Guideline for the Prevention and Treatment of Metabolic Dysfunction-associated Fatty Liver Disease (Version 2024)

Journal of Clinical and Translational Hepatology, Journal Year: 2024, Volume and Issue: 000(000), P. 000 - 000

Published: Nov. 4, 2024

With the rising epidemic of obesity, metabolic syndrome, and type 2 diabetes mellitus in China, dysfunction-associated non-alcoholic fatty liver disease has become most prevalent chronic disease. This condition frequently occurs Chinese patients with alcoholic hepatitis B. To address impending public health crisis its underlying issues, Society Hepatology Medical Association convened a panel clinical experts to revise update "Guideline prevention treatment (2018, China)". The new edition, titled for (Version 2024)", offers comprehensive recommendations on key including screening monitoring, diagnosis evaluation, treatment, follow-up steatotic Metabolic is now preferred English term used interchangeably Additionally, guideline emphasizes importance multidisciplinary collaboration among hepatologists other specialists manage cardiometabolic disorders effectively.

Language: Английский

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Assessment of ChatGPT-generated medical Arabic responses for patients with metabolic dysfunction–associated steatotic liver disease

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0317929 - e0317929

Published: Feb. 3, 2025

Background and aim Artificial intelligence (AI)-powered chatbots, such as Chat Generative Pretrained Transformer (ChatGPT), have shown promising results in healthcare settings. These tools can help patients obtain real-time responses to queries, ensuring immediate access relevant information. The study aimed explore the potential use of ChatGPT-generated medical Arabic for with metabolic dysfunction–associated steatotic liver disease (MASLD). Methods An English patient questionnaire on MASLD was translated Arabic. questions were then entered into ChatGPT 3.5 November 12, 2023. evaluated accuracy, completeness, comprehensibility by 10 Saudi experts who native speakers. Likert scales used evaluate: 1) Accuracy, 2) Completeness, 3) Comprehensibility. grouped 3 domains: (1) Specialist referral, (2) Lifestyle, (3) Physical activity. Results Accuracy mean score 4.9 ± 0.94 a 6-point scale corresponding “Nearly all correct.” Kendall’s coefficient concordance (KCC) ranged from 0.025 0.649, 0.28, indicating moderate agreement between experts. Mean completeness 2.4 0.53 3-point “Comprehensive” (KCC: 0.03–0.553; mean: 0.22). Comprehensibility 2.74 0.52 scale, which indicates “Easy understand” 0.00–0.447; 0.25). Conclusion found that accurate, complete, comprehensible. support increasing trend leveraging power AI chatbots revolutionize dissemination information MASLD. However, many AI-powered require further enhancement scientific content avoid risks circulating misinformation.

Language: Английский

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Post‐TIPS Overt Hepatic Encephalopathy Increases Long‐Term but Not Short‐Term Mortality in Cirrhotic Patients With Variceal Bleeding: A Large‐Scale, Multicenter Real‐World Study

Alimentary Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Transjugular intrahepatic portosystemic shunt (TIPS) is an established procedure for managing portal hypertension in cirrhotic patients, but the impact of post-TIPS overt hepatic encephalopathy (OHE) on survival remains controversial. While its effect short-term well-documented, long-term implications remain unclear. This study aims to investigate OHE mortality patients variceal bleeding, focusing timing and predictive value beyond first year post-TIPS. A multicenter, retrospective cohort was conducted involving 3262 who underwent TIPS bleeding at seven Chinese tertiary centers between January 2010 June 2020. Clinical data, including demographics, details, complications outcomes, were collected. The primary endpoints all-cause OHE, with follow-up until death, liver transplantation or 60 months. Propensity score matching minimised confounding effects, multivariate Fine-Grey competing risk models identified independent predictors. During a median 1077 days, 33.2% developed associated higher MELD Child-Pugh scores. Among these, 19.3% died, time from onset death 947 days. Post-TIPS not linked early (within 12 months) emerged as predictor 24 months, consistent across various clinical scenarios. does affect significantly increases risk. These findings highlight need continuous monitoring tailored interventions improve outcomes patients.

Language: Английский

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Effects of combined prebiotic fiber supplementation and weight loss counseling in adults with metabolic dysfunction-associated steatotic liver disease: a randomized controlled trial

European Journal of Nutrition, Journal Year: 2025, Volume and Issue: 64(4)

Published: April 2, 2025

Language: Английский

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Preventive behavioral interventions for patients with steatotic liver disease

Clinical Liver Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Jan. 1, 2024

Language: Английский

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Integrating behavioral interventions into a holistic approach to metabolic dysfunction-associated steatotic liver disease

Expert Review of Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 18(7), P. 303 - 313

Published: July 2, 2024

The therapeutic landscape of Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) is rapidly evolving with the FDA approval resmetirom, first authorized molecule to treat metabolic dysfunction-associated steatohepatitis. Clinical trials are investigating other promising molecules. However, this focus on pharmacotherapy may overshadow lifestyle interventions, which remain cornerstone MASLD management. A significant percentage patients struggle an underlying eating disorder, often a precursor obesity. obesity pandemic, exacerbated by increasing prevalence binge eating, underscores need for psychological approach address their common roots.

Language: Английский

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Editorial: Does knowledge about liver disease enhance adherence to lifestyle recommendations?

Alimentary Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 59(2), P. 283 - 284

Published: Dec. 28, 2023

LINKED CONTENT This article is linked to Petroni et al papers. To view these articles, visit https://doi.org/10.1111/apt.17768 and https://doi.org/10.1111/apt.17810

Language: Английский

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