New triterpenoid saponins isolated from the leaves of Astragalus membranaceus (Fisch.) Bge. and their neuroprotective effects

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 156, P. 108149 - 108149

Published: Jan. 9, 2025

Language: Английский

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Caffeic Acid Protects Against Ulcerative Colitis via Inhibiting Mitochondrial Apoptosis and Immune Overactivation in Drosophila

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 2157 - 2172

Published: March 1, 2025

Ulcerative colitis (UC) is a chronic intestinal inflammation that prone to relapse and difficult fully recover; therefore, there need for safer alternative treatments. Caffeic acid (CA) natural polyphenolic compound has antioxidant anti-inflammatory properties. However, the beneficial effects mechanisms of action CA in UC remain unclear. This study evaluated protective effect against dextran sulfate sodium (DSS)-induced injury Drosophila melanogaster model. Oral administration significantly reduced body damage flies, improved their survival rate, restored damaged digestion, locomotion. supplementation alleviated flies by restoring excretion balance, repairing atrophy, improving acid-base balance imbalance, inhibiting structural destruction, epithelial cell death stem (ISC) excessive proliferation, reducing number harmful bacteria. Mechanistic studies found expression Toll Imd pathway genes (including Myd88, Dif, PGRP-LC, Imd, Rel, Dpt), ROS levels apoptosis-related (Debcl, Cyt-c-p, DrlCE, Dronc, Dark), increased ATP MFN2 levels. mainly signaling pathways apoptosis mediated mitochondrial damage. These findings suggest holds promise as potential therapeutic treatment.

Language: Английский

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Neuroprotective triterpenoids from Astragalus membranaceus stems and leaves: Anti-inflammatory and anti-apoptotic mechanisms for memory improvement via in vivo and in vitro models

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108492 - 108492

Published: April 1, 2025

Language: Английский

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Protective effect of astragaloside IV against zinc oxide nanoparticles induced human neuroblastoma SH-SY5Y cell death: a focus on mitochondrial quality control

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Language: Английский

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