Self-Reported adverse events among Chinese healthcare workers immunized with COVID-19 vaccines composed of inactivated SARS-CoV-2

Human Vaccines & Immunotherapeutics, Journal Year: 2022, Volume and Issue: 18(5)

Published: April 22, 2022

Mass vaccination is critical to control the pandemic of coronavirus disease 2019 (COVID-19). Fear adverse events (AEs) after COVID-19 a main factor associated with hesitancy. We aimed analyze AEs in healthcare workers (HCWs) vaccinated vaccines (Aikewei or CoronaVac) composed inactivated virus. used structured self-administered questionnaire conduct two surveys on among HCWs perinatal medicine and obstetrics/gynecology from April 5 21, 2021. In total, 1392 who had received at least one vaccine dose were included. Of them, 1264 (90.8%) females 1047 (75.2%) doses. The overall incidence any first second was 38.2% (532/1392) 31.0% (325/1047) respectively (χ2 = 13.506, P .0002). Female aged 18–30 y more likely report AEs. most common local reaction, accounting for 48.1% 67.4% all respectively. systemic mainly neurological (9.8% 4.8% injection respectively) flu-like symptoms (6.3% 3.2%). Overall, mild, only 5.1% (after dose) 2.8% individuals symptomatic treatment sick leaves, none them required hospitalization. Our data added evidence that are highly safe. valuable overcome hesitancy concerns about safety vaccines.

Language: Английский

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Reduced antibody response to COVID-19 vaccine composed of inactivated SARS-CoV-2 in diabetic individuals

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Dec. 8, 2022

Background Patients with type 2 diabetes mellitus (T2DM) are at increased risk for COVID-19 related morbidity and mortality. Antibody response to vaccine in T2DM patients is not very clear. The present work aims evaluate the antibody inactivated SARS-CoV-2 this population. Methods Two groups of subjects no history infection were included: 63 56 non-T2DM controls. Each participant received two doses vaccine. IgG antibodies against nucleocapsid (N) spike (S) proteins (anti-N/S IgG) receptor binding domain (RBD) (anti-RBD quantitatively evaluated by electrochemiluminescence immunoassays, respectively. Results It was observed that positive rates titers anti-N/S anti-RBD significantly lower than those controls, respectively (anti-N/S: 85.7 vs. 98.2%, P = 0.034; 25.48 33.58 AU/ml 0.011; anti-RBD: 96.4%, 0.044; 15.45 22.25 AU/ml, 0.019). Compared subjects, uncontrolled glycemia showed IgG: 75% 13.30 AU/ml; 11.91 respectively, all < 0.05), while controlled had similar 94.3% 33.65 19.82 > 0.05). Conclusion In analysis performed, data indicate a level compared non-diabetic controls individuals when immunized

Language: Английский

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COVID-19 vaccination coverage among adolescents aged 12–17 years in three provinces of eastern China: A cross-sectional survey, 2021

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: July 22, 2022

High vaccination coverage is essential to prevent and control the spread of COVID-19 epidemic. Currently, real-world acceptance vaccines among adolescents aged 12–17 years in China has not been reported. We aimed assess rate eastern identify factors associated with intention get vaccinated against COVID-19. conduct a cross-sectional questionnaire survey from three provinces part 16 August 28 October 2021. The questionnaires were distributed 2,100 students, 2,048 students completed questionnaires. results showed that 98.4% (2,016/2,048) had received at least one dose vaccine 1.6% (32/2,048) declined vaccination. participants rural districts, or whose parents vaccinated, more likely accept vaccine. main reason for declining was worry about safety (25%). adverse event after pain injection site. In conclusion, reached this study, which met criteria herd immunity severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). high beneficial prevention pandemic.

Language: Английский

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The effect of the Covid pandemic and lockdown on stillbirth rates in a South Indian perinatal centre

Journal of Perinatal Medicine, Journal Year: 2022, Volume and Issue: 50(6), P. 660 - 667

Published: June 16, 2022

The Covid-19 pandemic affected antenatal care in many parts of the world. It brought about changes as part control and containment measures. We examined effect first second waves India on stillbirth rates, indicators quality maternity care.Observational study at a tertiary referral perinatal centre with approximately 10,000 births annually. wave period was taken January to December 2020 lockdown March June 2020, which included complete shut down clinics ultrasound services. from September 2021. All women singleton pregnancy who had hospital based were included. investigated monthly trends obstetric load (new registrations, total clinic numbers births) continued (daily Covid case trend). compared overall well those that small for gestational age (<10th centile) delivery.There 9,251 32 stillbirths (rate 3.46/1,000) 6,228 14 (2.25/1,000). This represented 54% higher rate phase extended (p=0.08). incidence SGA significantly wave: vs. 2, (p=0.03).Reduced access planned during associated significant increase stillbirths.

Language: Английский

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