Integrating multi-omics techniques and in vitro experiments reveals that GLRX3 regulates the immune microenvironment and promotes hepatocellular carcinoma cell proliferation and invasion through iron metabolism pathways DOI Creative Commons
Yang Li, Yuan Chen, Yang Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 25, 2024

Hepatocellular carcinoma (HCC) is a common malignancy worldwide, and its development closely related to abnormalities in iron metabolism. This study aims systematically analyze changes metabolism the tumor microenvironment of HCC using single-cell sequencing technology, investigate potential mechanisms by which regulation affects survival liver cancer patients.

Language: Английский

Alcohol and Hepatocellular Carcinoma DOI
Nghiem B. Ha, Francis Y. Yao

Clinics in Liver Disease, Journal Year: 2024, Volume and Issue: 28(4), P. 633 - 646

Published: July 23, 2024

Language: Английский

Citations

5
Enhanced prediction of 5-year postoperative recurrence in hepatocellular carcinoma by incorporating LASSO regression and random forest models DOI

Bing-Bing Su,

Chunhui Zhu, Jun Cao

et al.

Surgical Endoscopy, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

Citations

0
Alcohol-Metabolizing Enzymes, Liver Diseases and Cancer DOI Creative Commons
Tao Liu,

Feiyu Zhang,

Yue Feng

et al.

Seminars in Liver Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Alcohol is generally believed to be metabolized in the liver by alcohol dehydrogenase (ADH), aldehyde (ALDH), and a much lesser extent cytochrome P450 2E1 (CYP2E1) other enzymes. Recent studies suggest that gut also play important roles promotion of metabolism. ADH, ALDH, CYP2E1 have several polymorphisms markedly impact These alcohol-metabolizing enzymes not only affect alcohol-associated disease (ALD), but may modulate pathogenesis diseases cancer absence consumption. In this review, we discuss metabolism ALD, metabolic dysfunction–associated steatotic disease, dysfunction alcohol–associated viral hepatitis, cancer. We how endogenous ethanol production, affects Directions for future research on are elaborated.

Language: Английский

Citations

0
An update on IL-22 therapies in alcohol-associated liver disease and beyond DOI

Lihong Fu,

Burhan Yokus, Bin Gao

et al.

American Journal Of Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Exploring the microRNA-mitochondrial nexus in hepatocellular carcinoma DOI
Ali Jawad Akki, Srinivas Nanduri,

Shankargouda Patil

et al.

Mitochondrion, Journal Year: 2025, Volume and Issue: 84, P. 102045 - 102045

Published: April 24, 2025

Language: Английский

Citations

0
Immune dynamics shaping pre-metastatic and metastatic niches in liver metastases: from molecular mechanisms to therapeutic strategies DOI Creative Commons
Chang Zhu,

J Liao,

Yiyang Liu

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 14, 2024

Liver metastases are commonly detected in the advanced stages of various malignant tumors, representing a significant clinical challenge. Throughout process liver formation, immune cells play pivotal role, particularly pre-metastatic and metastatic niches within liver. Immune establish extensive intricate interactions with tumor other components liver, collectively promoting sustaining growth metastases. Despite limited efficacy existing therapeutic modalities against some metastases, novel immune-based treatment approaches continuously being explored validated. Building on systematic elucidation immunosuppressive characteristics we potential immunotherapies applicable to patients from multiple dimensions.

Language: Английский

Citations

3
Role of immune cell interactions in alcohol-associated liver diseases DOI Creative Commons

Xianda Wang,

Juan Wang,

Haodong Peng

et al.

Liver Research, Journal Year: 2024, Volume and Issue: 8(2), P. 72 - 82

Published: June 1, 2024

Research on inflammatory response, liver injury, and immune regulation has demonstrated that the intricate interactions among cells constitute a critical regulatory network. Alcohol consumption alters microenvironment, triggering inflammation responses. Elucidating inhibitory, cooperative, synergistic effects lymphocytes myeloid may reveal core mechanisms of alcohol-associated disease (ALD) pathogenesis identify promising therapeutic targets. This review seeks to elucidate multifaceted cells, encompassing both direct cellular secretion various effector molecules. It is essential underscore these have broader more complex roles in ALD than activities individual cell types. These play crucial role mutually regulating one another, thereby preserving homeostasis response environment. Targeting anticipated offer novel approach prevention treatment ALD.

Language: Английский

Citations

2
MCM4 potentiates evasion of hepatocellular carcinoma from sorafenib-induced ferroptosis through Nrf2 signaling pathway DOI

Xujin Liu,

Fan Zhang, Yu‐Chen Fan

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113107 - 113107

Published: Sept. 13, 2024

Language: Английский

Citations

2
Ethyl Lactate Ameliorates Hepatic Steatosis and Acute‐on‐Chronic Liver Injury in Alcohol‐Associated Liver Disease by Inducing Fibroblast Growth Factor 21 DOI Creative Commons
Yang Jiang, Shuang Wei,

Shiming Shen

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Aberrant upregulation of hepatic lipogenesis induced by chronic and excessive alcohol consumption is a critical driver the progression alcohol-associated liver disease (ALD), however, no effective approaches inhibiting are currently available for treating ALD patients. Moreover, little known about whether how nonethanol ingredients in alcoholic beverages regulate pathogenesis ALD. Here discovery small molecule that activates production secretion fibroblast growth factor 21 (FGF21) reported. It shown activator ethyl lactate, ingredient found distilled liquors, ameliorates hepatosteatosis, inflammation acute-on-chronic injury stimulating FGF21. In response to chronic-plus-binge ethanol feeding or fasting, lactate mimics lowering effects FGF21 through NAD

Language: Английский

Citations

2
KAISO Promotes Poor Prognosis in Hepatocellular Carcinoma Patients by Enhancing Neutrophil Infiltration via IGFBP1 DOI

Zhou Jiang,

Yiqiang Pang,

Haojun Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Abstract Background KAISO is a transcriptional regulator involved in gene expression, cell proliferation, and apoptosis, linked to cancer prognosis tumor aggressiveness, making it potential bi-omarker therapeutic target. Methods: We used bioinformatics analyses evaluate expression its effect on survival across 33 types of pan-cancer. also examined the link between immune infiltration. To investigate control down-stream proteins by KAISO, we dual-luciferase reporter assays, electrophoretic mobility shift assays (EMSA), chromatin immunoprecipitation (ChIP). Additionally, validated role regulating infiltration using subcutaneous model animals human samples. Results: Our research revealed that crucial growth progression various malignancies, including hepatocellular carcinoma (HCC). demonstrated high associated with poor HCC. was found regulate transcription IGFBP1 neutrophil influence HCC pro-liferation through cycle-related molecular pathways. Finally, confirmed reducing can inhibit growth. Conclusion: findings suggest could be an important biomarker target for patients.

Language: Английский

Citations

0