Bibliometric Analysis of Per- and Polyfluoroalkyl Substances (PFASs) from 2000 to 2023 Based on Web of Science Database DOI Open Access

Zixuan Yin,

Li Cui, Xingyang Li

et al.

Water, Journal Year: 2024, Volume and Issue: 17(1), P. 6 - 6

Published: Dec. 24, 2024

Perfluorinated and polyfluoroalkyl substances (PFASs) have been extensively used in many fields since the 1950s due to their distinctive chemical stability. PFASs are becoming emerging pollutants, they attracted special attention all over world because of environmental persistence, bioaccumulation, potential toxicity. Through bibliometric analysis, this study provides a visual analysis 6055 articles about Web Science database from 2000 2023. Research on can be divided into two stages, 2000–2014 2015–2023, number publications frequency citations increase rapidly latter stage. Studies highly interdisciplinary, mainly focusing cluster ecological environmental, involving science, engineering, toxicology. The authors come 106 countries, with United States China being most productive contributors. However, has relatively low per article. A total 2634 institutions participated studies, USA outstanding. An author cooperation shows that lead publication output research activity. Some Chinese rank among top contributors, but there is need for stronger international cooperation. Keyword clusters burst reveal key areas PFASs, including classification, behavior, health effects, removal methods. This comprehensive perspective offering valuable insights trends serving as critical reference future research, policy development, technological innovation.

Language: Английский

Innovative techniques for combating a common enemy forever chemicals: A comprehensive approach to mitigating per- and polyfluoroalkyl substances (PFAS) contamination DOI
Ajibola A. Bayode, Stephen Sunday Emmanuel, Amos Olalekan Akinyemi

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 261, P. 119719 - 119719

Published: Aug. 3, 2024

Language: Английский

Citations

7
Broad PFAS binding with fatty acid binding protein 4 is enabled by variable binding modes. DOI Creative Commons
Aaron S. Birchfield, Faik N. Musayev,

Abdul J. Castillo

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Per- and polyfluoroalkyl substances (PFAS) are ubiquitous pollutants that bioaccumulate in wildlife humans, yet the molecular basis of their protein interactions remains poorly understood. Here, we show human adipocyte fatty acid-binding (FABP4) can bind a diverse array PFAS, including next-generation replacements for legacy chemicals longer-chain perfluorocarboxylic acids. Shorter-chain although weaker binders, still displayed measurable affinities—surpassing those nonfluorinated analogs. We determined crystal structures FABP4 bound to perfluorooctanoic acid (PFOA), perfluorodecanoic (PFDA), perfluorohexadecanoic (PFHxDA), revealing three distinct binding modes. Notably, PFOA binds two separate sites, conformations define single-ligand PFDA PFHxDA. These arrangements enhance hydrophobic within cavity likely explain low micromolar dissociation constants observed fluorescence competition assays. Our findings underscore critical roles chain length, headgroup functionality, conformation PFAS–FABP4 interactions. Given emerging implications role endocrine function, even subtle PFAS-induced perturbations could affect metabolic regulation disease risk. Overall, this work highlights value direct structural biochemical insights into paves way future research on PFAS transport toxicological outcomes.

Language: Английский

Citations

0
Bioaccumulation and Transfer of Legacy and Emerging Per- and Polyfluoroalkyl Substances throughout the Lifecycle of a Tropical Amphibian Species Fejervarya limnocharis DOI

Xingpei Cao,

Siru Yu,

Ziping Luo

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Pollutant bioaccumulation in amphibians is complex owing to their unique physiological characteristics and biphasic lifecycle. This study investigated per- polyfluoroalkyl substances (PFASs) water, insects, rice frogs (Fejervarya multistriata) throughout entire The median total PFAS concentrations were 1.15-5.53, 65.6, 7.31, 7.33, 2.24-31.6 ng/g dry weight insect, egg, tadpole, juvenile frog, adult frog samples, respectively. Concentrations of PFASs with protein-water distribution coefficients (log KPW) > 2 decreased from eggs tadpoles constant frogs. By contrast, log KPW < reached apex No growth dilution was observed for Stable isotope fatty acid compositions insect samples indicated little change diet sources during growth. factors 3 frogs, suggesting preferential accumulation low-proteinphilic water. distinct profiles development emphasize the need ecological toxicological studies conducted amphibian

Language: Английский

Citations

0
Hepatic Effects of PFAS DOI
Tracey Woodlief

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Serum concentrations of per- and poly-fluoroalkyl substances (PFAS) in Danish pregnant women—temporal trends during pregnancy, correlations with partners, associations with physical activity, and blood lipid concentrations DOI Creative Commons
Ida Karoline Bach Jensen, Esben Budtz‐Jørgensen, Christian Lindh

et al.

Environmental Health, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 2, 2025

Per- and polyflouralkyl substances (PFAS) are a group of persistent chemicals used extensively in industries consumer products due to their water-repellent properties. Studies have linked PFAS exposure adverse health effects, human PFAS, especially during pregnancy, is great concern. In this study, we report how serum concentrations pregnancy correlated with partners from the same household. Further, change course associations between blood lipid as well exploratory analyses physical activity concentrations. secondary analysis data FitMum study conducted 2018 2021, 216 healthy, pregnant women, 110 were included. Non-fasting venous samples collected mothers at three test visits delivery, where also collected. Serum all timepoints analyzed for 15 short- long-chained using liquid chromatography triple quadrupole linear ion trap mass spectrometry. Total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density (LDL-C) triglyceride measured delivery. Physical was wrist-worn tracker 24/7 inclusion before gestational age week + 0 throughout pregnancy. detected following PFAS: PFOS, PFOA, PFHxS, PFNA, PFDA, PFUnDA. The maternal median baseline were: PFOS: 4.09 ng/mL, PFOA: 0.81 PFHxS: 0.29 PFNA: 0.42 PFDA: 0.25 PFUnDA: 0.19 ng/mL. Partner 3-145% higher than concentration (except PFUnDA). within couples. All decreased significantly (PFOS -23.1 percent 95%-CI [-31.9;-13.2] delivery). associated increased HDL-C No found. Overall, households strongly correlated. positively associated. We found no registered ClinicalTrials.gov; NCT03679130; 20/09/2018.

Language: Английский

Citations

0
Estimation of species- and sex-specific PFAS pharmacokinetics in mice, rats, and non-human primates using a Bayesian hierarchical methodology DOI
Todd J. Zurlinden, Michael W. Dzierlenga, Dustin F. Kapraun

et al.

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 117336 - 117336

Published: April 1, 2025

Language: Английский

Citations

0
PFAS: The Journey from Wonder Chemicals to Environmental Nightmares and the Search for Solutions DOI Creative Commons

Duwage C. Perera,

Jay N. Meegoda

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(19), P. 8611 - 8611

Published: Sept. 24, 2024

Per- and polyfluoroalkyl substances (PFAS) are diverse synthetic chemicals manufactured over seven decades. It is an aliphatic molecule with a basic hydrophobic structure of carbon fluorine linked to hydrophilic end group. Due their physicochemical properties associated the unique structure, PFAS has been used in wide variety applications including aqueous film-forming foams (AFFF), paper, carpets, non-stick cookware, etc. as they make products resistant water, heat, stains. These molecules have drawn great attention recently for properties, high stability low degradability, so-called “Forever Chemicals”. strongest carbon-fluorine bond which makes them persistent environment. Hence it contaminates natural resources endangers public health. This review discusses discovery, development, evolution from wonder chemical era nightmare era, exposure its impacts on human health environment, current remediation techniques, future trends related products. The primary objective this identify knowledge gaps contamination, methods, possible alternatives.

Language: Английский

Citations

3
Effects of per- and polyfluoroalkyl substances on the liver: Human-relevant mechanisms of toxicity DOI
Amy Maerten, Ellen Callewaert, Julen Sanz-Serrano

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 954, P. 176717 - 176717

Published: Oct. 9, 2024

Language: Английский

Citations

2
PFAS exposure is associated with an unfavourable metabolic profile in infants six months of age DOI Creative Commons
Anne‐Lise Bjørke‐Monsen,

Kristin Holstad,

Sandra Huber

et al.

Environment International, Journal Year: 2024, Volume and Issue: 193, P. 109121 - 109121

Published: Nov. 1, 2024

Exposure to perfluoroalkyl substances (PFAS) are reported have numerous negative health effects and children especially vulnerable. The aim of this study was investigate whether maternal infant PFAS burden any impact on prenatal postnatal growth, liver lipid parameters in infants at age six months. Data diet growth parameters, as well blood samples were collected from healthy pregnant women week 18 the their months postpartum. analysed for enzymes, lipids PFAS. Maternal carboxylic acids (PFCA) fish dinner ≥ 3 days per pregnancy associated with reduced birth weight increased percent gain first life. Infant PFCA concentrations positively serum alanine aminotransferase total- LDL-cholesterol age. Our data demonstrate that exposure an unfavourable metabolic profile a very young This pattern is concerning it may be linked early conditioning later disease. It vital reduce fertile order prevent development disease next generation.

Language: Английский

Citations

0
An extended PFAS profiling of a Swedish subpopulation and mixture risk assessments using multiple approaches DOI Creative Commons
Josefin Engelhardt, Merle Plassmann, Jana M. Weiss

et al.

Environment International, Journal Year: 2024, Volume and Issue: 195, P. 109214 - 109214

Published: Dec. 17, 2024

Language: Английский

Citations

0