Special Issue Editorial: Sustainably reducing snakebite burden by prioritising research(ers) in high-risk areas

Transactions of the Royal Society of Tropical Medicine and Hygiene, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Language: Английский

Bite First, Bleed Later: How Philippine Trimeresurus Pit Viper Venoms Hijack Blood Clotting

Toxins, Journal Year: 2025, Volume and Issue: 17(4), P. 185 - 185

Published: April 7, 2025

The Philippines has a high diversity of venomous snake species, but there is minimal information on their envenomation effects. This evidenced by the small number case reports, poor reporting cases, and absence specific antivenoms apart from one against Philippine cobra (Naja philippinensis). study sought to profile action selected pit viper venoms blood coagulation investigate whether commercially available non-specific can provide adequate protection these venoms. Venom vipers Trimeresurus flavomaculatus mcgregori were subjected assays, antivenom cross-neutralization tests, thromboelastography. Venoms both species able clot human plasma isolated fibrinogen. Consistent with pseudo-procoagulant/thrombin-like activity, resulting fibrin clots weak transient, thereby contributing net anticoagulation through depletion fibrinogen levels. Clotting factors fIXa fXa also inhibited venoms, further anticoagulant activity. Monovalent polyvalent Thai Red Cross Society effective indicating venom toxins; was rescue clotting greater degree than monovalent antivenom. Our findings highlight coagulopathic effects suggest utility procuring for areas in risk envenomation.

Language: Английский

Optimizing Anti-Snake Venom Strategies for Hemotoxic Envenomation in Northern India: Clinical Outcomes and Regional Challenge

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Language: Английский