Environmental Pollution,
Journal Year:
2024,
Volume and Issue:
unknown, P. 125595 - 125595
Published: Dec. 1, 2024
PER:
and
polyfluoroalkyl
substances
(PFAS)
are
a
large
group
of
synthetic
organic
chemicals
that
ubiquitous
environmental
pollutants.
Among
PFAS,
perfluorodecanoic
acid
(PFDA)
is
one
the
most
toxic
compounds,
but
molecular
basis
behind
its
toxicity
not
fully
understood.
In
an
interspecies
comparison
with
placental
cells
(HTR-8/SVneo)
zebrafish
embryos,
we
demonstrate
PFDA
induces
mitochondrial
dysfunction
impairs
fatty
β-oxidation.
Reduced
β-oxidation
leads
to
less
TCA
cycle
activity,
resulting
in
NADH
consequently
NADPH
production.
Thereby
NADPH-dependent
glutathione
recycling
impaired,
increasing
cellular
oxidative
stress
can
only
be
partially
compensated
by
NRF2
activation.
Frontiers in Toxicology,
Journal Year:
2024,
Volume and Issue:
6
Published: July 22, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
a
widespread
persistent
class
of
contaminants
posing
significant
environmental
human
health
concerns.
Comprehensive
understanding
the
modes
action
underlying
toxicity
among
structurally
diverse
PFAS
is
mostly
lacking.
To
address
this
need,
we
recently
reported
on
our
application
developing
zebrafish
to
evaluate
large
library
for
developmental
toxicity.
In
present
study,
prioritized
15
bioactive
that
induced
morphological
effects
performed
RNA-sequencing
characterize
early
transcriptional
responses
at
single
timepoint
(48
h
post
fertilization)
after
exposures
(8
fertilization).
Internal
concentrations
5
were
measured
from
pooled
whole
fish
samples
across
multiple
timepoints
between
24–120
fertilization,
additional
temporal
transcriptomics
several
(48–96
conducted
Nafion
byproduct
2.
A
broad
range
differentially
expressed
gene
counts
identified
exposures.
Most
elicited
robust
transcriptomic
changes
affected
biological
processes
brain
nervous
system
development.
While
disrupted
unique
processes,
also
found
similarities
in
some
functional
head
groups
associated
with
disruption
expression
similar
sets.
Body
burdens
select
sulfonic
acid
PFAS,
including
2,
increased
24–96
fertilization
sampling
greater
than
those
sulfonamide
chain
lengths.
parallel,
2-induced
48
96
fertilization.
characteristics
based
toxicity,
effects,
will
contribute
further
prioritization
structures
testing
informed
hazard
assessment.
Environmental Science & Technology,
Journal Year:
2023,
Volume and Issue:
57(40), P. 15173 - 15183
Published: Sept. 27, 2023
Partitioning
of
per-
and
polyfluoroalkyl
substances
(PFAS)
to
indoor
materials,
including
clothing,
may
prolong
the
residence
time
PFAS
indoors
contribute
exposure.
During
Indoor
Assessment
(IPA)
Campaign,
we
measured
concentrations
nine
neutral
in
air
cotton
cloth
11
homes
North
Carolina,
for
up
9
months.
Fluorotelomer
alcohols
(i.e.,
6:2
FTOH,
8:2
10:2
FTOH)
are
dominant
target
species
air,
with
ranging
from
1.8
49
ng
m–3,
1.2
53
0.21
5.7
respectively.
In
cloth,
perfluorooctane
sulfonamidoethanols
MeFOSE
EtFOSE)
accumulated
most
significantly
over
time,
reaching
0.26
cm–2
0.24
cm–2,
From
paired
measurements
suspended
derived
cloth–air
partition
coefficients
(Kca)
6:2,
8:2,
FTOH;
ethylperfluorooctane
sulfonamide
(EtFOSA);
MeFOSE;
EtFOSE.
Mean
log(Kca)
values
range
4.7
6.6
positively
correlated
octanol–air
coefficient.
We
investigated
effect
storage
method
on
accumulation
influence
home
characteristics
concentrations.
Temperature
had
overall
greatest
effect.
This
study
provides
valuable
insights
into
distribution,
fate,
exposure
indoors.
Journal of Mass Spectrometry,
Journal Year:
2025,
Volume and Issue:
60(2)
Published: Jan. 14, 2025
Perfluoroalkyl
and
polyfluoroalkyl
substances
(PFAS)
are
a
class
of
emerging
contaminants
that
have
been
in
use
industrially
since
the
1940s.
Their
long-term
extensive
commercial
has
led
to
their
ubiquitous
presence
environment.
The
ability
measure
bioconcentration
distribution
PFAS
tissue
aquatic
organisms
helps
elucidate
persistence
as
well
environmental
impacts.
Traditional
analysis
by
LC-MS/MS
can
total
concentrations
within
an
organism
but
cannot
provide
comprehensive
spatial
information
regarding
organism.
In
current
study,
we
used
infrared
matrix-assisted
laser
desorption
electrospray
ionization
(IR-MALDESI)
determine
limit
detection
(LOD)
several
utilizing
standard
mix
spotted
on
mouse
liver
tissue.
traditional
ice
matrix
alternative
matrix,
1,8-bis
(tetramethylguanidino)naphthalene
(TMGN),
were
explored
when
determining
limits
for
various
IR-MALDESI.
alone
resulted
higher
response
than
combination
TMGN
ice.
resulting
LOD
perfluorooctane
sulfonic
acid
(PFOS)
per
voxel
basis
was
0.16
fmol/voxel.
For
comparison,
zebrafish
exposed
perfluorooctanoic
(PFOA),
PFOS,
perfluorohexanesulfonic
(PFHxS)
at
different
homogenized,
extracted
solid-liquid
extraction,
purified
solid
phase
analyzed
level
bioaccumulation
zebrafish.
PFOS
highest
(731.9
μg/kg,
or
234.2
fg/voxel).
A
had
mixture
PFOA
(250
ng/L),
PFHxS
(125
ng/L)
cryosectioned
Images
could
not
be
generated
accumulation
sectioned
below
technique.
Heliyon,
Journal Year:
2025,
Volume and Issue:
11(4), P. e42782 - e42782
Published: Feb. 1, 2025
Per-
and
Poly-fluoroalkyl
substances
(PFASs)
are
among
the
that
have
been
widely
employed
across
world
due
to
their
distinct
features.
These
chemicals'
great
stability
in
environment
capacity
be
released
from
consumer
goods
demonstrated
existence
all
matrices.
Additionally,
world's
attention
has
drawn
these
substances'
direct
relation
human
health
recent
years.
This
research
aimed
unravel
nexus
of
PFASs
with
obesity
endocrine
disruption
as
a
comprehensive
review.
Studies
shown
drinking
water
is
primary
way
which
humans
exposed
PFASs.
As
result,
it
become
difficult
determine
how
contaminated
compounds
impacts
affect
health.
Through
various
routes,
metabolic
processes,
possible
effects
on
hypothalamus-pituitary-thyroid
axis,
chemicals
increase
incidence
obesity,
particularly
during
crucial
growth
phases.
Another
negative
impact
glands'
function,
for
controlling
body's
physiological
functions.
leads
alterations
hormone
production.
The
exposure
include
secondary
hyperparathyroidism,
non-alcoholic
fatty
liver,
diabetes,
cardiovascular
illnesses,
reproductive
abnormalities,
infertility.
Because
characteristics,
including
propensity
propagate
through
food
chain,
accumulate
biomagnify,
ultimately
pose
threat
life,
replace
remove
chemicals.
