Evaluation of Plasma Malondialdehyde among Sudanese Type 2 Diabetic Patients DOI Open Access

Gad Allah Modawe,

Ibtihal Elamin Mohammed,

Abuagla M. Dafalla

et al.

Open Journal of Endocrine and Metabolic Diseases, Journal Year: 2023, Volume and Issue: 13(12), P. 234 - 243

Published: Jan. 1, 2023

Background and objectives: Diabetes is a chronic multifactorial disease which requires variety of strategies to reduce its epidemic. Type 2 diabetes (T2MD) the most common form results from inefficiency insulin secretion or resistance action, both lead hyperglycemia. Lipid peroxidation an oxidative stress process that involve in T2DM complications. This study aimed 1) determine plasma malondialdehyde (MDA) levels as biomarker for lipid Sudanese patients with T2DM, 2) assess associations between MDA diabetes-related variables. Material Methods: case-control was conducted November 2022 June 2023 at National University, Sudan. It included 100 participants, whom 50 were healthy controls. Data on demographics, clinical characteristics, biochemical markers (FBS, HbA1c, MDA) collected. The NycoCard HbA1c method GOD-POD Method used glucose measurement, respectively. determined by thiobarbituric acid reactive substances method. data analyzed using SPSS Version. Results: Significant differences observed controls FBS (P = 0.000), 0.010), exhibiting higher levels. revealed strong positive correlation duration (r 0.69, P 0.00), while other variables, including age, BMI, control, did not significantly correlate Conclusion: Findings elevated patients, duration. These findings emphasize importance pathogenesis call need targeted mitigate damage improve care.

Language: Английский

Potential of Pterostilbene as an Antioxidant Therapy for Delaying Retinal Damage in Diabetic Retinopathy DOI Creative Commons
Raquel Burggraaf-Sánchez de las Matas, Isabel Torres-Cuevas, Iván Millán

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 244 - 244

Published: Feb. 20, 2025

Chronic hyperglycemia is a major driver of neurovascular damage in diabetic retinopathy (DR), leading cause preventable blindness adults. DR progression often undetected until its advanced stages, with oxidative stress recognized as primary contributor. In diabetes, disrupts retinal cellular balance, damaging proteins, DNA, and lipids, triggering photoreceptor degeneration. Pterostilbene (Pter), polyphenol antioxidant properties, has demonstrated protective effects animal models was assessed pilot clinical study. patients treated 250 mg/day oral Pter showed reduction the development vascular alterations characteristic disease. Urinary analyses confirmed Pter's role reducing lipid peroxidation polyunsaturated fatty acids (PUFAs), including arachidonic adrenic acids, indicators DR. also improved GSH/GSSG ratio, reflecting restored redox balance. However, after six months without treatment, reappeared, highlighting importance sustained intervention. These findings suggest that may help slow by protecting against highlight implementing therapies from diagnosis although long-term impact consistent biomarkers deserve more research to optimize management.

Language: Английский

Citations

0
Xanthones with multiple roles against diabetes: their synthesis, structure‐activity relationship, and mechanism studies DOI

Youhong Ke,

XU Qin-fang,

Jianling Hu

et al.

Drug Development Research, Journal Year: 2024, Volume and Issue: 85(2)

Published: March 13, 2024

Abstract A four‐step synthetic process has been developed to prepare 1,3,5,8‐tetrahydroxyxanthone ( 2a ) and its isomer 1,3,7,8‐tetrahydroxyxanthone 2b ). 25 more xanthones were also synthesized by a modified scheme. Xanthone was identified as the most active inhibitor against both α‐glucosidase aldose reductase (ALR2), with IC 50 values of 7.8 ± 0.5 μM 63.2 0.6 nM, respectively, which far than acarbose (35.0 0.1 μM), little epalrestat (67.0 3.0 nM). confirmed antioxidant in vitro EC value 8.9 μM. Any structural modification including methylation, deletion, position change hydroxyl group will cause an activity loss inhibitory antioxidation. By applying H 2 O ‐induced oxidative stress nematode model, it that xanthone can be absorbed Caenorhabditis elegans is bioavailable attenuate vivo stress, effects on lifespan, superoxide dismutase, Catalase, malondialdehyde. verified hypoglycemic effect mitigation embryo malformations high glucose. All our data support behaves triple roles potential agent treat diabetic mellitus, gestational diabetes complications.

Language: Английский

Citations

1
Inter-Relations between Dietary Patterns and Glycemic Control-Related Biomarkers on Risk of Retinopathy in Type 2 Diabetes DOI Open Access

Yu-Ju Wu,

Chih‐Cheng Hsu, Shang‐Jyh Hwang

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(14), P. 2274 - 2274

Published: July 15, 2024

Diabetic retinopathy (DR), which can cause vision loss, may progress faster with poor glycemic control and oxidative stress. This study aims to examine how dietary patterns biomarkers relate risk in type 2 diabetes patients. In this study, we enrolled diabetic patients (DR) (

Language: Английский

Citations

1
Hyperlipidemia and lipid-lowering therapy in diabetic retinopathy (DR): A bibliometric study and visualization analysis in 1993–2023 DOI Creative Commons

Haishan Tan,

Xiangyu Fu, Yongjiang Chen

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(10), P. e21109 - e21109

Published: Oct. 1, 2023

BackgroundDiabetic retinopathy (DR) is a common complication in diabetic patients. DR also neurodegenerative disease. Patients with hyperglycemia, hyperlipidemia, and hypertension are vulnerable to development. While the roles of blood glucose pressure development have been extensively studied, relationship between body fat pathogenesis impact lipid-reducing drugs on has just emerged as research hotspot study. We aim visualize contributions cooperation reporters, organizations, nations, addition hotspots trends DR-related lipid from 1993 2023, by bibliometric analysis.MethodsWe extracted all publications about 2023 Web Science Core Collection, features were studied using VOSviewer CiteSpace program.Results1402 documents retrieved. The number studies risen consistently for three decades, an average 16.8/year 1990s 28.8/year 2000s, 64.5/year 2010s, reached 112/year 2020–2022, confirming they hot topic field. These reports 93 nations/regions, USA, China, Japan, Australia, England taking leading positions. Diabetes Research Clinical Practice was journal that published most studies, Care quoted. identified 6979 authors, Wong TY having papers being commonly co-cited. popular keyword, according our research, retinopathy. Oxidative stress, macular edema (DME), peroxidation, other topics often investigated.ConclusionDR-related conducted mainly North America, Asia, Oceania, Europe. Much study centered lipid-lowering therapy pathogenesis. strongly support medications (fenofibrate, statins, omega-3 PUFAs), combined hyperglycemia therapy, prevent treat DR. However, fenofibrate or statin not correlated their action profiles. Thus, more randomized clinical trials primary endpoints related T1D T2D merited. In addition, biomarker (lipid aldehydes, ALEs, cholesterol crystals), medicines retinopathy, mechanism preventing curing DR, ocular delivery patients predicted focus future

Language: Английский

Citations

3
Investigating the effect of melatonin on serum changes of Adropin in patients with diabetic retinopathy, A randomized clinical trial DOI
Alireza Javadzadeh,

Peyman Ghodraty,

Zahra Saeedi-Maleki

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Abstract Background: This study aimed to determine the effect of oral melatonin on adropin serum levels in patients with diabetic retinopathy(DR) Methods and Design: randomized, single-blind clinical trial involved 22 DR who received additional treatment 3 mg/day for three months (group A) age-matched got only routine treatments B) A complete ophthalmic examination, including best corrected visual acuity (BCVA) (based LogMAR) slit lamp was done. grading based Early Treatment Diabetic Retinopathy Study (ETDRS) guidelines. adropin, MDA, hs-CRP were measured repeated after months. Descriptive statistics used describe demographic characteristics inferential (Mann Whitney U test, Spearman's rank correlation test) population, statistical significance level set at P < 0.05. Results: Significant differences between control groups (both before treatment) seen MDA (P = 0.005) Adropin 0.001), but there no significant biochemical parameter levels. Also, correlations changes Conclusions: In conclusion, our suggests that using alongside may increase decrease oxidative stress inflammatory process diabetes this reason we consider a therapeutic role treating retinopathy.

Language: Английский

Citations

0
Evaluation of Plasma Malondialdehyde among Sudanese Type 2 Diabetic Patients DOI Open Access

Gad Allah Modawe,

Ibtihal Elamin Mohammed,

Abuagla M. Dafalla

et al.

Open Journal of Endocrine and Metabolic Diseases, Journal Year: 2023, Volume and Issue: 13(12), P. 234 - 243

Published: Jan. 1, 2023

Background and objectives: Diabetes is a chronic multifactorial disease which requires variety of strategies to reduce its epidemic. Type 2 diabetes (T2MD) the most common form results from inefficiency insulin secretion or resistance action, both lead hyperglycemia. Lipid peroxidation an oxidative stress process that involve in T2DM complications. This study aimed 1) determine plasma malondialdehyde (MDA) levels as biomarker for lipid Sudanese patients with T2DM, 2) assess associations between MDA diabetes-related variables. Material Methods: case-control was conducted November 2022 June 2023 at National University, Sudan. It included 100 participants, whom 50 were healthy controls. Data on demographics, clinical characteristics, biochemical markers (FBS, HbA1c, MDA) collected. The NycoCard HbA1c method GOD-POD Method used glucose measurement, respectively. determined by thiobarbituric acid reactive substances method. data analyzed using SPSS Version. Results: Significant differences observed controls FBS (P = 0.000), 0.010), exhibiting higher levels. revealed strong positive correlation duration (r 0.69, P 0.00), while other variables, including age, BMI, control, did not significantly correlate Conclusion: Findings elevated patients, duration. These findings emphasize importance pathogenesis call need targeted mitigate damage improve care.

Language: Английский

Citations

1