Subcortical imaging-derived phenotypes are associated with the risk of Parkinson’s disease: A Mendelian Randomization Study
Abstract
Background
The
abnormalities
of
subcortical
structures,
such
as
putamen
and
caudate,
play
a
key
role
in
the
occurrence
Parkinson’s
disease
(PD);
however,
whether
how
imaging-derived
phenotypes
(IDPs)
structures
are
causally
associated
with
risk
PD
remain
poorly
understood.
Methods
causal
associations
between
IDPs
from
UK
biobank
were
evaluated
bidirectional
two-sample
Mendelian
randomization
(MR)
studies.
Results
Totally
five
found
to
be
PD.
Among
these
IDPs,
IDP
168
(Global
volume
gray
matter,
OR
=
1.38
[1.16,
1.63],
P
1.82
x
10−
4),
214
(Right
volume,
1.31
[1.15,
1.50],
7.71
5)
1441
(T2*
signal
right
1.21
[1.09,
1.35],
5.23
4)
increased
In
contrast,
1358
(Mean
intensity
0.72
[0.62,
0.85),
6.77
1344
left
0.76
[0.65,
0.88],
3.23
reduced
Conclusions
specific
imaging
features
caudate
altered
developing
PD,
thereby
providing
new
insights
into
development
novel
predictive
biomarkers
therapies
for
patients.
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 26, 2024
Language: Английский