Global, regional, and national burden of liver cancer in adolescents and young adults from 1990 to 2021: an analysis of the global burden of disease study 2021 and forecast to 2040

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 10, 2025

Background The global burden of liver cancer among adolescents and young adults (AYAs) has often been underestimated, despite significant shifts in its etiology. This study analyzes the disease AYAs from 1990 to 2021 forecasts trends up 2040 using data Global Burden Disease Study 2021. Our goal is provide insights that can inform resource allocation policy planning. Methods Incidence, mortality, disability-adjusted life years (DALYs) were extracted estimated annual percentage changes calculated assess trends. Correlation between age-standardized rates sociodemographic index (SDI) was analyzed Spearman correlation, future predicted Bayesian age-period-cohort model. Findings Globally, there 24,348 new cases 19,270 deaths 2021, with decreases for incidence, DALYs East Asia bears highest burden, males experiencing significantly higher than females. increases age, peaking at 35–39 years. Higher SDI associated lower DALYs. While HBV remains leading cause, NASH fastest-growing contributor incidence mortality. Projections indicate a continued decline AYAs, though female are expected rise. Interpretation Despite gradual emerging as rising cause Regional gender disparities persist, highlighting need tailored prevention healthcare strategies alleviate AYA's globally.

Language: Английский

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Global, regional and country burden of high BMI-related liver cancer among individuals aged above 70: trends from 1990 to 2021 and projections to 2044

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 20, 2025

Background Liver cancer (LC) is a major global health concern, being the fourth leading cause of cancer-related mortality. Older adults are more susceptible, though mortality rates for those over 70 declining. However, disability from non-communicable diseases remains high. High body mass index (BMI) notable risk factor LC, with high BMI-related liver (HB-LC) concern. Methods This study utilized Global Burden Disease (GBD) 2021 dataset to assess impact HB-LC on individuals aged and older 1990 2021, forecasts extending 2044. burden across socio-demographic (SDI) regions was evaluated using age-standardized disability-adjusted life years (DALYs). Joinpoint regression age-period-cohort models were used analyze DALY trends demographic influences, decomposition analysis assessed effects population aging, growth, epidemiological shifts. Results Our findings revealed significant geographical disparities in mortality, East Asia, Southeast parts West Africa showing highest rates. DALYs increased by 2.49% annually, low SDI experiencing recent acceleration. Gender disparity persisted, males facing steeper rise burden. Age-related peaked 80–89 age groups, complex patterns regions. Epidemiological changes primarily drove regions, while growth Conclusion data underscores necessity region-specific public strategies demographic-focused interventions, enhancing surveillance targeting efforts mitigate increasing among adults.

Language: Английский

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Rising Incidence of Early-Onset Liver Cancer and Intrahepatic Bile Duct Cancer: Analysis of the National Childhood Cancer Registry Database

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1133 - 1133

Published: March 28, 2025

Background/Objectives: Early-onset cancer is an emerging global health concern, including in the United States. However, data on early-onset liver and intrahepatic bile duct remain limited. This study aims to fill this gap by analyzing trends States over past two decades. Methods: used National Childhood Cancer Registry examine temporal The analysis involved estimating age-adjusted incidence rates of cancer, stratified histological type, ethnicity, sex. Results: In 2021, rate was estimated at 0.53 per 100,000 population (95% Confidence Interval [CI]: 0.48-0.59). From 2001 showed a significant annual percent change (APC) 1.35% CI: 0.87-1.83%). When sex, females increased significantly (APC: 3.07%, 95% 2.26-3.87%) while remaining stable males. Among racial ethnic groups, non-Hispanic American Indian Alaska Native (AIAN) individuals had highest rate, recorded 2.67 0.95-5.85). By hepatic carcinoma increasing time 1.47%, 0.96-1.99%). contrast, for hepatoblastoma unspecified tumors remained between 2021. Conclusions: Our identified States, primarily driven cases carcinoma.

Language: Английский

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Reduction in Liver Cancer Risk by Quercetin via Modulation of Urate Levels: Insights from Drug-Target Mendelian Randomization

Genes, Journal Year: 2025, Volume and Issue: 16(4), P. 449 - 449

Published: April 13, 2025

Background: Quercetin, a dietary flavonoid and widely used supplement, has hepatoprotective properties. Given its urate-lowering effects epidemiological evidence linking elevated serum urate levels to liver cancer risk, we tested whether quercetin reduces risk via modulation of by bioinformatics methods. Methods: We employed drug-target Mendelian randomization using genome-wide association study summary statistics from public databases (e.g., MRC-IEU) assess genetic associations, integrated these findings with GEO datasets (such as GSE138709 GSE179443) immune infiltration analyses tools like xCell, TIMER. Results: Our identified ABCG2-mediated elevation causal factor for hepatocellular carcinoma (OR = 1.001, p < 0.01), cholangiocarcinoma 3.424, fibrosis 2.528, 0.01). Single-cell transcriptomics revealed ABCG2 expression in endothelial cells, while analysis showed significant associations between both cell macrophage infiltration. Survival further indicated that was not associated poor prognosis or carcinoma. Conclusions: Considering quercetin’s multifaceted interactions BCRP/ABCG2, our support potential use preventive supplement hepatic diseases rather than an adjunctive therapy established cancer.

Language: Английский

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Alcohol‐Attributable Cancer: Update From the Global Burden of Disease 2021 Study

Alimentary Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

ABSTRACT Background and Aims Alcohol is a major risk factor for cancer development. Our study aimed to provide the updated global, regional national burden of alcohol‐attributable cancer. Approach Results We analysed Global Burden Disease Study 2021 determine death age‐standardised rate (ASDR) from change these measures between 2000 (reflected as annual percent [APC]), classified by region, nation country's developmental status, which based on sociodemographic index (SDI). In 2021, there were 343,370 deaths globally cancer, was an increase 51%. Alcohol‐attributable accounted 3.5% all deaths. Among liver (27%) highest mortality alcohol, followed oesophageal (24%) colorectal (16%). From ASDR decreased (APC: −0.66%). Regionally, fastest‐growing observed in South Asia. Classified SDI, low 0.33%) low‐to‐middle SDI countries 1.58%) exhibited uptrend While other cancers decreased, early‐onset (15–49 years) lip oral cavity increased 0.40%). Conclusions although declined, total number continued rise. This trend accompanied variations across groups types, particularly gastrointestinal cancers. Urgent efforts are needed both at levels address

Language: Английский

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Persistent Health Inequalities in the Burden of Gastrointestinal Cancers Among the Elderly From 1990 to 2021: A Population-Based Study

Cancer Control, Journal Year: 2025, Volume and Issue: 32

Published: Feb. 1, 2025

Introduction Globally, aging populations highlight gastrointestinal cancers as a major public health concern. Our study aimed to quantify the trends and inequalities in burden of among elderly from 1990 2021. Methods Utilizing 2021 Global Burden Diseases (GBD) database, our secondary analysis targeted disability-adjusted life-years (DALYs) for (60+). DALYs are composite indicator loss, calculated sum years life lost due premature mortality lived with disability. The age-standardized rate (ASDR) was using direct standardization method. Trends were quantified by estimated annual percentage change ASDR. Slope index inequality (SII) concentration employed absolute relative inequalities. Results In 2021, colon rectum cancer (CRC) had highest global ASDR elderly, followed stomach (SC), esophageal (EC), pancreatic (PC), liver (LC), gallbladder biliary tract (GBTC). Between decreased globally, except PC. Health exhibited varied patterns: EC showed worsening lower SDI countries SII, while SC experienced shift higher SII. LC displayed an improving EC, SC, demonstrated transition towards countries. CRC, GBTC, PC maintained countries, SII reflected improvements inequality. Conclusion From substantial decline observed cancers, Persistent evolving need comprehensive, multi-level interventions reduce disparities achieve equitable outcomes all.

Language: Английский

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Camellia Japonica Radix modulates gut microbiota and 9(S)-HpODE-mediated ferroptosis to alleviate oxidative stress against MASLD

Phytomedicine, Journal Year: 2025, Volume and Issue: 143, P. 156806 - 156806

Published: May 6, 2025

Language: Английский

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Liver cancer in young adults: Validity of global data sets

Hepatology, Journal Year: 2024, Volume and Issue: 80(4), P. 766 - 769

Published: April 29, 2024

Department of Clinical Sciences and Community Health, University Milan, Italy Correspondence Carlo La Vecchia, "La Statale" Via Celoria 22, 20133 Italy. Email: [email protected]

Language: Английский

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Diagnostics and omics technologies for the detection and prediction of metabolic dysfunction-associated steatotic liver disease-related malignancies

Metabolism, Journal Year: 2024, Volume and Issue: 161, P. 156015 - 156015

Published: Aug. 30, 2024

The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) continues to rise, making it the leading etiology chronic diseases and a prime cause liver-related mortality. MASLD can progress into steatohepatitis (termed MASH), fibrosis, cirrhosis, ultimately cancer. is associated with increased risks hepatocellular carcinoma (HCC) also extrahepatic malignancies, which develop in both cirrhotic non-cirrhotic patients, emphasizing importance identifying patients at risk developing MASLD-associated malignancies. However, optimal screening, diagnostic, stratification strategies for cancer are still under debate. Individuals MASH-associated cirrhosis recommended undergo surveillance HCC (e.g. by ultrasound biomarkers) every six months. No specific screening approaches MASLD-related malignancies cases established date. rapidly omics technologies, including genetics, metabolomics, proteomics, show great potential discovering non-invasive markers fulfill this unmet need. This review provides an overview on incidence mortality current diagnosis MASLD, evolving role technologies discovery prediction HCC.

Language: Английский

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Early-onset pancreatic cancer and associated metabolic risk factors in the Middle East and North Africa: A 20-year analysis of the Global Burden of Disease Study

Indian Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: unknown

Published: June 29, 2024

Language: Английский

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