The fibrosis-4 index and its association with carotid atherosclerosis in type 2 diabetes: a cross-sectional study in China

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 20, 2025

The medical community has long been concerned about the cardiovascular disease risk in patients with type 2 diabetes. While liver fibrosis scores were originally designed for application individuals steatosis, an increasing number of studies have shown that they are also associated risk. However, association between Fibrosis-4 (Fib-4) and carotid atherosclerosis (CA) diabetes remains unclear. aim this study is to investigate Fib-4 index CA Type Additionally, it seeks determine whether relationship influenced by factors including gender, age, body mass (BMI), hypertension, other variables. Screening based on inclusion exclusion criteria identified 2658 hospitalized Subsequently, divided into three groups according values (Fib-4 < 1.3, 1.3 ≤ 2.67, ≥ 2.67). Logistic regression analysis was then applied evaluate presence Further stratified analyses conducted considering age (using 60 years as threshold), hypertension status, smoking, alcohol consumption, BMI 24 kg/m2 aiming potential effect heterogeneity within predefined subgroups. ROC curve used predictive power value CA, increased CIMT, plaques. encompassed diagnosed diabetes, comprising 1441 males 1217 females, average 56.71 ± 10.22 years. Among them, 1736 (65.3%) exhibited 1243 (46.8%) had intima-media thickness (CIMT), 1273 (47.9%) manifested Following adjustments various factors, prevalence a progressive increase 2.67 groups, statistically significant differences (P 0.05). Moreover, CIMT plaques group remained significantly higher than after In group, subsequent drinking, surpassed Despite further multiple persisted yet difference lacked statistical significance > results indicated AUC predicting 0.602 0.001, 95% CI: 0.579–0.625), while 0.561 0.540–0.583) 0.580 0.558–0.601), respectively. Elevated levels 1.3) positively As such, may serve biomarker detection its clinical utility needs validation, particularly larger sample sizes multicenter studies.

Language: Английский

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Impact of steatotic liver disease subtypes, sarcopenia, and fibrosis on all-cause and cause-specific mortality: a 15.7-year cohort study

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 11, 2025

Steatotic liver disease (SLD) was a newly proposed category derived from metabolic dysfunction-associated fatty (MAFLD). MAFLD and sarcopenia were independent risk factors for mortality. We aimed to evaluate the impacts of SLD subtypes, MAFLD, on A total 6543 subjects identified National Health Nutrition Examination Survey 1999–2006 with latest Linked Mortality file. Hepatic steatosis, advanced fibrosis, determined by laboratory- anthropometry- based index fibrosis-4 index, dual-energy X-ray absorptiometry-based appendicular skeletal muscle mass respectively. Associations mortality estimated using weighted Cox proportional hazards model. During mean follow-up time 15.7 years, 1567 (16.7%) deaths occurred including 494 (4.9%) cardiovascular diseases 372 (4.1%) cancer. The all-cause rates steatotic (MASLD), dysfunction alcohol-associated (MetALD), other aetiology SLD, MASLD without sarcopenia, 21.0%, 19.8%, 30.2%, 30.9%, 19.2%, 75.5%, increased (hazard ratio [HR] 1.26, 95% confidence interval [CI] 1.00-1.59). predicted (HR 1.17, CI 1.03–1.33) but this prediction became insignificant after adjustment risks. In contrast, MetALD significantly associated 1.83, 1.21–2.76; HR 2.50, 1.82–3.44, respectively), predominantly cancer-specific 2.42, 1.23–4.74; 2.49, 1.05–5.90, respectively). almost twice 2.19, 1.37–3.49) further coexisting fibrosis additively 3.41, 1.92–6.05). definition more homogeneous group metabolically hepatic steatosis at higher risks or MASLD-related

Language: Английский

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Metabolic dysfunction‐associated steatotic liver disease is a risk factor for gallstones: A multicenter cohort study

Hepatology Research, Journal Year: 2025, Volume and Issue: 55(5), P. 663 - 674

Published: Feb. 9, 2025

Abstract Aim Gallstone formation is associated with metabolic dysfunction. Recently, new definitions of steatotic liver disease (SLD) have been proposed, including dysfunction‐associated SLD (MASLD) and moderate alcohol intake (MetALD). We investigated the effects MASLD/MetALD on gallstone formation. Methods This multicenter observational cohort study enrolled 8766 consecutive health‐check examinees who underwent abdominal ultrasonography between 2008 2021 (total observation period 39,105.9 person‐years). All patients were classified into non‐SLD, MASLD, or MetALD groups. The effect MASLD development was evaluated using multivariate Cox regression analysis. Results Age, male sex, identified as independent risk factors for development. a significantly higher developing gallstones than non‐SLD (hazard ratio [HR] 1.7112; 95% confidence interval [CI] 1.4294–2.0486; p < 0.0001) (HR 1.3516, CI 1.0130–1.8033, = 0.0406). However, did not differ Hypertension only significant cardiometabolic factor in group 1.4350, 1.0545–1.9528; 0.0216). Random forest analysis directed acyclic graphs hypertension most important direct affecting MASLD. Conclusions an development, whereas presented similar non‐SLD. Moderate consumption may reduce be

Language: Английский

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Adherence to the planetary health diet index and metabolic dysfunction-associated steatotic liver disease: a cross-sectional study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 20, 2025

Adherence to the Planetary Health Diet Index (PHDI) has been shown benefit both individual health and planet. However, its impact on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) remains unclear. This study aimed investigate relationship between PHDI adherence MASLD risk. We analyzed a cohort of 15,865 adults (aged ≥18 years) using data from National Nutrition Examination Survey (NHANES, 2005-2018). The was derived 24-h dietary assessments comprised scores 15 food groups. Multivariate logistic regression used association MASLD, while restricted cubic spline (RCS) threshold analysis were employed explore potential non-linear relationship. Subgroup analyses conducted assess influence various demographic clinical characteristics observed associations. Mediation performed evaluate indirect effect weighted quantile sum (WQS) nutrients MASLD. Among cohort, 6,125 individuals diagnosed with revealed that higher quintile significantly associated reduced risk in fully adjusted model (OR = 0.610, 95%CI 0.508-0.733, p < 0.001). Notably, nonlinear relationships through RCS (p 0.002). indicated particularly effective reducing among females, those education attainment, living partner. WQS identified saturated fatty acids as most significant factor contributing (weight 0.313). Additionally, BMI waist circumference (81.47 87.66%, respectively) partially mediated risk, suggesting operates, part, circumference. remained robust across multiple sensitivity analyses. Our findings indicate is linked lower providing crucial insights for strategies at mitigating epidemic simultaneously fostering environmental sustainability.

Language: Английский

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Steatotic Liver Disease Prevalence in China: A Population‐Based Study and Meta‐Analysis of 17.4 Million Individuals

Alimentary Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

ABSTRACT Background Steatotic liver disease (SLD), including metabolic dysfunction‐associated SLD (MASLD), has emerged as a leading cause of chronic in China. Aims We aimed to provide comprehensive and updated description prevalence Methods described the prevalence, subgroup distribution, clinical characteristics Taizhou Study Liver Diseases (T‐SOLID). Additionally, we searched for studies reporting five databases. Eligible data were analysed using generalised linear mixed model. Linear regression was applied estimate annual average percentage change (AAPC). Results Of 28,623 participants T‐SOLID, 30.8% diagnosed with SLD, among which 83.8% classified MASLD. Prevalence increased from 22.1% 2018 36.7% 2021. The meta‐analysis included 792 publications 17,404,296 subjects. Nationwide, pooled rose 23.8% (95% CI 21.9%–25.9%) during 2001–2010 27.9% (26.0%–29.8%) 2016–2023 general population (AAPC = 2.56, p < 0.0001), equating approximately 402.0 million cases. An increase observed subpopulations by region, sex, age, high‐risk groups. Northeast China had highest (35.0%). Males higher rate than females (35.0% vs. 20.6%). ranging 8.1% children adolescents 31.8% elderly. Meta‐regression identified calendar period, geographical area, residence area significant determinants prevalence. Conclusion ubiquitously rising Chinese populations underscores urgent need targeted public health interventions.

Language: Английский

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Unmet needs of metabolic dysfunction – Associated “fatty or steatotic” liver disease

Tzu Chi Medical Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Nonalcoholic fatty liver disease (NAFLD), first named in 1980, is currently the most common chronic disease, imposing significant health, social, and economic burdens. However, it defined as a diagnosis of exclusion, lacking clear underlying cause its diagnostic criteria. In 2020, metabolic dysfunction-associated (MAFLD) was proposed replacement for NAFLD, introducing additional criteria related to dysfunction. 2023, steatotic (MASLD) suggested replace aiming avoid stigmatizing term "fatty" incorporating cardiometabolic This divergence nomenclature between MAFLD MASLD presents challenges medical communication progress. review outlines pros cons both terminologies, based on current research evidence, hope fostering global consensus future.

Language: Английский

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Impact of Cardiometabolic Risk Factors on Hepatic Fibrosis and Clinical Outcomes in MASLD: A Population-based Multi-Cohort Study

JHEP Reports, Journal Year: 2025, Volume and Issue: unknown, P. 101388 - 101388

Published: March 1, 2025

Language: Английский

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From NAFLD to MASLD: transforming steatotic liver disease diagnosis and management

Metabolism and Target Organ Damage, Journal Year: 2025, Volume and Issue: 5(1)

Published: March 8, 2025

The transition from non-alcoholic fatty liver disease (NAFLD) to metabolic dysfunction-associated steatotic (MASLD) represents a significant evolution in the nomenclature of disease. This updated terminology emphasizes dysfunction as central criterion, offering greater precision and improved risk stratification. MASLD broadens scope classification by incorporating individuals with diverse profiles, including lean patients hepatic steatosis, aligns clinical practice multifactorial nature this condition. global adoption creates opportunities for standardization research settings, facilitating multicenter collaborations enhancing development diagnostic tools therapeutic strategies. However, new poses challenges, potential confusion during implementation, cultural linguistic barriers, integration MetALD, need educational initiatives targeting healthcare providers patients. Further efforts are required refine criteria, address implementation seamlessly incorporate into international coding systems. review evaluates key advantages ongoing challenges associated MASLD, providing comprehensive analysis its impact on practice, research, health

Language: Английский

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MetALD: New Perspectives on an Old Overlooked Disease

Liver International, Journal Year: 2025, Volume and Issue: 45(5)

Published: April 3, 2025

ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) and alcohol‐associated (ALD) are the major contributors to burden globally. The rise in these conditions is linked obesity, type 2 diabetes, metabolic syndrome increased alcohol consumption. MASLD ALD share risk factors, pathophysiology histological features but differ their thresholds for use, definition does not require presence of dysfunction. A recent multi‐society consensus overhauled nomenclature steatosis introduced term MetALD describe patients with dysfunction who drink more than those less ALD. This new terminology aims enhance understanding management poses challenges, such as need accurately measure consumption research clinical practice settings. Recent studies show that has significant implications patient management, it associated mortality risks severe outcomes compared alone. face progression, cancer cardiovascular disease. diagnosis involves adequate quantification use through standardised questionnaires and/or biomarkers well proper assessment stage progression using non‐invasive tools including serologic markers, imaging, elastography techniques genetic testing. Effective requires addressing both alcohol‐related factors improve outcomes. review intends provide a comprehensive overview MetALD, covering pathogenesis, potential diagnostic approaches, strategies emerging therapies.

Language: Английский

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Metabolic score for visceral fat is correlated with all-cause and cardiovascular mortality among individuals with non-alcoholic fatty liver disease

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 10, 2025

Metabolic score for visceral fat (METS-VF) as an effective marker of obesity has been correlated with non-alcoholic fatty liver disease (NAFLD). This study aims to explore the correlation between METS-VF and both all-cause mortality cardiovascular (CVD)-related among individuals NAFLD. A cohort 6,759 subjects diagnosed NAFLD was selected from NHANES during period 1999 2018. Within this cohort, prognostic utility predicting CVD-related assessed. There a total 1254 deaths (18.6%) 418 (6.2%) at median follow-up 9.3 years. Multivariate Cox regression analysis restricted cubic splines indicated that can exhibit positive non-linearly CVD (HR: 4.15, 95% CI: 2.31-7.44, p < 0.001) 5.27, 3.75-7.42, 0.001), identified inflection point 7.436. Subgroup analyses further revealed stronger without diabetes. Furthermore, areas under curve (AUC) 1-, 3-, 5-, 10-year survival rates were 0.756, 0.740, 0.747 0.746 mortality, 0.774, 0.751, 0.758 respectively, which performs better than other IR related index. Elevated independently contributes increased risk in Not applicable.

Language: Английский

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