International Immunopharmacology,
Journal Year:
2024,
Volume and Issue:
146, P. 113880 - 113880
Published: Dec. 21, 2024
Adipose
mesenchymal
stem
cells
(ADSCs)
exert
beneficial
effects
on
kidney
disease
through
a
paracrine
mechanism.
However,
the
specific
molecular
mechanisms
by
which
ADSCs
treat
renal
fibrosis
are
not
yet
fully
understood.
Therefore,
it
is
crucial
to
clarify
therapeutic
of
ADSC-derived
extracellular
vesicles
(ADSC-EVs)
progression
and
their
underlying
mechanisms.
We
investigated
ADSC-EVs
both
in
vivo
vitro.
Key
genes
signaling
pathways
were
identified
with
RNA
sequencing
analysis
HK-2
cells.
The
role
mechanism
FOXS1/Wnt/β-catenin
pathway
mediating
antifibrotic
also
verified.
In
vivo,
found
that
ADSC-EV
treatment
significantly
improves
unilateral
ureteral
obstruction
(UUO)-induced
mice
models.
And
vitro,
our
data
suggested
can
reduce
epithelial-mesenchymal
transition
(EMT)
inhibit
transforming
growth
factor-β1
(TGF-β1)-treated
results
showed
FOXS1
was
primary
gene
involved
fibrosis.
RT-qPCR
reversed
elevated
level
TGF-β1-treated
UUO-induced
Moreover,
Western
blot
confirmed
alleviate
EMT
inhibiting
expression
treated
TGF-β1.
Furthermore,
overexpression
could
promote
occurrence
knockdown
Finally,
may
these
via
FOXS1-mediated
activation
Wnt/β-catenin
pathway.
Taken
together,
we
have
reducing
Stem Cell Research & Therapy,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 31, 2025
Abstract
Recent
studies
have
shown
that
mechanical
properties
such
as
extracellular
matrix
stiffness,
fluid
flow,
weight
loading,
compression,
and
stretching
can
affect
cellular
functions.
Some
examples
of
cell
responses
to
could
be
the
migration
cancer
cells
from
rigid
soft
surfaces
or
differentiation
fibroblasts
into
myofibroblasts.
Cellular
changes
modify
insertion
proteins
in
(ECM),
causing
an
increase
tissue
stiffness
with
functional
consequences.
In
general,
physical
factors
any
kind
phenotype
culture
conditions
vivo
tissues.
Cells
sense
stimuli
by
applying
force
restructuring
their
shape
functions
response
resistance
stimuli.
Furthermore,
triggers
develop
a
“memory”
for
altering
plasticity
adaptation.
This
phenomenon
is
called
memory
(CMM),
singular
feature
mesenchymal
stem
(MSCs).
Controlled
targeting
CMM
may
resolve
scarcity
viable
needed
based
therapy
(CBT)
implement
concerning
research,
fibrosis,
senescence.
review
focusses
on
mesodermal
lineage,
MSCs,
chondrocytes,
role
potential
target
CBT.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Dec. 20, 2024
Mesenchymal
stem
cells
(MSCs),
recognized
for
their
self-renewal
and
multi-lineage
differentiation
capabilities,
have
garnered
considerable
wide
attention
since
discovery
in
bone
marrow.
Recent
studies
underscored
the
potential
of
MSCs
immune
regulation,
particularly
context
autoimmune
diseases,
which
arise
from
system
imbalances
necessitate
long-term
treatment.
Traditional
immunosuppressive
drugs,
while
effective,
can
lead
to
drug
tolerance
adverse
effects,
including
a
heightened
risk
infections
malignancies.
Consequently,
adjuvant
therapy
incorporating
has
emerged
as
promising
new
treatment
strategy,
leveraging
immunomodulatory
properties.
This
paper
reviews
mechanisms
application
highlighting
regulate
responses
reduce
inflammation.
The
are
primarily
mediated
through
direct
cell
contact
paracrine
activity
with
cells.
review
lays
groundwork
broader
clinical
future
underscores
significant
scientific
value
prospects.
Further
research
is
expected
enhance
efficacy
safety
MSCs-based
treatments
diseases.
Journal of Zhejiang University (Medical Sciences),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Inflammatory
senescence
is
a
process
of
cellular
dysfunction
associated
with
chronic
inflammation,
which
plays
significant
role
in
the
onset
and
progression
liver
diseases,and
research
on
its
mechanisms
becomes
hotspot
currently.
In
viral
hepatitis,
inflammatory
primarily
involve
oxidative
stress,
cell
apoptosis
necrosis,
as
well
gut
microbiota
dysbiosis.
non-alcoholic
fatty
disease,
are
more
complex,
involving
insulin
resistance,
fat
deposition,
lipid
metabolism
disorders,
dysbiosis,
NAD+
abnormalities.
tumors,
characterized
by
weakening
tumor
suppressive
mechanisms,
remodeling
microenvironment,
metabolic
reprogramming,
enhanced
immune
evasion.
Therapeutic
strategies
targeting
have
been
developing
recently,
antioxidant
therapy,
disorder
improvement,
immunotherapy
emerging
important
interventions
for
diseases.
This
review
focuses
secescence
diseases,
aiming
to
provide
novel
insights
prevention
treatment
Frontiers in Digital Health,
Journal Year:
2025,
Volume and Issue:
7
Published: March 4, 2025
Background
Acute
lung
injury
is
a
common
respiratory
emergency
that
seriously
affects
the
life,
health
and
quality
of
life
patients,
especially
after
global
COVID-19
pneumonia.
The
application
nanotechnology
in
acute
promising.
In
response
to
knowledge
explosion
resulting
from
rapid
publication
growth,
we
applied
bibliometric
analysis
explore
research
profile
thematic
trends
field.
Methods
Articles
reviews
related
2004
2023
were
searched.
Java-based
Citespace,
VOSviewer,
R
software-based
Bibiometrix
used
systematically
evaluate
publications
by
spatiotemporal
distribution,
author
subject
categories,
topic
references,
keywords.
Results
A
total
1,347
included.
number
papers
has
grown
exponentially
over
past
20
years.
China
was
most
productive
country
out
all
53
countries,
followed
United
States.
Chinese
Academy
Sciences
institution
with
76
papers.
PARTICLE
AND
FIBRE
TOXICOLOGY
journal.
top
five
high-frequency
keywords
inflammation,
oxidative
stress,
toxicity,
vitro
,
respiratory-distress-syndrome.
And
emerging
delivery,
covid-19,
extracellular
vesicles,
therapy,
sars-cov-2.
Drug
delivery
are
focus
current
research.
Two
areas
represented
development
trends:
novel
nanocarriers
higher
efficiency
lower
biotoxicity,
other
impact
nanomaterials
progression
injury.
Conclusion
field
been
period
last
three
Delivery,targeted
exosm
have
this
trends:novel
biotoxicity
such
as
exosomes
solid
lipid
nanoparticles,
