Environmental Pollution,
Journal Year:
2024,
Volume and Issue:
unknown, P. 125595 - 125595
Published: Dec. 1, 2024
PER:
and
polyfluoroalkyl
substances
(PFAS)
are
a
large
group
of
synthetic
organic
chemicals
that
ubiquitous
environmental
pollutants.
Among
PFAS,
perfluorodecanoic
acid
(PFDA)
is
one
the
most
toxic
compounds,
but
molecular
basis
behind
its
toxicity
not
fully
understood.
In
an
interspecies
comparison
with
placental
cells
(HTR-8/SVneo)
zebrafish
embryos,
we
demonstrate
PFDA
induces
mitochondrial
dysfunction
impairs
fatty
β-oxidation.
Reduced
β-oxidation
leads
to
less
TCA
cycle
activity,
resulting
in
NADH
consequently
NADPH
production.
Thereby
NADPH-dependent
glutathione
recycling
impaired,
increasing
cellular
oxidative
stress
can
only
be
partially
compensated
by
NRF2
activation.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 4261 - 4261
Published: April 30, 2025
Perfluorooctanoic
acid
(PFOA)
is
a
persistent
environmental
contaminant
that
resists
biological
degradation
and
accumulates
in
organisms.
It
disrupts
zebrafish
embryo
development,
affecting
their
heartbeat
rate
locomotion.
Meanwhile,
probiotics
are
known
to
enhance
the
development
ossification
of
embryos.
In
this
study,
we
examined
toxic
effects
PFOA
on
growth
bone
formation
potential
probiotic
Bacillus
subtilis
var.
natto
counteract
its
toxicity.
Larvae
were
exposed
0,
50,
or
100
mg/L
from
hatching
21
days
post-fertilization
(dpf),
with
without
dietary
supplementation
(107
CFU/larva/day),
they
sampled
at
7,
14,
dpf.
exposure
reduced
standard
length
dpf,
while
co-administration
mitigated
these
effects.
Craniofacial
cartilage
defects
appeared
larvae
50
7
14
impaired
Probiotics
counteracted
abnormalities.
also
delayed
ossification,
correlating
downregulation
col10a1a,
runx2b,
cyp26b1,
treatment
restored
normal
ossification.
These
findings
improve
our
understanding
PFOA’s
detrimental
demonstrating
protective
role
against
PFOA-induced
developmental
Journal of Immunotoxicology,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: May 7, 2024
Per-
and
polyfluoroalkyl
substances
(PFASs)
are
a
large
class
of
compounds
used
in
variety
processes
consumer
products.
Their
unique
chemical
properties
make
them
ubiquitous
persistent
environmental
contaminants
while
also
making
economically
viable
socially
convenient.
To
date,
several
reviews
have
been
published
to
synthesize
information
regarding
the
immunotoxic
effects
PFASs
on
adaptive
immune
system.
However,
these
often
do
not
include
data
impact
innate
immunity.
Here,
current
literature
is
reviewed
identify
incorporate
immunity
humans,
experimental
models,
wildlife.
Known
mechanisms
by
which
modulate
function
reviewed,
including
disruption
cell
signaling,
metabolism,
tissue-level
effects.
For
where
available,
results
equivocal,
raising
additional
questions
about
common
or
pathways
toxicity,
but
highlighting
that
system
within
species
can
be
perturbed
exposure
PFASs.
Recommendations
provided
for
future
research
inform
hazard
identification,
risk
assessment,
management
practices
protect
systems
exposed
organisms
as
well
health.
Environmental Health Perspectives,
Journal Year:
2024,
Volume and Issue:
132(9)
Published: Sept. 1, 2024
Significant
progress
has
been
made
over
the
past
decade
in
measuring
chemical
components
of
exposome,
providing
transformative
population-scale
frameworks
probing
etiologic
link
between
environmental
factors
and
disease
phenotypes.
While
analytical
technologies
continue
to
evolve
with
reams
data
being
generated,
there
is
an
opportunity
complement
exposome-wide
association
studies
(ExWAS)
functional
analyses
advance
search
at
organismal,
cellular,
molecular
levels.
In
this
study,
we
compared
a
wide
range
of
cell-based
bioassays
to
the
use
chemical
analysis
followed
by
exposure-activity
ratio
(EAR)
and
Toxicological
Prioritization
index
(ToxPi)
for
prioritizing
chemicals,
sites,
hazard
concerns
in
water
samples.
Surface
samples
were
collected
from
nine
sites
three
Central
Pennsylvania
streams
analyzed
targeted
list
compounds
emerging
concern
(CECs),
including
pesticides,
personal
care
products,
pharmaceuticals.
Cell-based
reporter
assays
evaluated
human
zebrafish
molecular
initiating
events
(MIEs)
endocrine
metabolic
disruption,
altered
lipid
metabolism,
oxidative
stress.
Bioassays
showed
that
29
out
40
had
at
least
one
site
with
activity
over
limit
detection.
The
receptors
exhibited
highest
number
above
effect-based
trigger
(EBT)
values
would
be
expected
cause
toxicity
Aryl
hydrocarbon
receptor
(AhR,
zebrafish),
Pregnane
X
Receptor
(PXR),
Estrogen
Receptor-beta
(ERB),
Androgen
(AR).
Characterizing
collection
their
bioactivity
aligned
closely
stream
which
collected,
Warriors
Mark
Run,
Halfmoon,
Spruce
Run
more
similar
than
other
streams.
sum
all
EARs
each
indicated
pharmaceutical
Carbamazepine
pesticides
Carbaryl
Atrazine
posed
greatest
concern.
However,
predicted
prioritization
based
on
individual
calculated
EAR
different
those
measured
bioassay,
indicating
biologically
active
chemicals
are
present
not
included
analytes.
Taken
together,
these
data
show
beneficial
whereas
mechanism-based
inclusive
known
as
well
unknown
contaminants
thus
overall
quality
prioritization.
Toxics,
Journal Year:
2024,
Volume and Issue:
12(5), P. 369 - 369
Published: May 17, 2024
Perfluorooctanoic
acid
(PFOA)
is
a
globally
prevalent
contaminant
of
concern
recognised
for
its
persistence
and
detrimental
effects
on
both
wildlife
humans.
While
PFOA
has
been
established
as
disruptor
thyroid
function,
limited
data
exist
regarding
impact
morphology.
The
kidney
the
common
carp
(Cyprinus
carpio)
harbours
numerous
follicles,
rendering
it
valuable
biomarker
organ
investigating
PFOA-induced
alterations.
Renal
tissue
slides,
stained
with
Alcian
blue/PAS
method,
were
examined
from
in
three
experimental
groups:
unexposed,
exposed
to
200
ng
L−1,
2
mg
L−1
over
56
days.
Thyroid
follicle
colloids
segmented,
related
morphometric
parameters,
including
perimeter,
area,
shape
descriptors,
obtained.
Statistical
analyses
revealed
significant
reductions
colloid
perimeter
area
group
compared
unexposed
groups.
Additionally,
fish
exhibited
significantly
higher
count
fish.
These
findings
collectively
suggest
that
induces
folliculogenesis,
emphasising
morphology
even
at
an
environmentally
relevant
concentration
(200
L−1).
