Genomic surveillance of SARS-CoV-2 and emergence of XBB.1.16 variant in Rajasthan

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 12, 2024

Abstract Background & objectives Genomic surveillance of positive SARS-CoV-2 samples is important to monitor the genetic changes occurring in virus, this was enhanced after WHO designation XBB.1.16 as a variant under monitoring March 2023. From 5 th February till 6 May 2023 all were monitored for changes. Methods A total 1757 having Ct value <25 (for E and ORF gene) from different districts Rajasthan processed Next Generation sequencing (NGS). The FASTA files obtained on used lineage determination using Nextclade phylogenetic tree construction. Results discussion Sequencing identification done 1624 samples. predominant 1413(87.0%) cases while rest other XBB (207, 12.74%) lineages (4, 0.2%). Of 1413 cases, 57.47% males 42.53% females. Majority (66.53%) belonged 19-59 year age. 84.15% infected first time. Hospitalization required only 2.2% death reported (0.35%) patients. Most symptomatic commonest symptoms fever, cough rhinorrhoea. Co-morbidities present 414 (29.3%) cases. Enhanced genomic helped rapidly identify spread Rajasthan. This turn take control measures prevent virus estimate public health risks new relative previously circulating lineages. found but produced milder disease.

Language: Английский

Genomic surveillance of SARS-CoV-2 and emergence of XBB.1.16 variant in Rajasthan

Indian Journal of Medical Microbiology, Journal Year: 2024, Volume and Issue: 50, P. 100659 - 100659

Published: July 1, 2024

Genomic surveillance of positive SARS-CoV-2 samples is important to monitor the genetic changes occurring in virus, this was enhanced after WHO designation XBB.1.16 as a variant under monitoring March 2023. From 5th February till May 6, 2023 all were monitored for changes. A total 1757 having Ct value <25 (for E and ORF gene) from different districts Rajasthan processed Next Generation Sequencing (NGS). The FASTA files obtained on sequencing used lineage determination using Nextclade phylogenetic tree construction. identification done 1624 samples. predominant 1413 (87.0%) cases while rest other XBB (207, 12.74%) lineages (4, 0.2%). Of cases, 57.47% males 42.53% females. Majority (66.53%) belonged 19–59 year age. 84.15% infected first time. Hospitalization required only 2.2% death reported 5 (0.35%) patients. Most symptomatic commonest symptoms fever, cough rhinorrhea. Co-morbidities present 414 (29.3%) cases. Enhanced genomic helped rapidly identify spread Rajasthan. This turn take control measures prevent virus estimate public health risks new relative previously circulating lineages. found but produced milder disease.

Language: Английский