Directed physiological networks in the human prefrontal cortex at rest and post transcranial photobiomodulation DOI Creative Commons
Sadra Shahdadian, Xinlong Wang, Hanli Liu

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 6, 2023

Abstract Cerebral infra-slow oscillation (ISO) is a source of vasomotion in endogenic (E; 0.005–0.02 Hz), neurogenic (N; 0.02–0.04 and myogenic (M; 0.04–0.2 Hz) frequency bands. In this study, we quantified changes prefrontal concentrations oxygenated hemoglobin (Δ[HbO]) redox-state cytochrome c oxidase (Δ[CCO]) as hemodynamic metabolic activity metrics, electroencephalogram (EEG) powers electrophysiological activity, using concurrent measurements 2-channel broadband near-infrared spectroscopy EEG on the forehead 22 healthy participants at rest. After preprocessing, multi-modality signals were analyzed generalized partial directed coherence to construct unilateral neurophysiological networks among three metrics (with simplified symbols HbO, CCO, EEG) each E/N/M band. The links these represent neurovascular, neurometabolic, metabolicvascular coupling (NVC, NMC, MVC). results illustrate that demand for oxygen by neuronal metabolism (EEG CCO) drives supply (HbO) all bands resting cortex. Furthermore, investigate effect transcranial photobiomodulation (tPBM), performed sham-controlled study delivering an 800-nm laser beam left right cortex same participants. performing data processing statistical analysis, obtained novel important findings: tPBM delivered either side triggered alteration or reversal network couplings entities (i.e., frequency-specific powers) physiological E N bands, demonstrating during post-tPBM period, both drive PFC. Overall, revealed facilitates significant modulation directionality electrophysiological, metabolic, activities.

Language: Английский

Test-retest reliability of fNIRS in resting-state cortical activity and brain network assessment in stroke patients DOI Creative Commons
Gongcheng Xu, Congcong Huo, Jiahui Yin

et al.

Biomedical Optics Express, Journal Year: 2023, Volume and Issue: 14(8), P. 4217 - 4217

Published: July 7, 2023

Resting-state functional near infrared spectroscopy (fNIRS) scanning has attracted considerable attention in stroke rehabilitation research recent years. The aim of this study was to quantify the reliability fNIRS cortical activity intensity and brain network metrics among resting-state patients, comprehensively evaluate effects frequency selection, duration, analysis preprocessing strategies on test-retest reliability. Nineteen patients with underwent two resting sessions an interval 24 hours. haemoglobin signals were preprocessed by principal component analysis, common average reference haemodynamic modality separation (HMS) algorithm respectively. activity, connectivity level, local (degree, betweenness efficiency) global calculated at 25 scales × 16 time windows. each metric quantified intraclass correlation coefficient. results show that (1) high-frequency band higher ICC values than low-frequency band, is more reliable individual channel level when averaged within region channel, (2) above 4-minute scan are generally 0.5, efficiency reach high excellent levels after 4 min (0.5 < 0.9), moderate or even poor for degree (ICC 0.5), (3) HMS performs best improving values. indicate a duration minutes can lead most assessing function patients. It recommended use correction method HMS, reporting degree, single should be performed caution. This paper provides first comprehensive experimental design rehabilitation.

Language: Английский

Citations

13
Directed physiological networks in the human prefrontal cortex at rest and post transcranial photobiomodulation DOI Creative Commons
Sadra Shahdadian, Xinlong Wang, Hanli Liu

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 3, 2024

Cerebral infra-slow oscillation (ISO) is a source of vasomotion in endogenic (E; 0.005-0.02 Hz), neurogenic (N; 0.02-0.04 and myogenic (M; 0.04-0.2 Hz) frequency bands. In this study, we quantified changes prefrontal concentrations oxygenated hemoglobin (Δ[HbO]) redox-state cytochrome c oxidase (Δ[CCO]) as hemodynamic metabolic activity metrics, electroencephalogram (EEG) powers electrophysiological activity, using concurrent measurements 2-channel broadband near-infrared spectroscopy EEG on the forehead 22 healthy participants at rest. After preprocessing, multi-modality signals were analyzed generalized partial directed coherence to construct unilateral neurophysiological networks among three metrics (with simplified symbols HbO, CCO, EEG) each E/N/M band. The links these represent neurovascular, neurometabolic, metabolicvascular coupling (NVC, NMC, MVC). results illustrate that demand for oxygen by neuronal metabolism (EEG CCO) drives supply (HbO) all bands resting cortex. Furthermore, investigate effect transcranial photobiomodulation (tPBM), performed sham-controlled study delivering an 800-nm laser beam left right cortex same participants. performing data processing statistical analysis, obtained novel important findings: tPBM delivered either side triggered alteration or reversal network couplings entities (i.e., frequency-specific powers) physiological E N bands, demonstrating during post-tPBM period, both drive (PFC). Overall, revealed facilitates significant modulation directionality electrophysiological, metabolic, activities.

Language: Английский

Citations

4
Quantification and stimulation of human glymphatic dynamics:New features of Alzheimer’s disease and effects of brain photobiomodulation DOI Creative Commons

Fiza Saeed,

Kathy L. Siepker,

Soeun Jang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

A non-invasive device to measure the dynamics of cerebrospinal fluid (CSF) is highly desirable because CSF facilitates cleaning neurotoxic wastes in brain. better understanding helps promote healthy aging older adults and treat patients with neurological diseases. This study employed a multi-color optical method quantify prefrontal two groups: (1) (n = 16) without 27) Alzheimer's disease (2) young 26) before after light stimulation. The results revealed that coupling strengths between cerebral blood volume (CBV) were age-dependent significantly higher AD than controls. Prefrontal stimulation enhanced CBV-CSF coupling, suggesting improved drainage. underscores strategy as unique tool for monitoring interaction CBV CSF, well metabolic functions human brain, while demonstrating therapeutic potential brain treating neurodegenerative diseases involving drainage dysfunction.

Language: Английский

Citations

0
Neuromodulation of brain power topography and network topology by prefrontal transcranial photobiomodulation DOI Creative Commons
Sadra Shahdadian, Xinlong Wang, Hashini Wanniarachchi

et al.

Journal of Neural Engineering, Journal Year: 2022, Volume and Issue: 19(6), P. 066013 - 066013

Published: Nov. 1, 2022

Objective.Transcranial photobiomodulation (tPBM) has shown promising benefits, including cognitive improvement, in healthy humans and patients with Alzheimer's disease. In this study, we aimed to identify key cortical regions that present significant changes caused by tPBM the electroencephalogram (EEG) oscillation powers functional connectivity human brain.Approach. A 64-channel EEG was recorded from 45 participants during a 13 min period consisting of 2 baseline, 8 tPBM/sham intervention, 3 recovery. After pre-processing normalizing data at five rhythms, cluster-based permutation tests were performed for multiple comparisons spectral power topographies, followed graph-theory analysis as topological approach quantification brain metrics global nodal/cluster levels.Main results. enhancement observed clusters channels over frontoparietal alpha band centroparietal beta band. The measures network revealed reduction synchronization, efficiency, small-worldness connectivity, implying an complexity. addition, band, nodal graphical demonstrated increases local information integration centrality frontal clusters, accompanied decrease segregation bilateral frontal, left parietal, occipital regions.Significance.Frontal increased frontal-central-parietal regions, enhanced complexity beta-wave network, augmented flow oscillations across prefrontal regions. This study sheds light on potential link between electrophysiological effects improvement induced tPBM.

Language: Английский

Citations

15
Site-specific effects of 800- and 850-nm forehead transcranial photobiomodulation on prefrontal bilateral connectivity and unilateral coupling in young adults DOI Creative Commons
Sadra Shahdadian, Xinlong Wang,

Shu Kang

et al.

Neurophotonics, Journal Year: 2023, Volume and Issue: 10(02)

Published: June 5, 2023

Transcranial photobiomodulation (tPBM) is a noninvasive neuromodulation method that facilitates the improvement of human cognition. However, limited information available in literature on wavelength- and site-specific effects prefrontal tPBM. Moreover, 2-channel broadband near-infrared spectroscopy (2-bbNIRS) new approach for quantifying infra-slow oscillations (ISO; 0.005 to 0.2 Hz) neurophysiological networks resting brain vivo.We aim prove hypothesis hemodynamic metabolic activities cortex are significantly modulated by tPBM modulation different ISO bands.Noninvasive 8-min with an 800- or 850-nm laser sham was delivered either side forehead 26 healthy young adults. A 2-bbNIRS unit used record activity 7 min before after tPBM/sham. The measured time series were analyzed frequency domain determine coherence at each three bands. Sham-controlled values represent tPBM-induced networks.Prefrontal wavelength lateral (1) increased ipsilateral metabolic-hemodynamic coupling endogenic band (2) desynchronized bilateral metabolism neurogenic vascular smooth-muscle hemodynamics myogenic band. Site-specific also observed significant enhancement connectivity right 800-nm tPBM.Prefrontal can modulate bilaterally unilaterally cortex. Such site- wavelength-specific

Language: Английский

Citations

7
Review of measurements and imaging of cytochrome-c-oxidase in humans using near-infrared spectroscopy: an update DOI Creative Commons

Georgina Leadley,

Topun Austin, Gemma Bale

et al.

Biomedical Optics Express, Journal Year: 2023, Volume and Issue: 15(1), P. 162 - 162

Published: Dec. 11, 2023

This review examines advancements in the measurement and imaging of oxidized cytochrome-c-oxidase (oxCCO) using near-infrared spectroscopy (NIRS) humans since 2016. A total 34 published papers were identified, with a focus on both adult neonate populations. The NIRS-derived oxCCO signal has been demonstrated to correlate physiological parameters hemodynamics. New instrumentation, such as systems that allow changes diffuse optical tomography or combine correlation measures blood flow, have advanced field past decade. However, variability its response across different populations paradigms lack standardization limit potential reliable valuable indicator brain health. Future studies should address these issues fulfill vision clinical biomarker.

Language: Английский

Citations

7
Unilateral Mitochondrial–Hemodynamic Coupling and Bilateral Connectivity in the Prefrontal Cortices of Young and Older Healthy Adults DOI Creative Commons

Claire Sissons,

Fiza Saeed,

Caroline Carter

et al.

Bioengineering, Journal Year: 2023, Volume and Issue: 10(11), P. 1336 - 1336

Published: Nov. 20, 2023

A recent study demonstrated that noninvasive measurements of cortical hemodynamics and metabolism in the resting human prefrontal cortex can facilitate quantitative metrics unilateral mitochondrial–hemodynamic coupling bilateral connectivity infraslow oscillation frequencies young adults. The includes three distinct vasomotions with endogenic (E), neurogenic (N), myogenic (M) frequency bands. goal this was to prove hypothesis there are significant differences between older adults (uCOP) (bCON) cortex. Accordingly, we performed from 24 (67.2 ± 5.9 years age) using same two-channel broadband near-infrared spectroscopy (bbNIRS) setup resting-state experimental protocol as those study. After quantification uCOP bCON E/N/M statistical analysis, had significantly weaker hemodynamic but stronger metabolic than M band. Furthermore, exhibited on both sides all bands, particularly a very large effect size band (>1.9). These age-related results clearly support our were well interpreted following neurophysiological principles. key finding paper is highly associated age may have potential become meaningful features for brain health be translatable future clinical applications, such early detection Alzheimer’s disease.

Language: Английский

Citations

2
Brain Activation Pattern Caused by Soft Rehabilitation Glove and Virtual Reality Scenes: A Pilot fNIRS Study DOI Creative Commons
Pengju Liu, Xinyi Yang,

Fenglin Han

et al.

IEEE Transactions on Neural Systems and Rehabilitation Engineering, Journal Year: 2024, Volume and Issue: 32, P. 3848 - 3857

Published: Jan. 1, 2024

Clinical studies have proved significant improvements in hand motor function stroke patients when assisted by robotic devices. However, there were few on neural activity changes the brain during execution. This study aimed to investigate activation pattern caused soft rehabilitation glove and virtual reality scenes. Twenty healthy subjects twenty recruited complete three controlled trials: grasping passively with assistance (RA), watching movement video (VR), joint use of (VRA). Neural prefrontal cortex, cortex occipital lobe was synchronously collected functional near-infrared spectroscopy (fNIRS) device. Activation level connectivity these regions subsequently calculated statistically analyzed. For both groups, VR VRA tasks induced larger cortical areas. Stroke group had higher average all compared group, especially ( [Formula: see text]). Functional weaker than across most regions, but significantly stronger some right hemisphere. These findings suggest differences patterns tasks. In addition, multi-sensory stimulation can promote communication between more patients. It has potential for neuromodulation training setting up different sensory modalities.

Language: Английский

Citations

0
Understanding metabolic responses to forearm arterial occlusion measured with two-channel broadband near-infrared spectroscopy DOI Creative Commons

Fiza Saeed,

Caroline Carter,

John O. Kolade

et al.

Journal of Biomedical Optics, Journal Year: 2024, Volume and Issue: 29(11)

Published: Nov. 29, 2024

SignificanceBroadband near-infrared spectroscopy (bbNIRS) is useful for the quantification of cerebral metabolism. However, its usefulness has not been explored broad biomedical applications.AimWe aimed to quantify dynamic responses oxidized cytochrome c oxidase (Δ[oxCCO]) within mitochondria arterial occlusion and correlations between hemodynamic (Δ[HbO]) Δ[oxCCO] during after in forearm tissues.ApproachWe recruited 14 healthy participants with two-channel bbNIRS measurements response a 5-min occlusion. The system consisted one shared white-light source two spectrometers. modified Beer-Lambert law was applied determine occlusion-induced changes Δ[HbO] shallow- deep-tissue layers.ResultsDuring occlusion, hemodynamics exhibited expected changes, but remained constant, as observed 1- 3-cm channels. A linear correlation only recovery phase, stronger deeper tissues. observation constant cuff period consistent previous reports. interpretation this based on literature that oxygen metabolism skeletal muscle remains unchanged before all oxy-hemoglobin (and oxy-myoglobin) resources are completely depleted. Because adequate exhaust supply vascular bed forearm, local maintains redox uninterrupted by occlusion.ConclusionsWe provide better understanding mitochondrial demonstrate bbNIRS.

Language: Английский

Citations

0
Unilateral Mitochondrial-Hemodynamic Coupling and Bilateral Connectivity in the Younger and Older Prefrontal Cortex of Healthy Adults DOI Open Access

Claire Sissons,

Fiza Saeed,

Caroline Carter

et al.

Published: Aug. 29, 2023

A recent study demonstrated that noninvasive measurements of cortical hemodynamics and metabolism in the resting human prefrontal cortex can facilitate quantitative metrics unilateral mitochondrial-hemodynamic coupling bilateral connectivity infraslow oscillation (ISO) frequencies young adults (YA). The ISO includes three distinct vasomotions with endogenic (E), neurogenic (N), myogenic (M) frequency bands. goal this was to prove hypothesis there are significant differences between older (OA) (uCOP) (bCON) cortex. Accordingly, we performed from 24 OA (67.2 ± 5.9 years age) using same 2-channel broadband near-infrared spectroscopy (bbNIRS) setup resting-state experimental protocol as those (Shahdadian et al, Cerebral Cortex Communications, 2022). After quantification uCOP bCON E/N/M statistical analysis, had significantly weaker hemodynamic but stronger metabolic than YA M band. Furthermore, exhibited on both sides all bands, particularly a very large effect size band (&amp;gt; 1.9). These age-related results clearly support our were well interpreted following neurophysiological principles. key finding paper is highly associated age may have potential become meaningful features for brain health be translatable future clinical applications, such early detection Alzheimer’s disease.

Language: Английский

Citations

1