Medicina Clínica (English Edition), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Clinical Microbiology Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
SUMMARYLymphatic filariasis (LF), a debilitating tropical disease caused by parasitic filarial worms, Wuchereria bancrofti, Brugia malayi, and timori, remains significant public health challenge in subtropical settings where the is endemic. The affects millions worldwide, leading to severe disability social stigma. Following World Health Assembly resolution WHA50.29 1997 encouraging Member States eliminate LF as problem, Global Programme Eliminate Lymphatic Filariasis (GPELF) was established 2000. establishment of GPELF paced way for global eradication efforts, with commitments from non-governmental organizations Merck donating drug ivermectin long it needed control disease. advances diagnosis have shown promising results, including developing novel diagnostic tools, therapeutic agents, integrated vector management surveillance strategies. This review explores latest our understanding epidemiology, transmission assessments, clinical manifestations, immune response infection. We further discuss current state development, treatment approaches, measures, highlighting importance continued research fight against this
Language: Английский
Citations
0
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 7, 2025
Neglected tropical diseases and malaria (NTDm) afflict the most disadvantaged communities, causing chronic devastating illnesses. The purpose of this study was to investigate epidemiological features NTDm from 1990 2021 provide essential information for policy choices reduce incidence NTDm. Global Burden Disease Study provided on incidence, mortality, prevalence, disability-adjusted life-year (DALY) rates NTDs 2021. Prevalence trends were analysed globally as well by region, sex, age. estimated annual percentage change (EAPC) used evaluate illness trends, connection between sociodemographic indicators (SDIs) disease burden investigated. To further examine patterns forecasts, age-period-cohort (APC) Bayesian age‒period‒cohort (BAPC) models used. On basis results analysis, main risk factors affecting explored in depth. In 2021, global age-standardized rate increased 24.12 (95% UI: -158.97-206.77) 1990. highest West Central Sub-Saharan Africa, with dengue, rabies being particularly prominent. standardized age, prevalence rates, mortality life years (DALYs) primarily observed children younger than five regions low SDIs. Analyses considering period, cohort indicated that has diminished populations born later. Forecasts suggest a minor rise (ASIRs) 2022 2035, whereas (ASPRs), (ASMRs), year (ASDRs) are anticipated decline. Major include child maternal malnutrition, growth failure, stunting underweight. varies age sex. This is case low-SDI regions. NTDm, specific strategies such strengthening health systems, fostering cross-sector collaboration, enhancing community participation essential. Integrated management requires multisectoral approach combines policy, care, education, research, involvement support sustainable development goals.
Language: Английский
Citations
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Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Neglected Tropical Diseases (NTDs) and malaria present considerable health obstacles, particularly impacting the socio-economic progress in at-risk areas. We aimed to estimate burden, trends, inequalities of NTDs globally, regionally, nationally from 1990 2021. The study utilized data Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2021, encompassing 204 countries territories, spanning 21 global regions, including diverse populations across different Socio-Demographic Index (SDI) levels. Primary outcomes were incidence prevalence rates, Disability-Adjusted Life Years (DALYs), age-standardized SDI, mortality 95% uncertainty intervals (UIs) for malaria. In reached 4259.54 per 100,000 population (95% UI: 3188.38-5488.91), a 0.60% increase since (4235.42 100,000, 3347.35-5282.14). Conversely, saw significant reduction 42.00%, 34451.84 32668.32-36407.73) 14454.15 2021 13659.74-15452.20). DALYs decreased by 18.00% 87.42 million years 59.03-141.60 million) 71.63 38.74-122.93 Regional analysis revealed variances, with Western Sub-Saharan Africa reporting highest rates Central Asia East showing substantial declines. also highlighted disparities among SDI lower regions bearing more disease burden. Age gender prominent, children under five years, who showed rates. demonstrates reducing burden globally over past three decades, terms DALYs. However, emphasizes ongoing challenges fully controlling these diseases. Continued efforts strengthen systems, low are essential sustain gains made address remaining challenges. findings advocate integrating economic development public strategies achieve effective control improved outcomes.
Language: Английский
Citations
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Journal of Plastic Surgery and Hand Surgery, Journal Year: 2025, Volume and Issue: 60, P. 96 - 101
Published: April 22, 2025
Introduction: Free flap reconstruction procedures are renowned for their duration and the requirement many staff large quantities of equipment. This single-centre cross-sectional study aimed to quantify total emissions related two such carried out at a district general hospital. Methods: One deep inferior epigastric perforator (DIEP) free procedure one anterolateral thigh (ALT) procedure, both in February 2024, were analysed. Data transport, anaesthetic duration, mass disposable equipment, quantity reusable surgical equipment consumption electricity heating relevant theatre areas collected. Emissions calculated using UK government conversion factors classified by scope contributory element as per Greenhouse Gas Protocol. Results: Total estimated 385.5 kgCO2eq DIEP 369.6 ALT. Scope 1 heating, atmospheric release incineration waste accounted 33.7% 35.6% ALT emissions. 2 use grid 44.8% 46.7% 3 cleaning supply chain 21.5% 17.7% Conclusion: Significant reductions may be achievable without significant infrastructural changes through initiatives reduce transport single-occupancy car, improving energy efficiency reducing single-use
Language: Английский
Citations
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Virulence, Journal Year: 2025, Volume and Issue: 16(1)
Published: May 11, 2025
Language: Английский
Citations
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Climate, Journal Year: 2025, Volume and Issue: 13(5), P. 104 - 104
Published: May 17, 2025
Background: This study investigates the relationship between climate variables and malaria incidence in Ethiopia’s Gambella region, a hotspot for transmission. Methods: Utilizing 30 years of satellite-derived data 10 records from Ethiopian Public Health Institute, this research analyzed trends correlations. Climate variables, including rainfall, temperature, relative humidity, were extracted using GPS global models NASA. Autoregressive modeling was employed to assess impact these on at different time lags (lag 0, 1, 2). Results: The analysis revealed significant upward temperature over 30-year period, coinciding with rise cases past decade. Rainfall exhibited delayed effects incidence, while humidity demonstrated both immediate persistent impacts. Relative lag 0 had strongest influence (IRR = 1.002, 95% CI: 1.001–1.003), whereas showed minimal 1.000, 1.000–1.001). Conclusions: These findings underscore critical role driving transmission highlight urgent need adaptation strategies, early warning systems, strengthened health infrastructure. Leveraging predictive expanding targeted interventions, such as insecticide-treated nets (ITNs), is essential mitigate climate-driven risks protect vulnerable communities similar regions
Language: Английский
Citations
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Infectious Diseases, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16
Published: Dec. 11, 2024
Climate change significantly influences the distribution and severity of tropical diseases. Rising temperatures, changing precipitation patterns, extreme weather events are transforming habitats vectors like mosquitoes ticks, promoting their proliferation geographic spread. These changes have facilitated resurgence diseases such as malaria, dengue, chikungunya fever in previously unaffected areas, including parts Europe Italy.
Language: Английский
Citations
3
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 18, 2024
Background Plasmodium falciparum is the most lethal malaria parasite. Recent phase 1b vaccine trials using P. reticulocyte binding protein homolog 5 (PfRh5) demonstrated safety and promising efficacy in preventing merozoite invasion. PfRh5 has emerged as a strong candidate due to its essential role invasion limited sequence variation. For effective development, especially high-transmission settings, strain-transcending activity must be considered. Ongoing monitoring of antigenic variation natural immune responses important estimate across geographically diverse populations. Methods Samples for this study were collected from four villages each Kigoma Geita regions, known transmission hotspots Tanzania. This community-based cross-sectional was conducted December 2022 July 2023. Genetic selection pressure on pfrh5 analyzed 164 asymptomatic isolates. The humoral response also assessed microarray with 242 sera samples patients same population. Finally, correlation analysis compare genetic response. Results results revealed that well conserved, but novel non-synonymous mutations found at D65H, H170N, I227M. Additionally, metrics indicated potential positive recent population expansion area, both which could influence effectiveness. Antigenicity screening variable sensitivity, ranging 3.3% Bunyambo 82.8% Rwantaba, no significant relationship between antigenicity parasitemia, haplotypes, or gender. However, age significantly associated ( ρ = 0.170, p 0.008). Conclusions These findings underscore need future PfRh5-based vaccines consider increasing geographical differences responses.
Language: Английский
Citations
2
BMJ, Journal Year: 2024, Volume and Issue: unknown, P. q1149 - q1149
Published: May 28, 2024
Fifty years after the formation of Special Programme for Research and Training in Tropical Diseases, John Reeder, Garry Aslanyan, Makiko Kitamura review their organisation's progress on advancing inclusive internationalism health research
Language: Английский
Citations
1
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 18, 2024
Mosquito ecology and behavior malaria parasite development display marked sensitivity to weather, in particular temperature precipitation. Therefore, climate change is expected profoundly affect epidemiology its transmission, spatiotemporal distribution consequent disease burden. However, transmission also complicated by other factors (e.g. urbanization, socioeconomic development, genetics, drug resistance) which together constitute a highly complex, dynamical system, where the influence of any single factor can be masked others. In this study, we therefore aim re-evaluate evidence underlying widespread belief that will increase worldwide transmission. We review two broad types study have contributed evidence-base: i) studies project changes due inferred relationships between environmental mosquito entomology, ii) regression-based look for associations variables prevalence. then employ simple statistical model show alone do not account observed variation Our raises several concerns about robustness analyses used advocacy around malaria. find that, while change's effect on plausible, empirical much less certain. Future research must become integrated into control programs, understood context as one among many. work outlines gaps modelling believe are priorities future research.
Language: Английский
Citations
0