Post-translational acylation of proteins in cardiac hypertrophy

Nature Reviews Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Language: Английский

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Mechanical Forces, Nucleus, Chromosomes, and Chromatin

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 354 - 354

Published: March 1, 2025

Individual cells and within the tissues organs constantly face mechanical challenges, such as tension, compression, strain, shear stress, rigidity of cellular extracellular surroundings. Besides external forces, their components are also subjected to intracellular pulling, pushing, stretching, created by sophisticated force-generation machinery cytoskeleton molecular motors. All these stressors switch on mechanotransduction pathways, allowing respond adapt. Mechanical force-induced changes at cell membrane transmitted nucleus its nucleoskeleton, affecting nucleocytoplasmic transport, chromatin conformation, transcriptional activity, replication, genome, which, in turn, orchestrate behavior. The memory mechanoresponses is stored epigenetic structure modifications. state response acellular environment determines identity, fate, immune invading pathogens. Here, we give a short overview latest developments understanding processes, emphasizing effects nuclei, chromosomes, chromatin.

Language: Английский

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Mechanotransduction in Development: A Focus on Angiogenesis

Biology, Journal Year: 2025, Volume and Issue: 14(4), P. 346 - 346

Published: March 27, 2025

Cells respond to external mechanical cues and transduce these forces into biological signals. This process is known as mechanotransduction requires a group of proteins called mechanosensors. peculiar class receptors include extracellular matrix proteins, plasma membrane the cytoskeleton nuclear envelope. These cell components are responsive wide spectrum physical including stiffness, tensile force, hydrostatic pressure shear stress. Among mechanotransducers, Transient Receptor Potential (TRP) PIEZO family members mechanosensitive ion channels, coupling force transduction with intracellular cation transport. Their activity contributes embryo development, tissue remodeling repair, homeostasis. In particular, vessel development driven by hemodynamic such flow direction Perturbed involved in several pathological vascular phenotypes hereditary hemorrhagic telangiectasia. review conceived summarize most recent findings development. We first collected main features proteins. However, we focused on role during Mechanosensitive channels their function also discussed, focus brain morphogenesis.

Language: Английский

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RPS6KA1 is a histone acetylation-related oncoprotein in acute myeloid leukemia which is targeted by afzelin

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 27, 2024

Language: Английский

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