Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 36(2), P. 110211 - 110211
Published: July 4, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Oct. 9, 2024
Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly influence the immune system, impacting both physiological and pathological processes. This review explores diverse functions nine mammalian IRF members, each featuring conserved domains essential for interactions with other factors cofactors. These allow IRFs to modulate broad spectrum processes, encompassing host defense, response, cell development. Conversely, their pivotal role in regulation implicates them pathophysiology various diseases, such as infectious autoimmune disorders, metabolic cancers. In this context, display dichotomous nature, functioning tumor suppressors promoters, contingent upon specific disease milieu. Post-translational modifications IRFs, including phosphorylation ubiquitination, play crucial modulating function, stability, activation. As prospective biomarkers therapeutic targets, present promising opportunities intervention. Further research is needed elucidate precise mechanisms governing regulation, potentially pioneering innovative strategies, particularly cancer treatment, where equilibrium activities paramount importance.
Language: Английский
Citations
15
BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 23, 2025
Oxidative stress is a crucial pathophysiological mechanism in chronic diseases and mortality. While individual oxidative markers have been studied, the comprehensive impact of balance on mortality risks remains unclear, particularly among cancer survivors. We aimed to investigate associations Balance Score (OBS) with both general population This study included 37,317 adults (52% female) from National Health Nutrition Examination Survey (2001-2018). OBS was calculated based antioxidant pro-oxidant exposures categorized into quartiles. Survey-weighted Cox proportional hazards models were used estimate hazard ratios for risks. Restricted cubic spline analyses performed examine potential non-linear relationships. Stratified conducted further refine findings. During mean follow-up 9.1 years, 5,092 deaths occurred. Compared lowest quartile, highest quartile total associated lower all-cause (HR 0.68) 0.55). Among survivors, similar observed 0.66). Component analysis revealed consistent protective effects 0.60 mortality), while higher showed varying across causes. Higher risks, cancer-related mortality, effects, varied by
Language: Английский
Citations
1
Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123133 - 123133
Published: Jan. 1, 2025
Language: Английский
Citations
1
BMC Pharmacology and Toxicology, Journal Year: 2025, Volume and Issue: 26(1)
Published: Feb. 17, 2025
Chronic obstructive pulmonary disease (COPD) pathogenesis is influenced by environmental factors, including Benzo(a)pyrene (BaP) exposure. This study aims to identify BaP-related toxicological targets and elucidate their roles in COPD development. A comprehensive bioinformatics approach was employed, the retrieval of from Comparative Toxicogenomics Database (CTD) Super-PRED database, identification differentially expressed genes (DEGs) GSE76925 dataset, protein-protein interaction (PPI) network analysis. Functional enrichment immune infiltration analyses were conducted using GO, KEGG, ssGSEA algorithms. Feature related BaP exposure identified SVM-RFE, Lasso, RF machine learning methods. nomogram constructed validated for risk prediction. Molecular docking performed evaluate binding affinity with proteins encoded feature genes. We 72 COPD. analysis highlighted pathways oxidative stress inflammation. Immune revealed significant increases B cells, DC, iDC, macrophages, T helper Tcm, TFH patients compared controls. Correlation showed strong links between stress, inflammation pathway scores, aDC, Th1 Th2 cells. Seven (ACE, APOE, CDK1, CTNNB1, GATA6, IRF1, SLC1A3) across based on these high diagnostic accuracy clinical utility. highest suggestive its pivotal role BaP-induced pathogenesis. The elucidates molecular mechanisms COPD, specifically highlighting promoting cell infiltration. may serve as potential biomarkers therapeutic targets. Additionally, demonstrates predicting risk, providing a valuable tool application BaP-exposed individuals.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6874 - 6874
Published: June 22, 2024
The interferon regulatory factors (IRFs) family comprises 11 members that are involved in various biological processes such as antiviral defense, cell proliferation regulation, differentiation, and apoptosis. Recent studies have highlighted the roles of IRF1-9 a range liver diseases, including hepatic ischemia-reperfusion injury (IRI), alcohol-induced injury, Con A-induced nonalcoholic fatty disease (NAFLD), cirrhosis, hepatocellular carcinoma (HCC). IRF1 is progression IRI through signaling pathways PIAS1/NFATc1/HDAC1/IRF1/p38 MAPK IRF1/JNK. regulation downstream IL-12, IL-15, p21, p38, HMGB1, JNK, Beclin1, β-catenin, caspase 3, 8, IFN-γ, IFN-β other genes IRI, development HCC PD-L1, IL-6, IL-8, CXCL1, CXCL10, CXCR3. In addition, IRF3-PPP2R1B IRF4-FSTL1-DIP2A/CD14 NAFLD. Other IRF also play moderately important functions different diseases. Therefore, given significance IRFs diseases lack comprehensive compilation their molecular mechanisms this review dedicated to exploring
Language: Английский
Citations
5
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: March 28, 2025
Sepsis is defined as a condition related to infection that manifests with multiorgan dysfunction, representing life-threatening state. Consequently, severe complications frequently occur, liver injury being one of the most prevalent serious sepsis. Liver dysfunction during sepsis serves an independent predictor mortality. This review provides comprehensive overview current research on sepsis-induced (SILI), encompassing clinical manifestations, diagnostic criteria, pathogenesis and therapeutic strategies associated this condition. SILI may manifest hypoxic hepatitis due ischemia shock, cholestasis resulting from abnormal bile metabolism, or duct sclerosis. The pathophysiology involves intricate interactions among inflammatory response, oxidative stress, cell death. All these factors complicate treatment represent potential targets for intervention. Furthermore, addresses limitations inherent in conventional therapies currently employed managing emphasizes novel targeted aimed at addressing fundamental mechanisms underlying
Language: Английский
Citations
0
British Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 181(12), P. 1695 - 1719
Published: March 25, 2024
Abstract Cardio‐cerebrovascular diseases encompass pathological changes in the heart, brain and vascular system, which pose a great threat to health well‐being worldwide. Moreover, metabolic contribute exacerbate impact of diseases. Inflammation is complex process that protects against noxious stimuli but also dysregulated numerous so‐called inflammatory diseases, one atherosclerosis. involves multiple organ systems cascade molecular cellular events. Numerous studies have shown inflammation plays vital role cardio‐cerebrovascular The absent melanoma 2 (AIM2) inflammasome detects subsequently activated by double‐stranded DNA damaged cells pathogens. With assistance mature effector molecule caspase‐1, AIM2 performs crucial biological functions underpin its involvement related diseases: production interleukin‐1 beta ( IL-1β ), interleukin‐18 IL-18 ) N‐terminal pore‐forming Gasdermin D fragment (GSDMD‐N) mediates series responses programmed cell death (pyroptosis PANoptosis). Currently, several agents been reported inhibit activity potential be evaluated for use clinical settings. In this review, we systemically elucidate assembly, functions, regulation mechanisms outline inhibitory as therapeutic drugs.
Language: Английский
Citations
3
Journal of Zhejiang University SCIENCE B, Journal Year: 2024, Volume and Issue: 25(6), P. 451 - 470
Published: June 1, 2024
Language: Английский
Citations
3
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 13, 2024
This paper explores the significant role of epigenetics in women's reproductive health, focusing on impact environmental factors. It highlights crucial link between epigenetic modifications-such as DNA methylation and histones post-translational modifications-and health issues, including infertility pregnancy complications. The reviews influence pollutants like PM2.5, heavy metals, endocrine disruptors gene expression through mechanisms, emphasizing need for understanding how dietary, lifestyle choices, exposure to chemicals affect health. Future research directions include deeper investigation into female leveraging editing mitigate changes improving IVF success rates managing disorders.
Language: Английский
Citations
3
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 337, P. 118925 - 118925
Published: Oct. 10, 2024
Language: Английский
Citations
2