Journal of Integrative Neuroscience, Journal Year: 2024, Volume and Issue: 23(8)

Published: Aug. 21, 2024

Background: Sleep patterns often shift as people age, a phenomenon frequently associated with the onset of neurodegenerative conditions. Additionally, distinct alterations occur in brain structure individuals grow older, particularly within hippocampus, region known for its role cognition and sleep regulation. Yet, how exactly do changes relate to specific subfields hippocampus is still unclear. Methods: We conducted study involving non-demented healthy adults from Aiginition Longitudinal Biomarker Investigation Of Neurodegeneration (ALBION) cohort. Participants underwent objective measurements using wrist Actiwatch WatchPAT devices. Further, all participants same Magnetic Resonance Imaging (MRI) protocol, including 3D high resolution T1-weighted sequence, on 3.0 Tesla MRI scanner an eight-channel head coil. The aimed examine relationship between objectively measured metrics morphology twenty-two hippocampal subregions. Results: In total, 75 63 mean years age were included study. Results indicated that higher frequency awakenings during was increased volume right presubiculum body (beta = 0.630, p False Discovery Rate (FDR) <0.036). Longer duration showed tendency be smaller volumes body, hinting at possible negative impact prolonged this region. Similar trends observed regarding apnea volume. Further analysis based stratification revealed younger participants, longer linked decreased while greater number correlated Among older frequencies larger various subfields. Conclusions: These findings shed light complex characteristics structure, highlighting potential age-related differences. provides valuable insights into disruptions may cognitive function cognitively adults. research warranted elucidate underlying mechanisms implications diseases.

Language: Английский