The FASEB Journal, Journal Year: 2024, Volume and Issue: 38(23)

Published: Dec. 9, 2024

Mycoplasma bovis has emerged as a significant pathogen in cattle, leading to considerable economic losses the cattle industry. It is associated with various clinical syndromes, including pneumoniae, mastitis, and arthritis. The innate immune response, particularly macrophages, plays crucial role combating infections caused by such pathogens. release of macrophage extracellular traps (METs) represents novel defense mechanism employed macrophages; however, impact M. on formation METs bovine macrophages remains unknown. Therefore, primary objective this study investigate which affects evaluate their bactericidal efficacy. Our findings revealed that cell lines released DNA fibrils colocalized histones cellular proteins response infection, visualized confocal scanning electron microscopy. Moreover, was found depend NADPH oxidase, for reactive oxygen species generation. Importantly, led lysis indicated lactate dehydrogenase, process be independent apoptosis pyroptosis. infection effective both killing restricting its growth. Overall, our first described how were produced responded demonstrated function bacterial killing, helpful improve understanding host's against pathogen.

Language: Английский