoking,
was
no
longer
(r=-0.232,
0.055).
Additionally,
correlations
(beta
0.297,
0.008),
IL-13
0.371,
0.001),
MCP-1
0.280,
0.013)
language
scores
observed.
Increased
(P
0.044,
OR
1.994),
0.019,
2.245),
well
interactions
0.043,
2.000)
positively
associated
risk
schizophrenia,
while
lower
0.003,
0.2.867)
also
linked
an
risk.
associations
between
markers
clinical
features
schizophrenia
males
underscored
potential
immune-mediated
mechanisms
underlying
