Plasma microRNAs Associate Positive, Negative, and Cognitive Symptoms with Inflammation in Schizophrenia DOI Open Access
Takuya Miyano,

Masakazu Hirouchi,

Naoki Yoshimura

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13522 - 13522

Published: Dec. 17, 2024

Schizophrenia is a complex and heterogenous psychiatric disorder characterized by positive, negative, cognitive symptoms. Our previous study identified three subgroups of schizophrenia patients based on plasma microRNA (miRNA) profiles. The present aims to (1) verify the reproducibility miRNA-based patient stratification (2) explore pathophysiological pathways linked symptoms using miRNAs. We measured levels 376 miRNAs in samples obtained their Positive Negative Syndrome Scale (PANSS) scores Brief Assessment Cognition (BACS) scores. miRNA profiles similar as study, suggesting potentially reproducible. multivariate analysis optimal combinations estimate PANSS positive negative subscales BACS composite Those consistently enriched ‘inflammation’ ‘NFκB1′ according set enrichment analysis. literature-based text mining survey confirmed that those were associated with IL-1β, IL-6, TNFα, exacerbated are high inflammation. In conclusion, potential biomarker identify reflecting conditions investigate symptom-related molecular mechanisms schizophrenia.

Language: Английский

Long non-coding RNAs in schizophrenia DOI

Seyyed Navid Mousavinejad,

Seyed Ali Hosseini,

Mahdi Mohammadpour

et al.

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: 574, P. 120340 - 120340

Published: April 29, 2025

Language: Английский

Citations

0
Assessment of the German Version of Brief Assessment of Cognition in Schizophrenia (BACS) DOI

Matin Mortazavi,

Joseph J Amon,

Iris Jäger

et al.

Schizophrenia Research Cognition, Journal Year: 2025, Volume and Issue: 41, P. 100364 - 100364

Published: May 1, 2025

Language: Английский

Citations

0
Interaction between serum inflammatory cytokines and brain-derived neurotrophic factor in cognitive function among first-episode schizophrenia patients DOI Open Access
Lijun Cui,

Lili Cai,

Wan-Qiu Na

et al.

World Journal of Psychiatry, Journal Year: 2024, Volume and Issue: 14(12), P. 1804 - 1814

Published: Nov. 27, 2024

BACKGROUND The pathogenesis of cognitive impairment in schizophrenia (SCZ) remains unclear. Accumulating studies showed that inflammatory-immune dysregulation and altered brain derived neurotrophic factor (BDNF) levels play a crucial role the psychopathology SCZ. However, their association with dysfunction first-episode SCZ patients has not been thoroughly investigated. AIM To explore interaction effects between function inflammatory cytokines BDNF METHODS current study is cross-sectional case-control investigation recruited 84 (SCZ group) 80 healthy controls (HCs at Huzhou Third Municipal Hospital August 2021 September 2023. ELISA was employed to measure serum interleukin (IL)-1β, IL-4, IL-6, IL-10, BDNF. Chinese brief test (C-BCT) positive negative syndrome scales were measured severity psychiatric symptoms. RESULTS Compared HC group, group exhibited elevated IL-1β IL-6 levels, decreased reduced C-BCT scores (all P < 0.001). In SCZ, negatively correlated (r = -0.324, 0.05). Information processing speed -0.315, 0.05) positively 0.290, 0.05); attention, working memory, comprehensive ability, executive Multiple regression analysis influenced dimensions (β -0.218 -0.327, all attention ability by -0.199 -0.261, ; 0.209, . CONCLUSION Our findings suggested interrelationships immune deficiency might underlie pathological mechanisms impairments patients.

Language: Английский

Citations

3
Plasma microRNAs Associate Positive, Negative, and Cognitive Symptoms with Inflammation in Schizophrenia DOI Open Access
Takuya Miyano,

Masakazu Hirouchi,

Naoki Yoshimura

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13522 - 13522

Published: Dec. 17, 2024

Schizophrenia is a complex and heterogenous psychiatric disorder characterized by positive, negative, cognitive symptoms. Our previous study identified three subgroups of schizophrenia patients based on plasma microRNA (miRNA) profiles. The present aims to (1) verify the reproducibility miRNA-based patient stratification (2) explore pathophysiological pathways linked symptoms using miRNAs. We measured levels 376 miRNAs in samples obtained their Positive Negative Syndrome Scale (PANSS) scores Brief Assessment Cognition (BACS) scores. miRNA profiles similar as study, suggesting potentially reproducible. multivariate analysis optimal combinations estimate PANSS positive negative subscales BACS composite Those consistently enriched ‘inflammation’ ‘NFκB1′ according set enrichment analysis. literature-based text mining survey confirmed that those were associated with IL-1β, IL-6, TNFα, exacerbated are high inflammation. In conclusion, potential biomarker identify reflecting conditions investigate symptom-related molecular mechanisms schizophrenia.

Language: Английский

Citations

0