Neurobiological mechanisms of nicotine's effects on feeding and body weight

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 169, P. 106021 - 106021

Published: Jan. 16, 2025

Language: Английский

Multiomics approach reveals the comprehensive interactions between nutrition and children’s gut microbiota, and microbial and host metabolomes

Nutrition Journal, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 29, 2025

The gut microbiome can modulate nutrient metabolism to produce many metabolites interacting with the host. However, intricate interactions among dietary intake, and metabolites, host need be further explored although some studies have been devoted it. Here, in a cross-sectional studies, 88 children aged 2–12 years were enrolled from northwestern China. intake data collected via designed food frequency questionnaire calculate plant-based diet indices (PDIs). Stool plasma samples for metagenomic broad-targeted metabolomic analysis. Spearman's rank correlation was used describe associations between nutrients/PDIs microbiota metabolites. PDI significantly positively associated Bilophila wadsworthia, Bacteroides thetaiotaomicron, Alistipes indistinctus, etc., but obviously negatively correlated Roseburia intestinalis, Faecalibacterium prausnitzii, etc. these species showed no significant either healthy (hPDI) or unhealthy (uPDI). Interestingly, hPDI related species, including Ruminococcus bicirculans, uPDI, vice versa. above trends also observed PDIs predicted microbial functional pathways, metabolome. Notably, pathways focused mainly on substances energy metabolism. fecal contents of P-aminobenzoate, chenodeoxycholic acid, 4,6-dihydroxyquinoline, quinoline-4,8-diol, those TMAO, FFA, creatine phosphate, In plasma, sarcosine, ornithine, L-histidine, distinctly FFAs, carnitine C2:0, Strikingly, index is increased levels tryptophan metabolism, whereas (uPDI) linked tyrosine sphingolipid which are commonly Western diets. Our provide reliable support comprehensive understanding effects lay foundation diet-gut microbiota-microbial

Language: Английский

Gut Microbiota in Epilepsy: How Antibiotics Induce Dysbiosis and Influence Seizure Susceptibility

Microbiological Research, Journal Year: 2025, Volume and Issue: 298, P. 128225 - 128225

Published: May 18, 2025

Language: Английский