Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: May 5, 2023
Osteoporosis,
one
of
the
most
serious
and
common
complications
diabetes,
has
affected
quality
life
a
large
number
people
in
recent
years.
Although
there
are
many
studies
on
mechanism
diabetic
osteoporosis,
information
is
still
limited
no
consensus.
Recently,
researchers
have
proven
that
osteoporosis
induced
by
diabetes
mellitus
may
be
connected
to
an
abnormal
iron
metabolism
ferroptosis
inside
cells
under
high
glucose
situations.
However,
comprehensive
reviews
reported.
Understanding
these
mechanisms
important
implications
for
development
treatment
osteoporosis.
Therefore,
this
review
elaborates
changes
bones
conditions,
consequences
elevated
microenvironment
associated
cells,
impact
conditions
signaling
pathways
contribute
bone
loss
presence
metabolism.
Lastly,
we
also
elucidate
discuss
therapeutic
targets
with
relevant
medications
which
provides
some
inspiration
its
cure.
Molecular Metabolism,
Journal Year:
2022,
Volume and Issue:
60, P. 101470 - 101470
Published: March 15, 2022
With
long-term
metabolic
malfunction,
diabetes
can
cause
serious
damage
to
whole-body
tissue
and
organs,
resulting
in
a
variety
of
complications.
Therefore,
it
is
particularly
important
further
explore
the
pathogenesis
complications
develop
drugs
for
prevention
treatment.
In
recent
years,
different
from
apoptosis
necrosis,
ferroptosis
has
been
recognized
as
new
regulatory
mode
cell
death
involves
regulation
nuclear
receptor
coactivator
4
(NCOA4)-mediated
ferritinophagy.
Evidence
shows
that
ferritinophagy
play
significant
role
occurrence
development
Pharmacological Research,
Journal Year:
2022,
Volume and Issue:
187, P. 106635 - 106635
Published: Dec. 26, 2022
Osteoporosis
is
a
common
metabolic
bone
disease
that
results
from
the
imbalance
of
homeostasis
within
bone.
Intra-bone
dependent
on
precise
dynamic
balance
between
resorption
by
osteoclasts
and
formation
mesenchymal
lineage
osteoblasts,
which
comprises
series
complex
highly
standardized
steps.
Programmed
cell
death
(PCD)
(e.g.,
apoptosis,
autophagy,
ferroptosis,
pyroptosis,
necroptosis)
process
involves
cascade
gene
expression
events
with
tight
structures.
These
play
certain
role
in
regulating
metabolism
determining
fate
cells.
Moreover,
existing
research
has
suggested
natural
products
derived
wide
variety
dietary
components
medicinal
plants
modulate
PCDs
based
different
mechanisms,
show
great
potential
for
prevention
treatment
osteoporosis,
thus
revealing
emergence
more
acceptable
complementary
alternative
drugs
lower
costs,
fewer
side
effects
long-term
application.
Accordingly,
this
review
summarizes
types
field
osteoporosis.
perspective
targeting
PCDs,
also
discussed
roles
currently
reported
osteoporosis
involved
mechanisms.
Based
this,
provides
insights
into
new
molecular
mechanisms
reference
developing
anti-osteoporosis
future.
Bone Research,
Journal Year:
2023,
Volume and Issue:
11(1)
Published: March 1, 2023
Abstract
Ferroptosis,
a
unique
type
of
cell
death,
is
characterized
by
iron-dependent
accumulation
and
lipid
peroxidation.
It
closely
related
to
multiple
biological
processes,
including
iron
metabolism,
polyunsaturated
fatty
acid
the
biosynthesis
compounds
with
antioxidant
activities,
glutathione.
In
past
10
years,
increasing
evidence
has
indicated
potentially
strong
relationship
between
ferroptosis
onset
progression
age-related
orthopedic
diseases,
such
as
osteoporosis
osteoarthritis.
Therefore,
in-depth
knowledge
regulatory
mechanisms
in
diseases
may
help
improve
disease
treatment
prevention.
This
review
provides
an
overview
recent
research
on
its
influences
bone
cartilage
homeostasis.
begins
brief
systemic
metabolism
ferroptosis,
particularly
potential
ferroptosis.
presents
discussion
role
promotion
loss
degradation
inhibition
osteogenesis.
Finally,
it
focuses
future
targeting
treat
intention
inspiring
further
clinical
development
therapeutic
strategies.
International Journal of Biological Sciences,
Journal Year:
2022,
Volume and Issue:
18(10), P. 4118 - 4134
Published: Jan. 1, 2022
A
variety
of
programmed
cell
death
types
have
been
shown
to
participate
in
the
loss
smooth
muscle
cells
(SMCs)
during
development
aortic
dissection
(AD),
but
it
is
still
largely
unclear
whether
ferroptosis
involved
AD.In
present
study,
we
found
that
expression
key
regulatory
proteins,
solute
carrier
family
7
member
11
(SLC7A11),
suppressor
protein
1
(FSP1)
and
glutathione
peroxidase
4
(GPX4)
were
downregulated
aortas
Stanford
type
AD
(TAAD)
patients,
liproxstatin-1,
a
specific
inhibitor
ferroptosis,
obviously
abolished
β-aminopropionitrile
(BAPN)-induced
rupture
mice.Furthermore,
methyltransferase-like
3
(METTL3),
major
methyltransferase
RNA
m
6
A,
was
remarkably
upregulated
TAAD
levels
METTL3
negatively
correlated
with
SLC7A11
FSP1
human
aortas.Overexpression
SMCs
(HASMCs)
inhibited,
while
knockdown
promoted
expression.More
importantly,
overexpression
facilitated
imidazole
ketone
erastin-and
cystine
deprivation-induced
repressed
HASMCs.Overexpression
either
or
abrogated
effect
on
HASMC
ferroptosis.Therefore,
revealed
critical
cause
both
humans
mice
promotes
HASMCs
by
inhibiting
FSP1.Thus,
targeting
methylation
potential
novel
strategy
for
treatment
AD.
Frontiers in Endocrinology,
Journal Year:
2022,
Volume and Issue:
13
Published: March 29, 2022
The
global
diabetes
epidemic
and
its
complications
are
increasing,
thereby
posing
a
major
threat
to
public
health.
A
comprehensive
understanding
of
mellitus
(DM)
is
necessary
for
the
development
effective
treatments.
Ferroptosis
newly
identified
form
programmed
cell
death
caused
by
production
reactive
oxygen
species
an
imbalance
in
iron
homeostasis.
Increasing
evidence
suggests
that
ferroptosis
plays
pivotal
role
pathogenesis
diabetes-related
complications.
In
this
review,
we
summarize
potential
impact
regulatory
mechanisms
on
complications,
as
well
inhibitors
diabetic
Therefore,
developing
drugs
or
agents
target
may
provide
new
treatment
strategies
patients
with
diabetes.
Journal of Agricultural and Food Chemistry,
Journal Year:
2023,
Volume and Issue:
71(6), P. 2745 - 2761
Published: Jan. 31, 2023
Type
2
diabetic
osteoporosis
(T2DOP)
is
a
chronic
bone
metabolic
disease.
Compared
with
traditional
menopausal
osteoporosis,
the
long-term
high
glucose
(HG)
microenvironment
increases
patients'
risk
of
fracture
and
osteonecrosis.
We
were
accumulating
evidence
that
implicated
ferroptosis
as
pivotal
mechanism
glucolipotoxicity-mediated
death
osteocytes
osteoblast,
novel
form
programmed
cell
resulting
from
uncontrolled
lipid
peroxidation
depending
on
iron.
Vitamin
K2
(VK2),
fat-soluble
vitamin,
clinically
applied
to
prevent
improve
coagulation.
This
study
aimed
clarify
role
VK2
in
HG-mediated
ferroptosis.
established
mouse
T2DOP
model
by
intraperitoneal
injection
streptozotocin
solution
high-fat
high-sugar
diet.
also
cultured
marrow
mesenchymal
stem
cells
(BMSCs)
HG
simulate
environment
vitro.
Based
our
data,
inhibited
loss
ferroptosis,
latter
manifested
decreased
levels
mitochondrial
reactive
oxygen
species,
peroxidation,
malondialdehyde
increased
glutathione
In
addition,
treatment
was
capable
restoring
mass
strengthening
expression
SIRT1,
GPX4,
osteogenic
markers
distal
femurs.
As
for
further
exploration,
we
found
could
activate
AMPK/SIRT1
signaling,
knockdown
SIRT1
siRNA
prevented
VK2-mediated
positive
effect
HG-cultured
BMSCs.
Summarily,
ameliorate
through
activation
signaling
pathway
inhibit
Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 30, 2024
With
the
aging
global
population,
type
2
diabetes
mellitus
(T2DM)
and
osteoporosis(OP)
are
becoming
increasingly
prevalent.
Diabetic
osteoporosis
(DOP)
is
a
metabolic
bone
disorder
characterized
by
abnormal
tissue
structure
reduced
strength
in
patients
with
diabetes.
Studies
have
revealed
close
association
among
diabetes,
increased
fracture
risk,
disturbances
iron
metabolism.
This
review
explores
concept
of
ferroptosis,
non-apoptotic
cell
death
process
dependent
on
intracellular
iron,
focusing
its
role
DOP.
Iron-dependent
lipid
peroxidation,
particularly
impacting
pancreatic
β-cells,
osteoblasts
(OBs)
osteoclasts
(OCs),
contributes
to
The
intricate
interplay
between
dysregulation,
which
comprises
deficiency
overload,
DOP
has
been
discussed,
emphasizing
how
excessive
accumulation
triggers
ferroptosis
concise
overview
highlights
need
understand
complex
relationship
T2DM
OP,
ferroptosis.
aimed
elucidate
pathogenesis
provide
prospective
for
future
research
targeting
interventions
field
