Cbfβ: A key regulator in skeletal stem cell differentiation, bone development, and disease

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(4)

Published: Feb. 25, 2025

Abstract The skeletal system comprises closely related yet functionally distinct bone and cartilage tissues, regulated by a complex network of transcriptional factors signaling molecules. Among these, core‐binding factor subunit beta (Cbfβ) emerges as critical co‐transcriptional that stabilizes Runx proteins, playing indispensable roles in development homeostasis. Emerging evidence from genetic mouse models has highlighted the essential role Cbfβ directing lineage commitment mesenchymal stem cells (MSCs) their differentiation into osteoblasts chondrocytes. Notably, deficiency is strongly associated with severe dysplasia, affecting both endochondral intramembranous ossification during embryonic postnatal development. In this review, we synthesize recent advancements understanding structural molecular functions Cbfβ, particular focus on its interactions key pathways, including BMP/TGF‐β, Wnt/β‐catenin, Hippo/YAP, IHH/PTHrP. These pathways converge Cbfβ/RUNX2 complex, which orchestrates gene expression program for osteogenesis, formation, integration these networks ensures precise regulation development, remodeling, repair. Furthermore, successful local delivery to address abnormalities underscores potential novel therapeutic target disorders such cleidocranial osteoarthritis, metastases. By elucidating mechanisms underlying function insights not only advance our biology but also offer promising avenues clinical intervention, ultimately improving outcomes patients disorders.

Language: Английский

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Regulation of Skeletogenic Pathways by m6A RNA Modification: A Comprehensive Review

Calcified Tissue International, Journal Year: 2025, Volume and Issue: 116(1)

Published: April 3, 2025

Language: Английский

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An update on bone in diabetes

Current Opinion in Endocrinology Diabetes and Obesity, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Purpose of review As the prevalence diabetes mellitus (DM) increases due to urbanization, aging populations, and lifestyle changes, it is crucial understand mechanisms, diagnosis, treatment diabetes-related bone disorders. This highlights recent advancements in field explores their implications for clinical practice research. Recent findings studies have elucidated complex interplay between health, emphasizing roles advanced glycation end-products (AGEs), inflammation, oxidative stress, senescence, molecular signaling pathways such as Wnt, mammalian target rapamycin (mTOR), exosome-mediated mechanisms. Key highlight significance marrow adipose tissue (BMAT) metabolism impact sarcopenia on fracture risk. Novel diagnostic tools, including miRNA biomarkers emerging therapeutic strategies like exosome-based therapies glycogen synthase kinase 3 beta (GSK3β) inhibitors, offer promising opportunities improving health diabetic patients. Summary The underscore need integrated managing complications. Clinicians should prioritize early screening, interventions, personalized pharmacological treatments mitigate risk improve Future research focus optimizing tools developing targeted address unique challenges disorders related diabetes.

Language: Английский

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The signaling landscape of insulin-like growth factor 1

Journal of Biological Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 108047 - 108047

Published: Dec. 1, 2024

Language: Английский

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