Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(6), P. 1774 - 1774
Published: March 20, 2024
Polycystic
ovary
syndrome
(PCOS)
is
a
multisystem
disorder
that
presents
with
variety
of
phenotypes
involving
metabolic,
endocrine,
reproductive,
and
psychological
symptoms
signs.
Women
PCOS
are
at
increased
risk
pregnancy
complications
including
implantation
failure,
miscarriage,
gestational
diabetes,
fetal
growth
restriction,
preterm
labor,
pre-eclampsia
(PE).
This
may
be
attributed
to
the
presence
specific
susceptibility
features
associated
before
during
pregnancy,
such
as
chronic
systemic
inflammation,
insulin
resistance
(IR),
hyperandrogenism,
all
which
have
been
an
complications.
Many
reversible
following
lifestyle
interventions
diet
exercise,
pregnant
women
healthy
found
lower
complications,
PE.
narrative
synthesis
summarizes
evidence
investigating
PE
role
nutritional
factors
in
PCOS.
The
findings
suggest
beneficial
aspects
management
PCOS,
recommended
evidence-based
international
guidelines,
extend
improved
outcomes.
Identifying
high-risk
will
allow
targeted
interventions,
early-pregnancy
screening,
surveillance
for
should
included
assessment
algorithms
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4821 - 4821
Published: April 28, 2024
Numerous
post-translational
modifications
are
involved
in
oocyte
maturation
and
embryo
development.
Recently,
lactylation
has
emerged
as
a
novel
epigenetic
modification
implicated
the
regulation
of
diverse
cellular
processes.
However,
it
remains
unclear
whether
occurs
during
development
Herein,
lysine
(Kla)
were
determined
mouse
early
by
immunofluorescence
staining.
Exogenous
lactate
was
supplemented
to
explore
consequences
modulating
histone
levels
on
processes
transcriptomics.
Results
demonstrated
that
lactylated
proteins
widely
present
mice
with
tissue-
cell-specific
distribution.
During
maturation,
for
H3K9la,
H3K14la,
H4K8la,
H4K12la
most
intense
at
germinal
vesicle
(GV)
stage
subsequently
weakened
or
disappeared.
Further,
supplementing
culture
medium
10
mM
sodium
elevated
both
rate
Kla
GV
oocytes,
there
substantial
increases
metaphase
II
(MII)
oocytes.
It
altered
transcription
molecules
oxidative
phosphorylation.
Moreover,
changed
dynamically
embryogenesis.
Sodium
enhanced
significantly
increased
lactylation,
while
impacting
glycolytic
gene
transcription.
This
study
reveals
roles
development,
providing
new
insights
improving
quality.
Open Biology,
Journal Year:
2025,
Volume and Issue:
15(2)
Published: Feb. 1, 2025
Glycolysis,
present
in
most
organisms,
is
evolutionarily
one
of
the
oldest
metabolic
pathways.
It
has
great
relevance
at
a
physiological
level
because
it
responsible
for
generating
ATP
cell
through
conversion
glucose
into
pyruvate
and
reducing
nicotinamide
adenine
dinucleotide
(NADH)
(that
may
be
fed
electron
chain
mitochondria
to
produce
additional
by
oxidative
phosphorylation),
as
well
producing
intermediates
that
can
serve
substrates
other
processes.
Glycolysis
takes
place
10
consecutive
chemical
reactions,
each
which
catalysed
specific
enzyme.
Although
energy
transduction
metabolism
main
function
this
pathway,
involvement
virulence,
growth,
pathogen–host
interactions,
immunomodulation
adaptation
environmental
conditions
are
functions
attributed
pathway.
In
humans,
where
glycolysis
occurs
mainly
cytosol,
mislocalization
some
glycolytic
enzymes
various
subcellular
locations,
alterations
their
expression
regulation,
been
associated
with
development
progression
diseases.
review,
we
describe
role
pathogenesis
diseases
clinical
interest.
addition,
potential
these
targets
drug
use
diagnostic
prognostic
markers
pathologies
also
discussed.
MedComm,
Journal Year:
2025,
Volume and Issue:
6(3)
Published: Feb. 23, 2025
ABSTRACT
The
maintenance
of
endocrine
homeostasis
in
the
placenta
is
crucial
for
ensuring
successful
pregnancy.
An
abnormally
elevated
production
placental
testosterone
(T
0
)
has
been
documented
patients
with
early‐onset
preeclamptic
(E‐PE).
However,
underlying
mechanisms
remain
unclear.
In
this
study,
we
found
that
E‐PE
placentas
exhibited
significantly
increased
expressions
3β‐HSD1
(3β‐Hydroxysteroid
Dehydrogenase
1)
and
17β‐HSD3
(17β‐Hydroxysteroid
3),
rate‐limiting
enzymes
T
synthesis.
This
was
strongly
correlated
an
level
O‐linked
N‐acetylglucosaminylation
(O‐GlcNAcylation)
GATA3
(GATA
binding
protein
3).
human
trophoblast
cells,
O‐linked‐N‐acetylglucosamine
(O‐GlcNAc)
modification
on
Thr
322
stabilized
enhanced
transcriptional
regulation
17β‐HSD3,
thereby
increasing
production.
Hypoxia,
a
well‐established
pathological
factor
PE,
O‐GlcNAcylation
cells.
Our
findings
suggest
hypoxia‐induced
overactive
contributes
to
exacerbated
placentas.
These
provide
new
perspective
pathogenesis
from
standpoint
posttranslational
may
illuminate
novel
therapeutic
strategies
adverse
pregnancy
outcomes
such
as
E‐PE.
Placenta,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Although
the
significance
of
metabolic
remodelling
in
maintaining
homeostasis
at
maternal-foetal
interface
has
been
established,
research
on
its
implications
miscarriage
remains
limited.
Immunofluorescence,
qRT-PCR,
and
western
blotting
were
used
to
detect
expression
SNAI1
normal
villi.
The
function
zinc-finger
transcription
factor
was
evaluated
three-dimensional
(3D)
trophoblast
spheroids.
Lactate
production
assays
performed
investigate
effect
lactate
pyruvate
dehydrogenase
kinase
1
(PDK1)
expression.
Immunofluorescence
Furthermore,
role
PDK1
confirmed
clinical
samples.
is
significantly
downregulated
villi
patients
with
miscarriages.
promotes
proliferation,
invasion,
inhibits
apoptosis
HTR8/SVneo
3D
glycolytic
enzyme
identified
as
a
downstream
target
plays
crucial
regulating
trophoblasts.
upregulates
nuclear
localisation.
miscarriage.
Trophoblast
spheroids
may
serve
reliable
models
placenta.
regulatory
mechanisms
mediated
by
SNAI1/PDK1
have
elucidated.
We
provide
new
clues
regarding
mechanism
from
perspective
present
evidence
supporting
potential
diagnostic
marker.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(9), P. 4977 - 4977
Published: May 2, 2024
One-carbon
(1-C)
metabolic
deficiency
impairs
homeostasis,
driving
disease
development,
including
infertility.
It
is
of
importance
to
summarize
the
current
evidence
regarding
clinical
utility
1-C
metabolism-related
biomolecules
and
methyl
donors,
namely,
folate,
betaine,
choline,
vitamin
B12,
homocysteine
(Hcy),
zinc,
as
potential
biomarkers,
dietary
supplements,
culture
media
supplements
in
context
medically
assisted
reproduction
(MAR).
A
narrative
review
literature
was
conducted
PubMed/Medline
database.
Diet,
ageing,
endocrine
milieu
individuals
affect
both
metabolism
fertility
status.
In
vitro
fertilization
(IVF)
techniques,
conditions
particular,
have
a
direct
impact
on
activity
gametes
embryos.
Critical
analysis
indicated
that
zinc
supplementation
cryopreservation
may
be
promising
approach
reducing
oxidative
damage,
while
female
serum
levels
employed
possible
biomarker
for
predicting
IVF
outcomes.
Nonetheless,
level
low,
future
studies
are
needed
verify
these
data.
processes,
redox
defense
epigenetic
regulation,
compromised
IVF-derived
The
study
lead
way
towards
improving
MAR
efficiency
safety
ensuring
lifelong
health
infants.
Hypertension,
Journal Year:
2024,
Volume and Issue:
81(7), P. 1537 - 1549
Published: May 16, 2024
Preeclampsia
is
a
multifaceted
syndrome
that
includes
maternal
vascular
dysfunction.
We
hypothesize
increased
placental
glycolysis
and
hypoxia
in
preeclampsia
lead
to
levels
of
methylglyoxal
(MGO),
consequently
causing
