Bacteria-based drug delivery for treating non-oncological diseases
Zhenping Cao,
No information about this author
Yan Pang,
No information about this author
Jun Pu
No information about this author
et al.
Journal of Controlled Release,
Journal Year:
2024,
Volume and Issue:
366, P. 668 - 683
Published: Jan. 18, 2024
Language: Английский
Unlocking the Potential of Antimicrobial Peptides: Cutting-Edge Advances and Therapeutic Potential in Combating Bacterial Keratitis
Bioconjugate Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 19, 2025
Bacterial
keratitis
is
a
prevalent,
and
severe
corneal
illness
resulting
from
bacterial
pathogens.
Failure
to
administer
timely
suitable
therapy
may
lead
opacity,
ulceration,
significant
vision
impairment,
or
potential
blindness.
Current
clinical
interventions
for
involve
the
administration
of
topical
antimicrobial
agents
systemic
antibiotics.
However,
misuse
overuse
antibiotics
have
led
rapid
emergence
antibiotic-resistant
bacteria.
Additionally,
restricted
antibacterial
spectrum
possible
adverse
effects
provided
considerable
obstacles
traditional
therapies.
This
highlights
urgent
need
novel
highly
effective
agents.
Antimicrobial
peptides
(AMPs)
are
class
naturally
occurring
synthetically
designed
small
molecules
that
gained
attention
due
their
unique
mechanisms
low
risk
resistance
development.
AMPs
exhibit
promising
in
treating
through
direct
mechanisms,
such
as
inhibiting
cell
wall
synthesis,
disrupting
membranes,
interfering
with
nucleic
acid
metabolism,
well
indirect
including
modulation
host
immune
response.
review
provides
comprehensive
overview
advancements
treatment
keratitis.
It
emphasizes
role
various
modification
strategies
artificial-intelligence-assisted
design
enhancing
efficacy,
stability,
biocompatibility
AMPs.
Furthermore,
this
discusses
latest
progress
combining
delivery
systems
improved
therapeutic
outcomes.
Finally,
current
challenges
future
perspectives
treatment,
providing
valuable
insights
developing
high
safety
Language: Английский
Bacterial Insights: Unraveling the Ocular Microbiome in Glaucoma Pathogenesis
Frontiers in Bioscience-Landmark,
Journal Year:
2024,
Volume and Issue:
29(8)
Published: Aug. 23, 2024
This
review
explores
the
connection
between
ocular
surface
microbiome
and
glaucoma,
highlighting
its
impact
on
disease
progression.
Beginning
with
an
overview
of
global
glaucoma
significance,
it
emphasizes
importance
understanding
cellular
characteristics
microbiology
microbiome.
A
search
was
conducted
PubMed
Cochrane
Library
databases
using
phrase
"ocular
glaucoma".
0
records
were
returned
from
while
21
PubMed.
total
results
retrieved
2017
to
2024.
comprised
one
opinion
paper,
four
original
research
articles,
16
reviews.
covered
anatomy
surface,
advanced
analysis
methods,
It
also
delved
into
dysbiosis
in
addressing
altered
microbial
communities
their
potential
role
The
intricate
interplay
host's
immune
system
is
explored,
emphasizing
crosstalk
inflammatory
responses.
concludes
by
discussing
therapeutic
implications,
including
modulating
microbiota
future
treatment
strategies.
Understanding
healthy
glaucomatous
eyes
can
help
researchers
clinicians
innovative
approaches
health.
Language: Английский
Investigating the Causal Relationship Between Gut Microbiota and Allergic Conjunctivitis: A Two-Sample Mendelian Randomization Study
Yuanyang Huang,
No information about this author
Shu Wang,
No information about this author
Jinfang Huang
No information about this author
et al.
Ocular Immunology and Inflammation,
Journal Year:
2024,
Volume and Issue:
32(10), P. 2411 - 2420
Published: Oct. 1, 2024
To
investigate
the
causal
association
between
gut
microbiota
and
allergic
conjunctivitis.
Language: Английский