Best1 mitigates ER stress induced by the increased cellular microenvironment stiffness in epilepsy DOI Creative Commons
Hao Wu,

Yicong Dong,

Qiang Meng

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 204, P. 106767 - 106767

Published: Dec. 12, 2024

Changes in brain tissue stiffness are closely linked to the development and diseases of nervous system. Endoplasmic reticulum (ER) stress plays a role various pathological processes related epilepsy. However, relationship between changes, ER stress, epilepsy remains unclear. This study aimed investigate impact Best1 upregulation on alleviating underlying mechanism. Additionally, we proposed protective strategy prevent cell death resulting from investigated expression levels stress-related proteins epileptic tissues varying stiffness. Atomic force microscopy revealed differences across lesion regions patients with The ECM were elevated higher Polypropionamide hydrogels used simulate extracellular matrix (ECM) levels. Basal increased stiffer hydrogel substrates. Furthermore, calcium-activated anion channel Bestrophin 1 (Best1) mitigated induced by both substrate thapsigargin. loss-of-function mutations inhibited this activity. mechanism involves endosomal sorting complex required for transport (ESCRT) components Best1, which helps mitigate stress. These findings suggest that cellular microenvironment may contribute neuronal during epileptogenesis. serve as against excessive stress-induced damage

Language: Английский

A look at MERCs as UPRmt regulatory hubs in age-associated heart diseases DOI Open Access

Gabriela Navarrete-Anastasio,

Zeltzin Alejandra Ceja-Galicia, Cecilia Zazueta

et al.

The Journal of Cardiovascular Aging, Journal Year: 2025, Volume and Issue: 5(1)

Published: Jan. 22, 2025

With the increase in life expectancy globally, challenge of dealing with aging becomes more prominent. Aging is a risk factor for several diseases, including cardiovascular disease. Mitochondria, which have long been studied relation to aging, play crucial role maintaining cellular homeostasis. However, there limitation interorganellar communication as organisms age. The unfolded protein response mitochondria (UPRmt) activated during stress maintain mitochondrial homeostasis and prevent accumulation damaged mitochondria. This involves signaling from nucleus, leading transcriptional changes. In context heart, this review explores terms function morphology. It also discusses impact UPRmt on cardiac diseases such heart failure, acute myocardial infarction, dilated cardiomyopathy. highlights potential mitochondria-endoplasmic reticulum contact sites (MERCs) modulating aging. Finally, it provides an update molecules that induce activity, potentially benefiting

Language: Английский

Citations

0
Modulation of arterial wall remodeling by mechanical stress: Focus on abdominal aortic aneurysm DOI
Maolin Qiao, Yaling Li, Sheng Yan

et al.

Vascular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

The rupture of an abdominal aortic aneurysm (AAA) poses a significant threat, with high mortality rate, and the mechanical stability arterial wall determines both its growth potential for rupture. Owing to extracellular matrix (ECM) degradation, wall-resident cells are subjected aberrant stress environment. In response stress, cellular signaling pathway is activated, initiating remodeling restore stability. A decline in signal responsiveness, coupled inadequate remodeling, significantly contributes AAA’s progressive expansion eventual this review, we summarize main stresses experienced by wall, emphasizing critical role ECM withstanding importance stress-exposed maintaining Furthermore, will discuss application biomechanical analyses as predictive tool assessing AAA

Language: Английский

Citations

0
Mitochondria-associated membranes (MAMs) in age-related heart diseases, role of endoplasmic reticulum stress DOI
Alejandro Silva‐Palacios, Zeltzin Alejandra Ceja-Galicia, Alejandra Zúñiga-Muñoz

et al.

Advances in pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Involvement of Matricellular Proteins in Cellular Senescence: Potential Therapeutic Targets for Age-Related Diseases DOI Open Access
Motomichi Fujita,

Manabu Sasada,

Takuya Iyoda

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6591 - 6591

Published: June 15, 2024

Senescence is a physiological and pathological cellular program triggered by various types of stress. Senescent cells exhibit multiple characteristic changes. Among them, the flattened enlarged morphology exhibited in senescent observed regardless stimuli causing senescence. Several studies have provided important insights into pro-adhesive properties senescence, suggesting that cell adhesion to extracellular matrix (ECM), which involved morphological changes, may play pivotal roles Matricellular proteins, group structurally unrelated ECM molecules are secreted environment, unique ability control binding receptors, including integrins. Recent reports certified matricellular proteins closely Through this biological function, thought pathogenesis age-related diseases, fibrosis, osteoarthritis, intervertebral disc degeneration, atherosclerosis, cancer. This review outlines recent on role inducing We highlight integrin-mediated signaling senescence provide new therapeutic options for diseases targeting

Language: Английский

Citations

3
The Research on Deep Learning-Driven Dimensionality Reduction and Strain Prediction Techniques Based on Flight Parameter Data DOI Creative Commons
Wenbo Huang, Rui Wang, Mengchuang Zhang

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(9), P. 3938 - 3938

Published: May 5, 2024

Loads and strains in critical areas play a crucial role aircraft structural health monitoring, the tracking of individual lifespans, compilation load spectra. Direct measurement actual flight loads presents challenges. This process typically involves using load-strain stiffness matrices, derived from ground calibration tests, to map measured parameters at locations. Presently, deep learning neural network methods are rapidly developing, offering new perspectives for this task. paper explores potential models predicting parameter strains, integrating preprocessing techniques, maneuver recognition (FMR), virtual tests wings, dimensionality reduction data through Autoencoder (AE) models, application Long Short-Term Memory (LSTM) predict strains. These efforts contribute prediction based on parameters, thereby enabling real-time assessment damage.

Language: Английский

Citations

1
Cystathionine γ lyase Attenuates Vascular Smooth Muscle Cell Senescence via Foxm1-Gas1 Pathway to Mediate Arterial Stiffness DOI
Qian Lin, Changting Cui,

Ying Zhao

et al.

Antioxidants and Redox Signaling, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Arterial stiffness, a hallmark of vascular aging, significantly contributes to hypertension and impaired organ perfusion. Vascular smooth muscle cell (VSMC) dysfunction, particularly VSMC senescence its interaction with is crucial in the pathogenesis arterial stiffness. Although hydrogen sulfide (H

Language: Английский

Citations

0
Identificación de nuevas dianas terapéuticas relacionadas con el estrés del retículo endoplasmático y con la disfunción mitocondrial para reducir el riesgo de rotura en el aneurisma de aorta ascendente degenerativo DOI
Rafael Almendra‐Pegueros, Antonio J. Barros-Membrilla,

Elvira Pérez-Marlasca

et al.

Clínica e Investigación en Arteriosclerosis, Journal Year: 2024, Volume and Issue: unknown, P. 100740 - 100740

Published: Oct. 1, 2024

Language: Английский

Citations

0
Mechanical stiffness across skin layers in human: a pilot study DOI
Wan-Yu Chi,

Hao-Wei Huang,

Gang‐Hui Lee

et al.

Tissue Barriers, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Mechanobiological forces play a pivotal role in the processes of skin homeostasis, wound healing and regeneration. Changes tissue stiffness are linked to various diseases. Using atomic force microscopy, we analyzed elastic modulus, representing mechanical stiffness, different layers group six participants, including 2 males 4 females, aged between 1 70 years. The layers, ranked from highest lowest epidermis, papillary dermis, upper reticular lower sebaceous gland, subcutaneous tissue. This study contributes more understanding physical properties skin, offering reference for further research on physiology or pathology.

Language: Английский

Citations

0
Best1 mitigates ER stress induced by the increased cellular microenvironment stiffness in epilepsy DOI Creative Commons
Hao Wu,

Yicong Dong,

Qiang Meng

et al.

Neurobiology of Disease, Journal Year: 2024, Volume and Issue: 204, P. 106767 - 106767

Published: Dec. 12, 2024

Changes in brain tissue stiffness are closely linked to the development and diseases of nervous system. Endoplasmic reticulum (ER) stress plays a role various pathological processes related epilepsy. However, relationship between changes, ER stress, epilepsy remains unclear. This study aimed investigate impact Best1 upregulation on alleviating underlying mechanism. Additionally, we proposed protective strategy prevent cell death resulting from investigated expression levels stress-related proteins epileptic tissues varying stiffness. Atomic force microscopy revealed differences across lesion regions patients with The ECM were elevated higher Polypropionamide hydrogels used simulate extracellular matrix (ECM) levels. Basal increased stiffer hydrogel substrates. Furthermore, calcium-activated anion channel Bestrophin 1 (Best1) mitigated induced by both substrate thapsigargin. loss-of-function mutations inhibited this activity. mechanism involves endosomal sorting complex required for transport (ESCRT) components Best1, which helps mitigate stress. These findings suggest that cellular microenvironment may contribute neuronal during epileptogenesis. serve as against excessive stress-induced damage

Language: Английский

Citations

0