Ecotoxicology and Environmental Safety,
Journal Year:
2022,
Volume and Issue:
242, P. 113896 - 113896
Published: July 20, 2022
Nanoparticles
are
widely
used
in
industry
and
personal
care,
they
inevitably
end
up
people's
bodies
the
environment.
The
widespread
use
of
nanoparticles
has
raised
new
concerns
about
their
neurotoxicity,
as
can
enter
nervous
system
by
blood-brain
barrier.
In
neurotoxicity
testing,
zebrafish
provides
powerful
tools
to
overcome
limitations
other
models.
This
paper
will
provide
a
comprehensive
review
power
tests
neurotoxic
effects
nanoparticles,
including
inorganic,
organic,
metal-based
on
from
different
perspectives.
Such
information
be
predict
not
only
species
exposed
aquatic
environment
but
also
humans.
Chemical Research in Toxicology,
Journal Year:
2019,
Volume and Issue:
33(1), P. 95 - 118
Published: Oct. 18, 2019
Unpredicted
human
safety
events
in
clinical
trials
for
new
drugs
are
costly
terms
of
health
and
money.
The
drug
discovery
industry
attempts
to
minimize
those
with
diligent
preclinical
testing.
Current
standard
practices
good
at
preventing
toxic
compounds
from
being
tested
the
clinic;
however,
false
negative
toxicity
results
still
a
reality.
Continual
improvement
must
be
pursued
realm.
Higher-quality
therapies
can
brought
forward
more
information
about
potential
toxicities
associated
mechanisms.
zebrafish
model
is
bridge
between
vitro
assays
mammalian
vivo
studies.
This
powerful
its
breadth
application
tractability
research.
In
past
two
decades,
our
understanding
disease
biology
has
grown
significantly
owing
thousands
studies
on
this
tiny
vertebrate.
Review
summarizes
challenges
strengths
model,
discusses
3Rs
value
that
it
deliver,
highlights
translatable
untranslatable
biology,
brings
together
reports
recent
focusing
toxicology.
Experimental & Molecular Medicine,
Journal Year:
2021,
Volume and Issue:
53(3), P. 310 - 317
Published: March 1, 2021
Zebrafish
have
several
advantages
compared
to
other
vertebrate
models
used
in
modeling
human
diseases,
particularly
for
large-scale
genetic
mutant
and
therapeutic
compound
screenings,
biomedical
research
applications.
With
the
impactful
developments
of
CRISPR
next-generation
sequencing
technology,
disease
zebrafish
is
accelerating
understanding
molecular
mechanisms
diseases.
These
efforts
are
fundamental
future
precision
medicine
because
they
provide
new
diagnostic
solutions.
This
review
focuses
on
research,
mainly
developmental
disorders,
mental
metabolic
Frontiers in Neuroscience,
Journal Year:
2018,
Volume and Issue:
12
Published: Dec. 18, 2018
The
developing
central
nervous
system
and
the
blood
brain
barrier
are
especially
vulnerable
sensitive
to
different
chemicals,
including
environmental
contaminants
drugs.
Developmental
exposure
these
compounds
has
been
involved
in
several
neurological
disorders,
such
as
autism
spectrum
disorders
well
Alzheimer's
Parkinson's
diseases.
Zebrafish
(Danio
Rerio)
have
emerged
powerful
toxicological
model
systems
that
can
speed
up
chemical
hazard
assessment
be
used
extrapolate
neurotoxic
effects
chemicals
on
humans.
embryos
larvae
convenient
for
high-throughput
screening
of
due
their
small
size,
low-cost,
easy
husbandry,
transparency.
Additionally,
zebrafish
homologous
other
higher
order
vertebrates
terms
molecular
signaling
processes,
genetic
compositions,
tissue/organ
structures
neurodevelopment.
This
mini
review
underlines
potential
a
complementary
developmental
neurotoxicity
describes
endpoints
utilized
with
some
studies
illustrating
use.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
272, P. 116023 - 116023
Published: Jan. 30, 2024
An
in
vivo
model
is
necessary
for
toxicology.
This
review
analyzed
the
uses
of
zebrafish
(Danio
rerio)
toxicology
based
on
bibliometrics.
Totally
56,816
publications
about
from
2002
to
2023
were
found
Web
Science
Core
Collection,
with
Toxicology
as
top
6
among
all
disciplines.
Accordingly,
bibliometric
map
reveals
that
"toxicity"
has
become
a
hot
keyword.
It
further
most
common
exposure
types
include
acute,
chronic,
and
combined
exposure.
The
toxicological
effects
behavioral,
intestinal,
cardiovascular,
hepatic,
endocrine
toxicity,
neurotoxicity,
immunotoxicity,
genotoxicity,
reproductive
transgenerational
toxicity.
mechanisms
oxidative
stress,
inflammation,
autophagy,
dysbiosis
gut
microbiota.
toxicants
commonly
evaluated
by
using
nanomaterials,
arsenic,
metals,
bisphenol,
dioxin.
Overall,
provide
unique
well-accepted
investigate
mechanisms.
We
also
discussed
possible
ways
address
some
limitations
model,
such
combination
human
organoids
avoid
species
differences.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(8), P. 6038 - 6094
Published: Feb. 13, 2024
Two-dimensional
(2D)
materials
have
attracted
tremendous
interest
ever
since
the
isolation
of
atomically
thin
sheets
graphene
in
2004
due
to
specific
and
versatile
properties
these
materials.
However,
increasing
production
use
2D
necessitate
a
thorough
evaluation
potential
impact
on
human
health
environment.
Furthermore,
harmonized
test
protocols
are
needed
with
which
assess
safety
The
Graphene
Flagship
project
(2013-2023),
funded
by
European
Commission,
addressed
identification
possible
hazard
graphene-based
as
well
emerging
including
transition
metal
dichalcogenides,
hexagonal
boron
nitride,
others.
Additionally,
so-called
green
chemistry
approaches
were
explored
achieve
goal
safe
sustainable
this
fascinating
family
nanomaterials.
present
review
provides
compact
survey
findings
lessons
learned
Flagship.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
171, P. 116160 - 116160
Published: Jan. 21, 2024
The
aggrandised
advancement
in
utility
of
advanced
day-to-day
materials
and
nanomaterials
has
raised
serious
concern
on
their
biocompatibility
with
human
other
biotic
members.
In
last
few
decades,
understanding
toxicity
these
been
given
the
centre
stage
research
using
many
vitro
vivo
models.
Zebrafish
(Danio
rerio),
a
freshwater
fish
member
minnow
family
garnered
much
attention
due
to
its
distinct
features,
which
make
it
an
important
frequently
used
animal
model
various
fields
embryology
toxicological
studies.
Given
that
fertilization
development
zebrafish
eggs
take
place
externally,
they
serve
as
excellent
organism
for
studying
early
developmental
stages.
Moreover,
possess
comparable
genetic
composition
humans
share
almost
70%
genes
mammals.
This
particular
become
increasingly
popular,
especially
research.
serves
link
between
studies
analysis
It
is
appealing
choice
vertebrate
research,
when
employing
high-throughput
methods,
small
size,
swift
development,
relatively
affordable
laboratory
setup.
enhanced
comprehension
pathobiology
drug
toxicity.
review
emphasizes
recent
developments
screening
assays,
new
insights
gained
about
drugs
through
assays.
Specifically,
cardio,
neural,
and,
hepatic
toxicology
inferred
by
applications
nanoparticles
have
highlighted.
