Cited by A Retrospective Data Audit of Outcome of Moderate and Severe Covid-19 Patients Who Had Received MP and Dex: A Single Center Study

The comparative effectiveness of methylprednisolone versus dexamethasone on in-hospital mortality in patients with severe or critical COVID-19: a retrospective observational study DOI

Abdullah Wagley, Samar Fatima, Safia Awan

et al.

Therapeutic Advances in Infectious Disease, Journal Year: 2025, Volume and Issue: 12

Published: April 1, 2025

Background: Studies comparing the effectiveness of dexamethasone versus methylprednisolone for treating severe-to-critical COVID-19 have produced conflicting results. This study aimed to evaluate impact compared with on in-hospital mortality among patients severe or critical COVID-19. Objectives: The objective this was assess in comparison reducing suffering from pneumonia. Design: a retrospective observational conducted at tertiary care academic medical center. Methods: Clinical data 706 hospitalized Karachi, Pakistan, were reviewed. Of these patients, 217 received either oral intravenous dexamethasone, and 393 treated methylprednisolone. primary outcome mortality, while secondary outcomes included length hospitalization need mechanical ventilation. Results: group had male predominance (74% vs 54%; p < 0.001). However, there no significant difference median age between (55 years) (57 ( = 0.09). Mortality significantly higher (13.7% 3.2%, Multivariable analysis showed that associated lower (adjusted odds ratio (aOR): 0.24; 95% CI: 0.09–0.62; 0.003). Furthermore, shorter hospital stay (aOR: 0.87 (95% 0.82–0.92)) group. A proportion required invasive ventilation 3.2%; Conclusion: Dexamethasone reduced

Language: Английский

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Liberation and discharge status of older patients after invasive mechanical ventilation: a retrospective cohort study DOI

Ayaka Sakamoto, Ryota Inokuchi, Masao Iwagami

et al.

BMC Geriatrics, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 5, 2025

Data on the proportion of patients liberated from invasive mechanical ventilation (IMV) and prognosis those who have undergone IMV are limited. Objective data important when discussing preference for IMV. Therefore, this study explored both liberation after in older Japan. We conducted a retrospective cohort using claim April 2014 to March 2019 National Health Insurance, Late Elders' Long-Term Care Insurance Tsukuba City, Patients aged ≥ 65 years underwent were included, died within 3 days intubation excluded. A descriptive analysis discharge status day 180 was including stratification by age categories care level (CL) < or 3. The chi-square Fisher's exact test assess whether differed among CLs. In total, 272 included study, median 78 (interquartile range: 73-84). duration 9.0 days. Pneumonia most frequent main diagnosis (12.5%). 73.5% achieved 42.6% discharged alive until 180, while 19.9% hospitalized 37.5% deceased 180. did not differ However, requiring CL longer, significantly higher than that (35.1% vs 17.4%, p = 0.012). This shows many can be successfully one third hospital fifth required prolonged hospitalization. hospitalization likely longer it may discuss only potential difficulty liberation, but also convey risks undesired outcomes physical function decline considering

Language: Английский

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Liberation and Discharge Status of Older Patients After Invasive Mechanical Ventilation: A Retrospective cohort study DOI

Ayaka Sakamoto, Ryota Inokuchi, Masao Iwagami

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 8, 2024

Abstract Background Data on the proportion of patients liberated from invasive mechanical ventilation (IMV) and prognosis those who have undergone IMV are limited. Objective data important when discussing preference for IMV. Therefore, this study explored both liberation after in older Japan. Methods We conducted a retrospective cohort using claim April 2014 to March 2019 National Health Insurance, Late Elders' Long-Term Care Insurance Tsukuba City, Patients aged ≥ 65 years underwent were included died within 3 days intubation excluded. A descriptive analysis discharge status Day 180 was including stratification by age categories care level (CL) < or 3. The chi-square Fisher’s exact tests assess whether differed among CLs. Results In total, 272 study, median 78 (interquartile range: 73–84). duration 9.0 days. Pneumonia most frequent main diagnosis (12.5%). 73.5% achieved 42.6% discharged alive until day 180, while 19.9% hospitalized 37.5% deceased 180. did not differ However, requiring CL longer, significantly higher than that (35.1% vs 17.4%, p = 0.012). Conclusions This shows many can be successfully one third hospital fifth required prolonged hospitalization. hospitalization likely longer it may discuss only potential difficulty liberation, but also convey risks undesired outcomes physical function decline considering

Language: Английский

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Treatment Summary of Hospitalized Patients with Novel Coronavirus Infection in Neurology Department in Shaanxi Province DOI

雨晴史

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(11), P. 1357 - 1372

Published: Jan. 1, 2024

Language: Английский

Citations

A Retrospective Data Audit of Outcome of Moderate and Severe Covid-19 Patients Who Had Received MP and Dex: A Single Center Study DOI

Yupeng Li,

Chuanchuan Dong,

Y. Xing

et al.

Infection and Drug Resistance, Journal Year: 2024, Volume and Issue: Volume 17, P. 5491 - 5505

Published: Dec. 1, 2024

To evaluate the necessity of application glucocorticoid (GC) in moderate COVID-19 patients, and which is optimal choice between methylprednisolone (MP) dexamethasone (DEX) clinical use GC different types patients.

Language: Английский

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