Genomes of Microtus rodents highlight the importance of olfactory and immune systems in their fast radiation
Genome Biology and Evolution,
Journal Year:
2024,
Volume and Issue:
16(11)
Published: Oct. 24, 2024
Abstract
The
characterization
of
genes
and
biological
functions
underlying
functional
diversification
the
formation
species
is
a
major
goal
evolutionary
biology.
In
this
study,
we
investigated
fast
radiation
Microtus
voles,
one
most
speciose
group
mammals,
which
shows
strong
genetic
divergence
despite
few
readily
observable
morphological
differences.
We
produced
an
annotated
reference
genome
for
common
vole,
arvalis,
resequenced
genomes
10
different
lineages
spanning
speciation
continuum.
Our
full-genome
sequences
illustrate
recent
group,
identified
in
highly
divergent
genomic
windows
that
have
likely
particular
roles
their
radiation.
found
three
enriched
lineages:
olfaction,
immunity
metabolism.
particular,
olfaction-related
(mostly
olfactory
receptors
vomeronasal
receptors)
are
evolving
all
indicating
exceptional
importance
system
evolution
these
rodents.
Of
note
e.g.
shared
signature
among
vole
on
Olfr1019
has
been
associated
with
fear
responses
against
predator
odors
analyses
provide
genome-wide
basis
further
ecological
factors
processes
natural
sexual
selection
contributed
to
voles.
Language: Английский
Detection of divergent Orthohantavirus tulaense provides insight into wide host range and viral evolutionary patterns
npj Viruses,
Journal Year:
2024,
Volume and Issue:
2(1)
Published: Dec. 4, 2024
Abstract
Orthohantavirus
tulaense
(TULV)
is
a
member
of
the
orthohantavirus
genus
and
distributed
in
Europe
Asia.
To
shed
light
on
TULV
epidemiology
evolution,
we
trapped
wild
rodents
from
eastern
Turkiye
found
15
positive
rodents.
Sequencing
phylogenetic
analyses
confirmed
presence
diverse
strains.
Global
characterization
suggested
5
distinct
lineages.
phylogeographic
reconstruction
estimated
different
rooting
times
for
each
three
segments,
potential
ancestor
location
Eastern
Black
Sea
region,
strongly
supported
structure
with
11
clusters.
Dispersal
velocity
was
to
be
much
faster
than
some
other
orthohantaviruses.
seemed
have
lineages
evolving
genetically
closer
proto-Tula
virus.
Host
switching
estimates
events
Microtus
arvalis
M.
obscurus
irani
host-dependent
sub-clustering
within
geographic
clusters
substantial
evidence
no
clear
virus
jumps
.
Language: Английский