SPP1 macrophages across diseases: A call for reclassification? DOI Creative Commons
Alessio Reggio, Claudia Fuoco, Rebecca Deodati

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(5)

Published: March 6, 2025

SPP1+ macrophages, characterized by elevated expression of the osteopontin gene (secreted phosphoprotein 1, SPP1), have emerged as key players in various pathological contexts, including aging, chronic inflammatory diseases, and cancer. While frequently classified a subclass tumor-associated macrophages oncological settings, their presence noncancer conditions, such aging-related disorders muscular suggests broader role beyond tumors. These share conserved traits, fibrosis promotion, extracellular matrix remodeling, immune modulation, often linked to poor clinical outcomes. This perspective explores multifaceted roles across diseases advocates for reclassification distinct macrophage subtype associated with or prolonged inflammation. Recognizing cross-disease relevance could reshape biology inform targeted therapeutic strategies.

Language: Английский

SPP1 macrophages across diseases: A call for reclassification? DOI Creative Commons
Alessio Reggio, Claudia Fuoco, Rebecca Deodati

et al.

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(5)

Published: March 6, 2025

SPP1+ macrophages, characterized by elevated expression of the osteopontin gene (secreted phosphoprotein 1, SPP1), have emerged as key players in various pathological contexts, including aging, chronic inflammatory diseases, and cancer. While frequently classified a subclass tumor-associated macrophages oncological settings, their presence noncancer conditions, such aging-related disorders muscular suggests broader role beyond tumors. These share conserved traits, fibrosis promotion, extracellular matrix remodeling, immune modulation, often linked to poor clinical outcomes. This perspective explores multifaceted roles across diseases advocates for reclassification distinct macrophage subtype associated with or prolonged inflammation. Recognizing cross-disease relevance could reshape biology inform targeted therapeutic strategies.

Language: Английский

Citations

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