Integrating multi-omics techniques and in vitro experiments reveals that GLRX3 regulates the immune microenvironment and promotes hepatocellular carcinoma cell proliferation and invasion through iron metabolism pathways DOI Creative Commons
Yang Li, Yuan Chen, Yang Zhang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 25, 2024

Hepatocellular carcinoma (HCC) is a common malignancy worldwide, and its development closely related to abnormalities in iron metabolism. This study aims systematically analyze changes metabolism the tumor microenvironment of HCC using single-cell sequencing technology, investigate potential mechanisms by which regulation affects survival liver cancer patients.

Language: Английский

Alcohol and Hepatocellular Carcinoma DOI
Nghiem B. Ha, Francis Y. Yao

Clinics in Liver Disease, Journal Year: 2024, Volume and Issue: 28(4), P. 633 - 646

Published: July 23, 2024

Language: Английский

Citations

5
MCM4 potentiates evasion of hepatocellular carcinoma from sorafenib-induced ferroptosis through Nrf2 signaling pathway DOI

Xujin Liu,

Fan Zhang, Yu‐Chen Fan

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113107 - 113107

Published: Sept. 13, 2024

Language: Английский

Citations

4
Immune dynamics shaping pre-metastatic and metastatic niches in liver metastases: from molecular mechanisms to therapeutic strategies DOI Creative Commons
Chang Zhu,

J Liao,

Yiyang Liu

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 14, 2024

Liver metastases are commonly detected in the advanced stages of various malignant tumors, representing a significant clinical challenge. Throughout process liver formation, immune cells play pivotal role, particularly pre-metastatic and metastatic niches within liver. Immune establish extensive intricate interactions with tumor other components liver, collectively promoting sustaining growth metastases. Despite limited efficacy existing therapeutic modalities against some metastases, novel immune-based treatment approaches continuously being explored validated. Building on systematic elucidation immunosuppressive characteristics we potential immunotherapies applicable to patients from multiple dimensions.

Language: Английский

Citations

4
Enhanced prediction of 5-year postoperative recurrence in hepatocellular carcinoma by incorporating LASSO regression and random forest models DOI

Bing-Bing Su,

Chunhui Zhu, Jun Cao

et al.

Surgical Endoscopy, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

Citations

0
Alcohol-Metabolizing Enzymes, Liver Diseases and Cancer DOI Creative Commons
Tao Liu,

Feiyu Zhang,

Yue Feng

et al.

Seminars in Liver Disease, Journal Year: 2025, Volume and Issue: unknown

Published: March 29, 2025

Alcohol is generally believed to be metabolized in the liver by alcohol dehydrogenase (ADH), aldehyde (ALDH), and a much lesser extent cytochrome P450 2E1 (CYP2E1) other enzymes. Recent studies suggest that gut also play important roles promotion of metabolism. ADH, ALDH, CYP2E1 have several polymorphisms markedly impact These alcohol-metabolizing enzymes not only affect alcohol-associated disease (ALD), but may modulate pathogenesis diseases cancer absence consumption. In this review, we discuss metabolism ALD, metabolic dysfunction–associated steatotic disease, dysfunction alcohol–associated viral hepatitis, cancer. We how endogenous ethanol production, affects Directions for future research on are elaborated.

Language: Английский

Citations

0
An update on IL-22 therapies in alcohol-associated liver disease and beyond DOI

Lihong Fu,

Burhan Yokus,

Bin Gao

et al.

American Journal Of Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Exploring the microRNA-mitochondrial nexus in hepatocellular carcinoma DOI
Ali Jawad Akki, Srinivas Nanduri,

Shankargouda Patil

et al.

Mitochondrion, Journal Year: 2025, Volume and Issue: 84, P. 102045 - 102045

Published: April 24, 2025

Language: Английский

Citations

0
Liver resection versus interventional treatments for hepatocellular carcinoma patients with hypohepatia: a multicenter study DOI Creative Commons
Shoujie Zhao, Yejing Zhu,

Jinming Zhu

et al.

Surgical Endoscopy, Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Hypohepatia limits the feasibility of therapeutic options for hepatocellular carcinoma (HCC), negatively affecting patient prognosis. Established guidelines treatment strategies HCC patients with hypohepatia are lacking. This study was performed to evaluate benefits between liver resection (LR) and interventional treatments using ablation or transarterial chemoembolization (TACE) in such population. Survival analyses were Kaplan-Meier method log-rank test. The Cox proportional hazards regression models used analyze potential risk factors associated Multivariate propensity score adjustment applied adjust baseline confounding variables. Restricted cubic spline curves assess association prognostic index death progression on a continuous scale. Of enrolled 5774 hypohepatia, 506 (8.8%), 2326 (40.3%) 2942 (51.0%) underwent ablation, LR TACE, respectively. A tentative analysis overall cohort demonstrated that high degree heterogeneity existed this population, while rendered possible tendency survival benefit over TACE through After categorizing according indication treatment, indisputable superiority terms OS DFS before after adjustments evident advantages consistent across all pre-specified subgroups. Individualized decision based restricted group presented lowest disease progression. could obtain surgical non-surgical approaches. appears confer significant compared even selected intermediate advanced populations.

Language: Английский

Citations

0
Alcohol consumption and esophageal cancer risk: unveiling DLEU2 as a key immune modulator through Mendelian randomization and transcriptomic analysis DOI Creative Commons

Kailin Qu,

Jingyan Gu,

Zhi Xu

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 18, 2025

Esophageal cancer (EC) is a leading cause of cancer-related mortality globally, with alcohol consumption being significant risk factor. However, the genetic and molecular mechanisms linking intake to EC remain unclear. This study utilized Mendelian randomization analysis establish causal relationship between (OR: 4.11 [95% CI 1.83-9.23]). Transcriptomic identified 83 differentially expressed genes (log₂ fold change > 1, false discovery rate [FDR] < 0.05), among which DLEU2 was uniquely transcribed into long non-coding RNA (lncRNA). Pan-cancer revealed its association tumor immune microenvironment progression. Single-cell sequencing localized expression predominantly T cells, particularly exhausted subpopulations, pseudo-temporal demonstrated increased during late cell differentiation stages, co-expressing suppression markers, consistent patterns observed across multiple patient-derived samples. Additionally, communication suggested that modulates TNF signaling through TNFRSF1A/B pathways, contributing evasion poor prognosis. These findings position as pivotal regulator landscape in potential prognostic biomarker therapeutic target.

Language: Английский

Citations

0
Role of immune cell interactions in alcohol-associated liver diseases DOI Creative Commons

Xianda Wang,

Juan Wang,

Haodong Peng

et al.

Liver Research, Journal Year: 2024, Volume and Issue: 8(2), P. 72 - 82

Published: June 1, 2024

Research on inflammatory response, liver injury, and immune regulation has demonstrated that the intricate interactions among cells constitute a critical regulatory network. Alcohol consumption alters microenvironment, triggering inflammation responses. Elucidating inhibitory, cooperative, synergistic effects lymphocytes myeloid may reveal core mechanisms of alcohol-associated disease (ALD) pathogenesis identify promising therapeutic targets. This review seeks to elucidate multifaceted cells, encompassing both direct cellular secretion various effector molecules. It is essential underscore these have broader more complex roles in ALD than activities individual cell types. These play crucial role mutually regulating one another, thereby preserving homeostasis response environment. Targeting anticipated offer novel approach prevention treatment ALD.

Language: Английский

Citations

2